💸 Stem cell culture that’s ~95% cheaper and weekend-free: a win-win for PIs and trainees! Our revised manuscript is online at ORE: open-research-europe.ec.europa.eu/articles/4-1... Benchmarked across cell lines & differentiation protocols, including scRNA-seq — with lessons for #cultivatedmeat too!

Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.

CDS? ORF? Here is a new nomenclature for the translated regions of mRNAs: TRANSLON. www.nature.com/articles/s41...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

🚀 New from Cell: SPIDR is a game-changer—map dozens to hundreds of RNA-binding proteins simultaneously with single-nucleotide precision in one CLIP experiment. An exciting advance for RNA–protein interactomics! 🧬🔗https://doi.org/10.1016/j.cell.2025.06.042

I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004

Our recent article on transposable elements and aging - which made the June cover - is the focus of a new Highlight. "Highlight: 'Jumping Genes' Caught in an Aging Merry-Go-Round" 🔗 doi.org/10.1093/gbe/evaf094 🖌️ Miriam Merenciano #genome #TEsky

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

Our work on lineage tracing with somatic epimutations is finally out in @nature.com! Check out the thread by @larsplus.bsky.social below. EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere. Detailed protocols coming out soon!

New @nature.com An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer www.nature.com/articles/s41...

Congrats @micrornax.bsky.social on this study on let7 in lung injury/repair and thanks for including us as collaborators!

(4/n) Probing further with epigenomic experiments we demonstrated that Let-7 controls histone acetylation and methylation of H3K27 to reprogram the formation of profibrotic AT2 stem cells.

(3/n) We showed that Let-7 directly controls the expression of an extensive gene regulatory network comprised of transcription factors associated with fibrosis and cancer such as BACH1, EZH2, and MYC to safeguard the lung from scarring.

(2/n) We found that Let-7 serves as a molecular guardian of AT2 cells and prevents their abnormal growth and “transformation” into fibrotic scar forming KRT8+ transitional cells in pulmonary fibrosis.

(1/n) Our article is out in @natcomms.bsky.social! We set out to examine the contribution of the ancient Let-7 microRNA over alveolar type 2 (AT2) stem cell plasticity in the genesis of pulmonary injury and interstitial lung disease i work led by Matthew and Shafiq in my lab. Paper: rdcu.be/elun3

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks. https://go.nature.com/4kd1vIu

Look up the impact of NIH funding in your state: www.unitedformedicalresearch.org/nih-in-your-...

Can’t wait for RNA2025! Chairing a new Education session… more details soon!

An early holiday present from the @MorriseyLab! A story of stem cell collision/competition driving lung regeneration. A tour de force by Dakota…#WhyWeScience! www.science.org/doi/10.1126/...

Our annual Dance Your Ph.D. contest is open for submissions until March 28 💃 The entry form is here (plus more details in the article linked below): www.science.org/content/page...

I'm really excited to see Prisca's work highlighted here @yegracechen.bsky.social!

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

🚨 Update for #RNA science fans: I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far: 1. General RNA biology #1 go.bsky.app/RN6HnZp