On Sundays our busy Stroke Service stands ready to take on new challenges . . .

999 med students just matched to a #neurology residency program, the largest # of new neurologists ever! But: New cases every yr in the US: 90k -Parkinson 200k -epilepsy 800k -stroke 900k -Alzheimer Total living in the US: 1M -MS 1.1M -Parkinson 3.5M -active epilepsy 10M -dementia 45M -migraine

Here’s a great recap of #ISC26 International Stroke Conf from @befast.bsky.social. My meeting highlight: random march alongside the STORYVILLE STOMPERS and their leader! Also grateful for chance encounters with new and old friends - thanks for lighting up ideas for stroke science and practice.

My @bmj.com article about my stroke recovery and the importance of communication by health care professionals, especially around time frames: www.bmj.com/content/391/...

Nice work by @tomohikotakei.bsky.social expands understanding of the corticospinal pathway in primate fine motor control.

Our paper is out in Science Advances! What makes primate hands so dexterous? We show that evolutionarily distinct spinal and cortical pathways work together to balance stability and flexibility, supporting remarkable primate hand control. www.science.org/doi/10.1126/...

New free resource for physicians! Post-stroke spasticity is frequently missed but early identification makes all the difference. AAPM&R’s new microlearning series helps physicians who don’t treat spasticity learn more on the topic! Start learning today: ow.ly/K0fz50Y9lmc

Wow

Disappointing news for treatment of central retinal artery occlusion (CRAO, “stroke of the eye”). A new randomized trial shows no benefit of IV tenecteplase vs aspirin when given within 4.5 hours of onset. Fewer than 25% of patients in either group recovered vision. www.nejm.org/doi/10.1056/...

Pleased to share our new publication in STROKE: @americanheart.bsky.social Scientific Statement on Early Recognition and Intervention for Poststroke Spasticity. We support advances in research, training and implementation toward earlier diagnosis and timely, innovative spasticity treatments.

Finally found something Copilot can do:

Yesterday an interview was posted with Mike Lauer about the state of science. I strongly disagree with it. I will write more later. But for now: I agree w/ Lauer’s central points about budgets and paperwork and institutional incentives. But he seems to not realize the political minefield he is in.

“The system of funding science is fundamentally broken. In some respects, it’s been an unmitigated disaster. It was a house of cards, and it’s not surprising that it’s now falling apart.” -Mike Lauer, former director of extramural research 🧪 www.statecraft.pub/p/whats-wron...

Don’t miss the 2025 Stroke Review from bluesky’s vascular neurologist, Dr. Dymm, @befast.bsky.social!

Movie you’ve watched more than six times in a gif. Hard mode: no Star Wars, Marvel.

Important change: no pre-approval required for NIH proposals > $500K.

Ancillary studies are open. We’re working hard to get these samples into your hands. Please apply. recovercovid.org/ancillary

Did Apple Watch VO₂ max suddenly get way more flattering? Maybe something in the iOS 26 update? No explanation from Apple — but I’m not complaining.

Fellow scientists, enjoy this low-calorie treat from Nature Scientific Reports, topped with the very best #AI. Thanks @erikangner.com for brightening my holiday.

Thrilled to be at #sfn25 with some of the best #NeurorepairLab science ever! First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains. Sunday afternoon (today, board NN12). Cajal would be proud! eppro02.ativ.me/appinfo.php?...

#NIH proposals due soon? Have you seen this? All upcoming deadlines will be extended. (Mine was … tomorrow.) grants.nih.gov/grants/guide...

Am I the only one who sees a field of myelinated axons?

Incredible story of genius, art, and neuroscience.

New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com! Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on?? jamanetwork.com/journals/jam...

Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia. Despite heavy symptoms, most showed normal results. Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon. www.sciencedirect.com/science/arti...

US stroke neurologist here. Who can explain the new AI tool that tripled good outcomes and reduced treatment times by one hour, according to this article? From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?

That’s what happened to Google search? Proof that one person really can change the world!

Greatly appreciate this review of epigenetic mechanisms underlying regeneration competency only in young animals. Especially timely perspective for those of us puzzling over CNS repair.

Happy Birthday, new Parkland Hospital! Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*! While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care. www.parklandhealth.org/news-and-upd...

As owner of the stroke service “black cloud” it’s good to see the ED is well prepared for our kind of day.

Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary

Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells)whereas those for stroke relate to vascular integrity @cp-neuron.bsky.social www.cell.com/neuron/abstr...

Post-stroke fatigue can be long-lasting and disabling in patients recovering from a #stroke. New research identified a machine learning-based model that effectively predicted early post-stroke fatigue. Knowing who is at greatest risk can inform treatment. 🧪 🧠🔄 🧠📈 journals.sagepub.com/doi/abs/10.1...

Spectacular view from the 2025 Gordon Research Conference on CNS Injury & Repair near Barga, Italy. Terrific science happening here. Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution www.nature.com/articles/s41...

Thanks for posting this terrific paper from @erichorvitz.bsky.social and team! Neurologists will be on board as we traditionally embrace *sequential diagnosis* where each finding generates a new differential, leading hopefully to the best next steps. 1/2 Preprint: arxiv.org/abs/2506.22405

Calling all researchers! Learn the basics of reviewing a paper, structuring feedback, and some lesser-known benefits of reviewing in this upcoming webinar. Register and submit your questions today: vist.ly/3n8a4dx

Tenecteplace (TNK) is now FDA approved for acute stroke treatment! Brought to you by the letter “k”, here’s a great thread from bsky #stroke expert @befast.bsky.social.

It's official. For acute stroke treatment, Alteplase (tPA) is out, and Tenecteplase (TNK) is in. But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵

BOOM! I think this paper fills a big gap in understanding how motor cortex stim works for pain... like so many things, it all seems to boil down to the ventral-lateral periaqueductal grey (vlPAG) www.cell.com/neuron/fullt...

A new precision genetic toolkit allows scientists to access and study nearly 1,000 cells in the brain and spinal cord with unprecedented accuracy. Two of the lead scientists share on the NIH BRAIN Blog how it was made and impacts how we study disease: braininitiative.nih.gov/news-events/... 🧠📈

Appreciate this up to date review. Zebrafish and neonatal mice can do it!

Congratulation to the Lone Star Stroke Consortium, ready to begin our 13th year with research that improves clinical care and implementation for stroke patients across Texas! Grateful to our research sites and the Texas Legislature for the continuing vote of confidence. @lonestarstroke.bsky.social

Found in obscure basement hall of our public hospital. Whatever it is, I’m not authorized. Stealing for my email signature: Director, MIIC.

Colchicine to prevent arterial disease is fascinating. Clear evidence of benefit to prevent vascular events with no hint of mortality benefit (cardiovascular or not). academic.oup.com/eurheartj/ad...

These boxes are not moving. A mind-bending optical illusion by Japanese artist Jagarikin.

When the conference organizers ask if you can send in your slides a week in advance

Stroke hospital service, day 7. Another busy call night. As I head alone toward ICU to see the morning’s admissions, the team’s brand new NP threatens to call a SILVER ALERT! Fired! Or she should be - except for being outstanding in every other way.

Terrific thread on the human red nucleus from @samkrimmelneuro.bsky.social! New functional connectivity insights can help better understand how the (otherwise neglected) RN interacts in motor function after #stroke.