Excited to share our first lab preprint! We enabled fast wide-field FLIM with low noise and high dynamic range. We built compact resonant modules for EO-FLIM that fit into your hand and developed methods to capture multi-exponential phasor plots at up to 500 Hz. www.biorxiv.org/content/10.6...

Great few days at @mblscience.bsky.social supporting Neurobiology and NSB courses. It’s always exciting to see how ultrafast laser technology help enable new #neuroscience imaging methods. A big thank you to organizers, instructors, students, Coherent and others for making this event spectacular.

I’m going to spend a couple of days this week at @mblscience.bsky.social. Cool place, cool people and great science.

If you're not replacing your PMTs every 6 months, you might as well opt for SiPMs. src: www.nature.com/articles/s41... sipm: opg.optica.org/oe/fulltext.... www.nature.com/articles/s41...

With #FENS2026 just around the corner, our unofficial @fens.org abstract explorer is back: fens2026.neuronaldynamics.eu • Search abstracts by author, keyword, affiliation, and more • Discover related work using abstract similarity • Save favorites, add notes and tags, and build your own itinerary

Heading to Barcelona for my very first FENS! 🧠✨ Excited for the symposia, nerding out at posters, and presenting mine (PS07-10AM-005, Advanced Two-Photon Imaging Techniques, come say hi!). Also accepting applications for churros con chocolate buddies :) #FENS2026

Here’s our latest preprint on uncovering neural control of a coordinated walking pattern! doi.org/10.64898/202... (author-list jumbled, see pdf for corrected). Video shows the central paradigm in this study, we optogenetically induce walking in headless flies and sequentially reduce proprioception.

Back from #OpticaBiophotonics26. I had an opportunity to share how we think about lasers and our laser solutions for emerging imaging applications.

Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution #mini2p #Axon920 #laser www.biorxiv.org/content/10.6...

PinkyCaMP is finally published!! My first paper co-first authored with @sikmys.bsky.social where we make a great optogenetic and multiplex compatible red calcium indicator. Thank you to @massecklab.bsky.social and @campbell-lab.bsky.social for guiding this journey www.nature.com/articles/s41...

Open-source modular FPGA system for two-photon mesoscope: multiarea, multidepth neural activity recording. @riichirohira.bsky.social et al. present high throughput 2p calcium and what is maybe the largest field-of-view 2p fluorescence lifetime imaging (FLIM) data. doi.org/10.1117/1.NP...

I spent a bit more time thinking about this pre-print biorxiv.org/content/10.6... 👉3P isn't about more laser power. It's about the right rep rate, one pulse per pixel, and laser stability. If you are not measuring pulse-to-pulse noise you're not measuring your biology.

Practical optimization for three-photon microscopy to allow larger field of view and faster calcium imaging (10-30 Hz) www.biorxiv.org/content/10.6...

Easter time with my husband while our daughter is studying in PA

Back from #FOM2026. In multiphoton microscopy space label-free imaging, and spectroscopy in structural and metabolism biological imaging stood out. I’m excited to grow and support this space too.

*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️

The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...

We are finally online 🥳 What a fantastic adventure with @rrsims, the @emilianilab.bsky.social and all co-authors from IdV Paris #TwoPhoton #Voltagers #Holography #Rhodopsins

😎I'm delighted to announce that Coherent Corp. will be exhibiting at Sunposium Conference (mpfi.org/events/sunpo...) on Mar 09 - 11, 2026 in West Palm Beach. 🤩Attend my presentation Monday, March 10, board #101. 🤝Schedule a 1-1 with me to talk about your next microscopy projects. #neuroscience

Out today in Neurophotonics, we show that cross-talk between the imaging laser and opsin in all-optical experiments can affect response dynamics beyond what has been accounted for. Imaging conditions subthreshold for evoking spikes can accelerate opsin desensitization: doi.org/10.1117/1.NP...

In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...

#fluorescencefriday distribution of microglia in the whole brain

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

iGluSnFR4 is now available @natmethods.nature.com www.nature.com/articles/s41... Glutamate indicators with increased sensitivity and tailored deactivation rates 🧪

We are delighted to sponsor both the GRC and GRS meetings, supporting innovative science and the next generation of leaders in basal ganglia research. #CoherentCorp #GRCBasalGanglia

❄️ Now I understand why people rave about Winter Conferences. I attended one last week and am still under the influence of the fantastic conversations, presentations, and mountain views. #neuroscience

On my way to BIOS and Photonics West in San Francisco. There will be many interesting presentations from Coherent (see the list under link below). Pick and choose something to match your interests! See you soon! #BIOS26 #PW26 www.coherent.com/events/photo...

🔬 What’s next for ultrafast laser sources in multiphoton microscopy? Let's meet at BIOS on January 18, 2026 | 3:25 PM - 3:40 PM PST | Room 160 (Moscone South, Upper Mezzanine) and discuss! #BIOS26 #PhotonicsWest #UltrafastLasers #Microscopy #Photonics @spie.org spie.org/photonics-we...

Two-photon imaging of pulsating brain activity in a #zebrafish larva that's having a seizure. Credit to Dr. Dominic Burrows. #ZebrafishZunday 🧪

I’m already in San Diego and participating first-hand in a bunch of exciting #sfn25 satellite events!

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word!

#SfN25 is packed with amazing science and networking opportunities. Cannot wait! The power of coming together has never been more important. #Neuroscience #Microscopy #2Photon #3Photon #1Photon

💜 Great day at Harvard Medical School! Don't be sorry if you missed the workshop, customers presentations and tech talks. Reach out with questions.

🚀 Join us at Harvard Med! Discover how miniature multiphoton imaging is enabling neuroscience in freely moving animals. 🧠 Miniature Multiphoton Systems for Neuroscience Workshop 📍 Warren Alpert 236, 220 Longwood Ave 📅 Oct 27 | 12:00–15:00

How does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With Tony Drinnenberg from the Deisseroth Lab (@deisseroth.bsky.social) doi.org/10.1101/2025...

"There's no shortage of reasons these days to be angry or afraid. But look around you right now and you'll see tens of thousands of reasons to keep the faith and keep going. This is the America we know to be possible." —Mayor Michelle Wu, Boston No Kings Rally 🚫👑 #NoKings

The microscopy core at Miami University is searching for a new director. Please consider sharing this job posting! miamioh.wd5.myworkdayjobs.com/en-US/miamio...

‘Economics Nobel prize won by researchers who showed how science boosts growth’ by @philipcball.bsky.social in @nature.com www.nature.com/articles/d41...

Check this out if you're interested in causal neuroscience and/or brain-machine interfaces www.cell.com/cell-reports...

#fluorescencefriday shows the intimate relationship between astrocytes, (cyan) microglia (green) and amyloid plaques (magenta). we find that in APOE4 mice there is much more glia associated with plaques.

Fall and a tail 🐾🐕‍🦺

And we're off to a nice start of #OMIBS2025 Pictures feature course directors @michelleitano.bsky.social and Wes Legant introducing the course and our generous sponsors @leicamicrosystems.bsky.social Evident/Olympus @abberior.rocks Coherent @pacificoptica.bsky.social (1/3)

Enjoy wide two-photon view lighted with Axon 920, 1.2 W

Just landed in Woods Hole for summer courses: a Full Ventana Wide system. pacificoptica.com/ventana/ with a Cousa pacificoptica.com/cousa/ www.mbl.edu/education/ad... www.mbl.edu/education/ad... Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!

The Queen 🇵🇱

Exploring the Brain - One Spine at a Time 🔬 Just chatted with @sainsburywellcome.bsky.social about our latest work, miniaturising two-photon microscopy for neuroscience at @kavlintnu.bsky.social www.sainsburywellcome.org/web/qa/mini-... A few highlights:

Good morning from Maine! #conference

Very nice nature review on emerging three-photon microscopy!