A couple general rules how to deal with non-sense: Stay grounded. A well-placed joke can defuse tension or expose absurdity. You don’t have to fix everything or everyone.

Fall and a tail 🐾🐕‍🦺

And we're off to a nice start of #OMIBS2025 Pictures feature course directors @michelleitano.bsky.social and Wes Legant introducing the course and our generous sponsors @leicamicrosystems.bsky.social Evident/Olympus @abberior.rocks Coherent @pacificoptica.bsky.social (1/3)

Enjoy wide two-photon view lighted with Axon 920, 1.2 W

Just landed in Woods Hole for summer courses: a Full Ventana Wide system. pacificoptica.com/ventana/ with a Cousa pacificoptica.com/cousa/ www.mbl.edu/education/ad... www.mbl.edu/education/ad... Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!

#OCaMP is now on bioRxiv and reagents are available on #Addgene! 🧪 A sensitive orange fluorescent calcium ion indicator for imaging neural activity www.biorxiv.org/content/10.1...

The Queen 🇵🇱

Exploring the Brain - One Spine at a Time 🔬 Just chatted with @sainsburywellcome.bsky.social about our latest work, miniaturising two-photon microscopy for neuroscience at @kavlintnu.bsky.social www.sainsburywellcome.org/web/qa/mini-... A few highlights:

Good morning from Maine! #conference

Very nice nature review on emerging three-photon microscopy!

Going East, again this summer.

Beautiful Saturday

Absolutely gorgeous both shape and color palette

A nice z-stack through cortical layers containing plaques and structures that express vimentin, a cytoskeletal protein. #microscopy #neuroscience #2Photon #fluorescence

We're having a great time at @mblscience.bsky.social Neurobiology, and @nsb-mbl.bsky.social courses! This time excited to showcase multiphoton microscope from Sutter, powered by the Chameleon Discovery LX femtosecond laser from Coherent Corp. #microscopy #neuroscience #2Photon #STEM

Proud to support the next generation of imaging scientists. Here are a few shots of Coherent's ultrafast fixed-wavelength Axon lasers at 780, 920, and 1064 nm, lighting Thorlabs scope-ready for student prepared samples at @mblscience.bsky.social. #Microscopy #Neuroscience #UltrafastLasers #STEM

I told you 🫵

It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵 www.nature.com/articles/s41...

Our favorite pine trees on our daily walk

Hey! I’ll be in the Boston area next week and at MBL consulting on imaging technologies. If you're using multiphoton microscopy in your research, I'd love to hear about your applications and share some of the latest laser developments from Coherent. Send me a msg.

Loved the @neurophotonics.bsky.social summer school, Quebec City and French people. Also got in touch with some people I’ve been meaning to connect with for a while!!

On the plane next to a guy with a running nose. It hurts my ears. Offered a tissue to him but he refused and warned me to continue making the noise.

Here come our new palette of fluorescent dyes. The BD dyes endeaves to balance glowy brightness, robust photostability, and biocompatibility. Let's boost 4D dynamic super-resolution imaging!!! www.nature.com/articles/s41... @spirochrome.com

I'm looking forward to attending, even if just briefly, the 18th Edition of the Frontiers in @neurophotonics.bsky.social Summer School this week at the CERVO Brain Research Center in Quebec City. I have a few openings on Wednesday (June 4). Let me know if you'd like to catch up or show me around!

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week. www.nature.com/articles/s42...

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

Not going well... lots of fruits but leaves are affected by disease caused by the fungus Taphrina deformans 😭

Heartbroken to hear that the @hhmi.org Hanna Grey fellowship competition is being cancelled this year. I poured so much work and creativity into this app and am very grateful for everyone who helped me revise. It is such a difficult time to be a young scientist.

AI is advancing electrophysiology! www.cell.com/cell/abstrac...

Excited to get a hold of my new book! www.simonandschuster.com/books/Super-...

"Science is an investment. We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world." — President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

Hope all goes well this season 🍑

We are super happy to announce the third Workshop of Ideas in Neuroscience! We will once again look critically at assumptions of modern neuroscience: what does it mean that the brain encodes information? Is this a useful approach, or a metaphor that blurs our vision?

#mini2P 🔥 NEW! Pair the compact, fixed-wavelength Axon FL from Coherent with any brand of miniaturized multiphoton microscope. 🚀 Resolve calcium signals in axons, dendrites, and spines — in the 🧠 of freely moving 🐭. 💬 Let’s talk options for your application! www.coherent.com/news/press-r...

I had really great time at #OpticaBiophotonics last week!

#FluorescenceFriday Some favorite transcriptionally-defined spatial domains identified using the 10X Genomics Xenium platform in the mouse brain.

I was happy to see Pope Francis yesterday on TV. Today, the world mourns the passing of Pope Francis. He was a thoughtful leader. He dedicated himself to spreading a peace and compassion. Only good people leave to early. Rest in Peace Pope Francis.

Flying out to San Diego for Optica Biophotonics Congress 2025: Optics in the Life Sciences. See you there? #conference #optics #microscopy #neuroscience

I highly recommend this inspiring new book by Nahum Ulanovsky! A plea for neuroscientists to embrace “Natural Neuroscience”: use emerging technologies to uncover meaningful behavior and neural representations in free-roaming animals exposed to real-world stimuli. mitpress.mit.edu/978026204499...

Patiently waiting for breakfast

I’ve learned to share my dreams with others, and I’m no longer afraid to use that as a test of character and connection. Some people listen, encourage, and offer me the real support. Others dismiss or doubt me—and I found it just as valuable to see. #network

Functional connectomics is a "new kid on the block" that brings structure and function together to uncover general principles of connectivity between excitatory neurons within and across brain areas. Check out accompanying articles in Nature.

Exclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1

The shadow in the bottom left of these pics is the ribbon of our flexible probes. The array is inserted and spans about 1 mm. Here we’re imaging at z = 200um

Columbia Penn Harvard Princeton Brown and now Cornell and Northwestern www.nytimes.com/2025/04/08/u...

We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.

Y'all...there are 3,000 colleges and universities in the US and fewer than TWENTY (20) have taken a stand for higher education and academic freedom. I think they need a little reminder of our core values...don't you think? #standupwithus

Despite what certain people might tell you, ongoing cuts to federal support for science & medical research are not 'targeted' to 'elite' institutions. They are broad in scope, hit state universities, flagships, hospitals, and research institutes all across the U.S. More @ scienceimpacts.org

There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...

Thank you very much @hhmijanelia.bsky.social and @hhmi.org for inviting me to give a seminar! That talk was supposed to be today, Tues Mar 11th. I would have talked about @lafosse.bsky.social's work on neural activation functions (con't below)... But I had to cancel due to the NIH travel ban. 🧪 1/