#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social

Episode #39 in #TheoreticalNeurosciencePodcast: On modeling neural population activity with mean-field models – with Tilo Schwalger theoreticalneuroscience.no/thn39 How can mean‑field models be systematically derived from the underlying microscopic dynamics of individual neurons?

Episode #37 in #TheoreticalNeurosciencePodcast: On reproducibility of modeling and 10 years with the Potjans-Diesmann network model - with Hans Ekkehard Plesser theoreticalneuroscience.no/thn37 How can replication crises be avoided in computational neuroscience?

Thrilled that our paper is out today in Nature! www.nature.com/articles/s4...

I don't often cite The Spectator, but this is quite good.

Episode #33 in #TheoreticalNeurosciencePodcast: On computational neurotechnology for the clinic – with Anthony Burkitt, Nada Yousif and Esra Neufeld theoreticalneuroscience.no/thn33 I hosted a panel debate on the topic at CNS2025 in Florence in July. @cnsorg.bsky.social

Using a new genetically-encoded voltage indicator in an all-optical approach to measure synaptic plasticity in awake behaving mice. Great work by @jacquescarolan.bsky.social and colleagues. Check out www.nature.com/articles/s41...

Check this out if you're interested in causal neuroscience and/or brain-machine interfaces www.cell.com/cell-reports...

Episode #32 in #TheoreticalNeurosciencePodcast: On IIT and adversarial testing of consciousness theories – with Christof Koch theoreticalneuroscience.no/thn32 Christof, a developer of the IIT theory for consciousness, explains IIT and recent testing against the GNWT theory.

Want to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply

X Latin American School on Computational Neuroscience – LASCON 2026 University of São Paulo, Brazil January 5-30, 2026 Application Deadline: October 4, 2025 sisne.org/en/lascon-x/

Our 2nd Array Tomography Workshop will be in November in Buenos Aires and there is still time to apply! Five days of hands-on learning, discussions and talks + gorgeous electron microscopy and immunofluorescence. Focus on simple and affordable workflows. www.arraytomography.org/workshop-202...

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently. Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries. www.biorxiv.org/content/10.1...

Together with @repromancer.bsky.social, I have been musing for a while that the exponentiated gradient algorithm we've advocated for comp neuro would work well with low-precision ANNs. This group got it working! arxiv.org/abs/2506.17768 May be a great way to reduce AI energy use!!! #MLSky 🧪

Episode #29 in #TheoreticalNeurosciencePodcast: On the philosophy of simplification in computational neuroscience - with Mazviita Chirimuuta and Terrence Sejnowski theoreticalneuroscience.no/thn29 What are the pitfalls when simplifying? Panel debate at FENS meeting in Oslo. @fens.org

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.

How do we think, feel, remember, or move? 🧠 Collaborating with @unigoettingen.bsky.social , @deschutteroist.bsky.social models the vesicle cycle, a driving force behind neurotransmission, to reveal more about how our brains work. For more details 👉 www.oist.jp/news-center/...

Does neural computation feel like something? In our new paper, we explore a paradox: if you replay all the neural activity of a brain—every spike, every synapse—does it recreate conscious experience? 🧠 doi.org/10.3389/fnin...

Episode #28 in #TheoreticalNeurosciencePodcast: On whole-cell modeling of bacteria – with Markus Covert theoreticalneuroscience.no/thn28 In 2020 a model of E. coli with 10000 equations and 19000 parameters was presented by the guest. How are such models made?

Delighted to join the Royal Society of London for Improving Natural Knowledge! It's been in the news since 1660, and more so lately. Grateful to all my collaborators over the years.

This is completely false. Even the largest university endowment cannot sustain a large-scale scientific research enterprise. In my 25 years at Princeton, the most monumental fund drive for research raised a total of $325M. Federal research here costs $200M per year, every year.

Check out our latest profile! Dr. Eve Marder studies the stability and flexibility of neural circuit function. Follow the link below to learn more! www.storiesofwin.org/profiles/202... #StoriesofWiN #WomenInNeuroscience #WomenInNeuro

"Science is an investment. We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world." — President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr

Linking function and structure at scale with X-rays - and several times over. Massive congratulations to the team ‪@yuxinzhang.bsky.social‬, @carlesbosch.bsky.social, @apacureanu.bsky.social @esrf.fr, @crick.ac.uk and all our collaborators.

Episode #27 in #TheoreticalNeurosciencePodcast: On construction and clinical use of multipurpose neuron models – with Etay Hay theoreticalneuroscience.no/thn27 How are multipurpose neuron models made and used to explore differences between healthy and depressed brains?

Nice mood boost etched into marble at the Mellon Institute in Pittsburgh. Seen yesterday at the moving, inspiring celebration of Carl Olson's life and career.

Super happy that our papers #2 and #3 from our 3-person lab just went online on bioRxiv! First large-scale 3D EM dataset from mouse hippocampus CA1 www.biorxiv.org/content/10.1... - check out the beautiful data on webknossos wklink.org/7023 ! …

Check out: physics-based modelling of locomotion in Drosophila

Both scary and exciting

a friend sent me this one

I honestly think LLMs are very useful tools, but this kinda shit shows the real danger with these models: Stupid people with important roles will use them for purposes they are not well suited for.

Episode #26 in #TheoreticalNeurosciencePodcast: On the population code in visual cortex – with Kenneth Harris theoreticalneuroscience.no/thn26 How do groups of neurons together encode information to balance the needs for efficiency and robustness?

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks. Beautiful work by @stefanieliebe.bsky.social

A principal puzzle in neuroscience is how to relate neuronal activities to control of behavior. I will present ideas on using the climbing fiber input to estimate contributions of the various neurons in the cerebellum. That is, to understand what a neuron does, it is useful to look at its teacher.

✨ Announcing a new glutamate indicator - iGluSnFR4! ✨ Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses. More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1... 🧠📈

Figured I’d hop on here today for the 15th anniversary of the Affordable Care Act. With everything going on right now, it’s easy to feel like regular folks can’t make a difference – but the ACA is a reminder that change is possible when we fight for progress.

🚨I converted the list of terminated #NIH grants (as of 3/22) into a google sheet. I added activity codes and award jurisdictions (see tabs for grant count and $ by each). Note this HHS list likely does not include all planned/completed terminations as of this date.🚨 Please use, share and distribute!

We shall postpone fighting on the beaches, we shall keep an eye on the landing grounds, we encourage everyone else, should the right circumstances come, to fight in the fields and in the streets, we shall eventually retreat to the hills; we shall never explicitly surrender.

Same thing will happen with education and basic research. We’re about to find out that what really made America great was the friends we made along the way 😔🥀💔

Neuroscience Unleashed in Jerusalem July 20–24 2025 An international graduate school on consciousness, NeuroAI, brain-machine interfaces, psychedelics & organoids. Graduate students & postdocs: Apply by April 19 2025 iias.huji.ac.il/29LifeSci RT to help spread the word 🙏

So many amazing summer schools this year. Here is a new one (Neuroscience Unleashed, AI, Consciousness, LLMs) which promises to be pretty great: iias.huji.ac.il/29LifeSci

When hundreds of NIH grants are revoked, what is lost? Not just knowledge and cures. Human capital as well. Rigorous peer review, thousands of person-hours of effort, and degradation of a world class scientific process. A deep deep dive: open.substack.com/pub/donmoyni...

The Oldenburg Lab is looking for another postdoc! The news these days is scary but we're pushing on. If you want to use Holographic Optogenetics to understand neural codes, the motor system, or something else fun let me know. We have federal and non-federal (aka stable) funds. oldenburglab.com

Come and visit Mechelen. @stadmechelen.bsky.social @auditorynerves.bsky.social, as usual, you were ahead of the curve. www.theguardian.com/travel/2025/...

By attacking science: We are less safe because science informs national security and medical care. We are less prosperous because science drives innovation and economic benefit. We are less free because science and democracy depend on the liberty to ask questions, and seek and share knowledge.

Today I'm filled with admiration for my university's president, Chris Eisgruber. He's standing up for Columbia and for universities as a home for freedom of ideas, debate, and thought - free of government attack. www.theatlantic.com/ideas/archiv...

If you want to move to Europe for no particular reason...

The International Brain Laboratory reproducibility platform paper is now published at eLife. An amazing effort by many different labs and individuals to understand and improve the reproducibility of electrophysiological measurements in mice. 🧠