From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.

It is with a heavy heart that I share the unexpected news that our colleague, friend, and mentor Daniel Madison passed away on Thursday, October 9.

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism

Back from a trip and I found this unintentional present I left myself

It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!) thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.

Ultramicrotomy escapism: trimming blocks and enjoying the shapes and colors 💕

Our 2nd Array Tomography Workshop will be in November in Buenos Aires and there is still time to apply! Five days of hands-on learning, discussions and talks + gorgeous electron microscopy and immunofluorescence. Focus on simple and affordable workflows. www.arraytomography.org/workshop-202...

We're thrilled to announce the largest private gift in our 137-year history: a $25 million unrestricted donation from MBL Whitman Scientist Mark Terasaki. His extraordinary generosity will bolster our renowned research and education programs. 🔬 Learn more: bit.ly/452WL1m

Excited to announce registration to the next Array Tomography workshop in Buenos Aires is now open! #volumeEM See our AT website page for more information ⬇ www.arraytomography.org/workshop-202...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

What happened to the pursuit of truth? rupress.org/jgp/article/... - Eve Marder, on point...

Happy to share a new biorxiv manuscript with @owen-lab.bsky.social where we “slice and dice” synapses with array tomography and find subclasses with different glutamate receptor composition 🧪

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...

Layers Upon Layers bryanwjones.com/2020/06/laye... #SciArt #retina

Get a free NIH BRAIN Initiative art calendar to prep for 2025: catalog.ninds.nih.gov/publications... . I'm proud to say that the cover is a piece we created from the DTI imaging of a subject in the BRAIN funded depression DBS study we reported last year: go.nature.com/48lmlzC 🧪🧠

Cortical interneurons learn on the job! Speculated this was true a decade ago! Sherry Wu and Min Dai finally provide evidence! www.biorxiv.org/content/10.1...

This is fun 🦋 With help from Scholar Goggler scholargoggler.com

Best thing you could watch in 2016 and best thing you can watch today. RIP Thomas Reese

Celebrating the small (70 nm) victories today - look at these perfect serial sections that I cut! 🧪 the joys of #arraytomography

I'm here, who else?

Time for some of my favorite images with immunofluorescence array tomography: this one is human cortex, and the yellow fluff around the blue nuclei are lipofuscin granules that accumulate with aging. Lipofuscin in this image comes for free - no label needed because it is autofluorescent!

Delicious & unique array tomography cake from the Array Tomography Workshop in Munich 2024. Thank you!

Color-coordinated EM. Chapter 2. Autumn synapses with #webknossos

There are places / communities / ecosystems that are so difficult to leave and keep pulling you back Woods Hole, MBL

Found in the Lillie library, MBL - interesting dynamics of the languages used in early zoological literature and here's the actual reference: doi: 10.3897/zookeys.550.10041

Perfect occasion for my first post here: Lab with a view - talk done - great to be back at MBL!