Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease www.nature.com/articles/s41... via @natmed.nature.com #Alzheimers #dementia #publichealth #exercise #fitness #geriatrics #GeriSky

We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour... How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Hey #AAIC25 ! Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠 Join me on poster 430! @ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social

🧾 Poster #487 Data-Driven Characterization of Heterogeneous Brain Atrophy and White Matter Hyperintensity Progression in FTD (Amelie Metz @ameliemetz.bsky.social ) Tuesday, July 29

Honoured to have been awarded the Vanier Scholarship — pretty psyched about it. Big thanks to everyone who’s helped me get here!

Really excited to share this new preprint on the dynamics of alpha-synuclein spreading by Dr. Stephanie Tullo in our group. This was a long term labour of love spanning the pandemic, experimental work, and in silico modelling www.biorxiv.org/content/10.1... See more below ⬇️

The REC Steering Committee is excited to host multiple opportunities for early career researchers across the #NIAfundedADRC Program to gather at #AAIC2025! RSVP to connect w/other scholars and leaders from #NIA, #NINDS, and the ADRC Program: uwashington.qualtrics.com/jfe/form/SV_...

In @ohbmossig.bsky.social's first Open Datasets Special Issue paper, Wearn et al. introduce the OHBM Time Machine, a freely accessible archive of Annual Meeting content on YouTube: doi.org/10.52294/001... @alfiewearn.bsky.social @sitek.bsky.social @sofievalk.bsky.social @stephforkel.bsky.social

wonderful opportunity for junior faculty

🚨New preprint 🚨 TL;DR Supporting cerebrovascular and mental health, along with staying cognitively engaged, may help preserve brain function and delay cognitive decline and dementia. @dzne.science

After 3 years of "just one more analysis", our work on WMH pathophysiology is finally out! Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling doi.org/10.1101/2025...

Sex Differences in Vulnerability to Tau Pathology: Impact on Cognitive Decline https://www.medrxiv.org/content/10.1101/2025.05.25.25328324v1

Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer's disease https://www.medrxiv.org/content/10.1101/2025.05.30.25328630v1

Vascular risk factors mediate the relationship between education and white matter hyperintensities https://www.medrxiv.org/content/10.1101/2025.06.03.25328899v1

Happy to see my first first-author paper in Imaging Neuroscience (along with @fmrib-karla.bsky.social and @nichols.bsky.social): Characterising ongoing brain aging and baseline effects from cross-sectional data doi.org/10.1162/IMAG...

Parkinson's disease links to ultra-processed foods and pesticides www.nytimes.com/2025/05/07/w... www.nytimes.com/2025/05/07/w... jamanetwork.com/journals/jam...

Chemical additives in plastics (phthalates) and cardiovascular mortality www.thelancet.com/journals/ebi...

Our Department of Global and Public Health within McGill University School of Population and Global Health is recruiting an Assistant Professor (Tenure Track). Apply now! 👇 mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Reducing the risk of all-cause dementia with intensive blood pressure control, the results of a cluster randomized trial in~34,000 participants. @naturemedicine.bsky.social www.nature.com/articles/s41...

Hey #ADPD2025 , I'm happy to present our work on characterizing brain atrophy and cerebrovascular pathology in Frontotemporal Dementia subtypes! Tomorrow, April 5, 9:40am, Hall F2, session: Mechanisms and Clinical Trials in FTD, ALS, and Neurodegeneration 02

There's a stream of excellent papers in @apertureohbm.bsky.social being published! Check them out: apertureneuro.org Submit your own +code +data +open science +imaging studies+ Quick turnaround, a devoted ed board, and lowest APC around. And you'll support @ohbmofficial.bsky.social share pls!

Metz et al. report that a study combining MRI brain atrophy and clinical data using machine learning achieved 89% accuracy in classifying frontotemporal dementia subtypes. Please read at:https://buff.ly/uGmX2fg @DadarMahsa @YasharZeighami @sylv_villeneuve @sducharme66

😋 @dadarmahsa.bsky.social @yasharneuro.bsky.social @sylviavilleneuve.bsky.social

👏 why am I just hearing about this amazing resource? devMSMs: Implementing Marginal Structural Models (MSMs) Structural Modelswith Longitudinal Data github.com/istallworthy...

Join us for the next edition of Neurogenesis on March 26 at @theneuro.bsky.social, featuring talks by @danasmall.bsky.social and @yasharneuro.bsky.social! Learn more about their research, partake in the Q&A and network with peers at the post-event reception. 🧠 Register now: mcgill.ca/x/iw5

Our new registered report by @kaylahannon.bsky.social compared 6 subtyping approaches for depression. Although most had good stability and sensitivity, there was no agreement between resulting patient groupings. Is it time to rethink our approach to depression heterogeneity? doi.org/10.1016/j.bp...

Tenure track position in pharmacology or toxicology at McGill, in Montreal!!! www.nature.com/naturecareer...

📢 We have a new #NeuroAI postdoctoral position in the lab! If you have a strong background in #NeuroAI or computational neuroscience, I’d love to hear from you. (Repost please) 🧠📈🤖

This cookbook is long overdue, and it starts with my favorite Buckheit and Donoho quote! Inspiring work by @jtsense.bsky.social @efratshimron.bsky.social Moritz Zaiss and colleagues link.springer.com/article/10.1...

Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025... How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️

If you were wandering, how variable are human brains? Fresh off the press!

Fonov and Collins investigate optimal sample sizes for creating representative average anatomical brain templates: doi.org/10.52294/001... @fmri-today.bsky.social @mallarchak.bsky.social @ohbmofficial.bsky.social

📣 Don't miss the CIC lecture by Nicola Palomero-Gallagher on March 5 @2pm! buff.ly/41ydnNL 📣 Venez participer le 5 mars au séminaire du CIC avec Nicola Palomero-Gallagher @14h! buff.ly/41iWlC3

Excited to share that the first project of my PhD was published in 🧠 @braincomms.bsky.social 🧠 !! We showed that machine learning can effectively differentiate frontotemporal dementia subtypes combining brain atrophy and cognition 🎉 doi.org/10.1093/brai... (1/10)

Frontotemporal dementia subtyping using machine learning, multivariate statistics and neuroimaging academic.oup.com/braincomms/a...

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study - onlinelibrary.wiley.com/doi/10.1002/...

Trainees: Showcase your research on brain health at #HBHLSymposium2025 with a poster or flash talk! 🏆 Open to grad students at @mcgill.ca, @umontreal.ca, @polymtl.bsky.social, @westernu.bsky.social & UBC whose research aligns with HBHL's themes. 🧠 Apply by March 21, 2025: mcgill.ca/x/ikv

please retweet this ad for a tenured-research position in fMRI at ultra-high. Join us!

📣 Don't miss the CIC lecture by Clara Moreau on February 12 @2pm! https://buff.ly/4g3IfcY 📣 Venez participer le 12 février au séminaire du CIC avec Clara Moreau @14h! https://buff.ly/4gVnPEo

I'm currently interested in recruiting a master's student for this Fall 2025 to the CANAL lab. We're about to launch an MRI project focused on the intersection of #aging, #hearing, and #cognitivereserve Please get in touch! www.canallab.ca/contact #neuroscience @carleton-cogsci.bsky.social

New opportunity posted: Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal can-acn.org/principal-in... #neurojobs @CRA_CHUSJ

Apathy progression is associated with brain atrophy and white matter damage in Parkinsos disease https://www.medrxiv.org/content/10.1101/2025.01.22.25320946v1

Finally out from the lab! 🎉 Great work by @albrzez.bsky.social with @dadarmahsa.bsky.social @mallarchak.bsky.social @roqamoqa.bsky.social and Yasser Iturria-Medina

Don’t forget to check the full paper for more details! 📃 Thanks to my advisors @dadarmahsa.bsky.social and @yasharneuro.bsky.social, and to everyone who contributed to this work ( @mallarchak.bsky.social + bsky-less Yasser and Roya ) for making it possible! 10/10

🧠 allometry is not heavily impacted by TIV and the sex differences are subtle 🧠 TIV might impact the performance in “verbal and numerical reasoning”, “working memory”, and “non-verbal reasoning” domains 9/10

In summary: 🧠 estimated sex differences in aging models decrease when females and males have the same TIV and more subtle patterns of sex difference emerge once the impact of TIV is removed 8/10

Finally, we explored cognitive functioning with the data included in the UKBB dataset. We found that TIV played a role mainly in the cognitive domains of “verbal and numerical reasoning” and “working memory”. 7/10