My poor laptop wishes I learned how to use the cluster earlier, but it’s sacrifice was not in vain! We learned some important things about the breast cancer tumor microenvironment, described in our paper published today: www.cell.com/cell-reports... Here's the 🧵

Man; @typst.app is so good! That's all; that's the skeet.

One of the most rewarding things is when one of your students graduates with a PhD! Congratulations to Dr @allanlui.bsky.social! @caldaslab.bsky.social rejoices!!

An enormous honour! Thank you @embo.org and @helloeacr.bsky.social! This talk was only possible because of the amazing talent of @caldaslab.bsky.social and past #Caldasians!

@carloscaldas1960.bsky.social and the Caldasians will always #KeepResearchCurious and never stop doing good science! #EACR2025 @helloeacr.bsky.social

Riccardo Masina a junior Academic Clinical Fellow that has not even started his PhD giving an oral presentation at #EACR2025! Thank you @helloeacr.bsky.social! @caldaslab.bsky.social is made of young scientific superstars! Walking the walk on ML to find predictors of drug responses!

Extraordinary #EACR2025! Who could have guessed this number of exhibitors 5-10 years ago?! @helloeacr.bsky.social is doing amazingly well! So proud to be a Board member!

Outstanding talk by @hrazaalilab.bsky.social! @caldaslab.bsky.social delighted to be walking the walk together with him and @paulpharoah.bsky.social!

@caldaslab.bsky.social and ##Caldasians at #EACR2025! Walking the walk!

snDNAseq of 40,000 cells from 140 tumors from #METABRIC. @mauriziocallari.bsky.social and @sc10021.bsky.social will soon write a major papers from this work! @caldaslab.bsky.social continues to produce outstanding science!

@allanlui.bsky.social has discovered a synthetic lethal hit for ER+ breast cancer driven by ZNF703 amplification! Major stuff! @caldaslab.bsky.social walking the walk!

With @paulpharoah.bsky.social- a great friend and amazing collaborator! Also @stephensammut.bsky.social another super star! What @scicambridge.bsky.social has lost...

Excited to be sharing the culmination of my PhD work at #EACR2025! The support of everyone @caldaslab.bsky.social over the past 5 years and @carloscaldas1960.bsky.social was what made this possible!

Outstanding work! @idoamitlab.bsky.social rocks! Congratulations

@yardenasamuels.bsky.social opening #EACR2025! Amazing grace! @eacr.org is very lucky to have Yardena as its president!

Excellent presentation from Carla Oliveira on HDGC. Fantastic to see one of my first PhD students now a world leader in her work. #Caldasians rock #EACR2025! @caldaslab.bsky.social

#EACR2025 has started! Now João Barata from @gimmfoundation.bsky.social! @helloeacr.bsky.social rocks!

Last @caldaslab.bsky.social production: pubmed.ncbi.nlm.nih.gov/40359107/

I am excited to share the latest publication from the Nguyen, Caldas @carloscaldas1960.bsky.social and Rueda labs @ruedalab.bsky.social. This was a massive effort from a fantastic team and I’m grateful to everyone on the paper for their work on this project! doi.org/10.1016/j.ce... #bcsm #PDTX

Incredible study lead by @nguyenlab.bsky.social showing the potential of an in vivo system capable of robustly tracing the lineages of individual cells as they propagate in a #PDX tumour! Very happy to have been able to contribute to this herculean effort, and can't wait to see what comes next!

"I am satisfied with how bullying and harassment are addressed in my department … 27 %" Just 27% !fu@c$! Many results from Cambridge Uni's Staff Survey are beyond the beyond The kind of things you'd put in the ‘no way’ file. Except it's happening now Blog posting here 21percent.org?p=1716

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

RNA xkcd.com/3056

Couldn't agree more! Dismantling the NIH is an utter travesty To biomedical scientists in the rest of the world, it sends a clear message: Your talents are not wanted here. Losing the ability to attract the best and the brightest will be the death of American scientific exceptionalism

Sign it!

In ILC, after neo-adjuvant therapy, RCB retains prognostic value. @caldaslab.bsky.social and @stephensammut.bsky.social happy to have contributed. Walking the walk. www.nature.com/articles/s41...

These AG1 ads are everywhere. Here's the "dark truth" about it. www.youtube.com/watch?v=59Vf...

It’s been buried in all the news today, but every scientist in the US should pay attention to this: Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪

Fantastic overview of AI in biology! www.science.org/doi/10.1126/...

Totally crazy! If Congress does not stop this, biomedical research in the USA is in serious trouble.

In case you have not seen it. The latest paper from @caldaslab.bsky.social in @theaacr.bsky.social. Xenografts as avatars! aacrjournals.org/cancerres/ar...

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects. 📄 nature.com/articles/s41... 🌐 search.foldseek.com

I am really happy to share that I successfully passed (minor corrections) my PhD viva yesterday! A big thank you to everyone who has supported me throughout the last 4 years. Thank you to my examiners Jeffrey Wedt & a Paul Kirk and or a great viva and interesting discussion! #PhDone

Congratulations Dr Daniel Guerrero-Romero!! It is fantastic to see another PhD out of @caldaslab.bsky.social! This one on the mathematics of breast cancer xenograft growth.

The scientific gift that keeps on giving are the people I’ve met through science.

DeepSeek's open AI model is giving scientists worldwide the opportunity to train custom reasoning models designed to solve problems in their disciplines. https://go.nature.com/4hxoRGD

🧪 If I were Canadian PM I would immediately: 1. Create a new $15B science fund 2. Offer any credentialed US scientist funding for lab startup and replacement of NIH grants if they move to Canada 3. Immediate permanent residency 4. Citizenship after 2 years Overnight a science superpower

Happy Lunar New Year 2025 @science.org

Unless our leaders wake up, the future is bleak! Where are the inspirational leaders the sector direly needs?? www.spectator.co.uk/article/can-...

Distopian- what is the meaning? This: www.science.org/content/arti...

Thrilled and proud to be part of the Rueda Lab! This is a huge achievement for Oscar Rueda and the entire team. Excited to see the outstanding results from this groundbreaking research initiative! @mrc-bsu.bsky.social #CancerResearch #AI #MachineLearning 👏

Fantastic news! #Caldasians are part of it! Oscar Rueda!! @caldaslab.bsky.social www.mrc-bsu.cam.ac.uk/news/ps10m-f...

Absolutely! @helloeacr.bsky.social is organising a superb meeting! And Lisbon is a stunning city! Don't miss #EACR2025!!!

A dreadful tale.

This is a story about an appalling research misconduct investigation following baseless allegations brought by senior individuals. There was no research misconduct, but the collateral damage was substantial. However, those making false allegations profited.

New blog posting A story of precarity at a Russell Group University There were 25 people employed on the grants; 3 senior research associates, 10 research associates, 6 research assistants & 6 grad students This is what happened to us 21percent.org?p=1371

Couldn't agree more! We're already a quarter into the 21st century, and it's been more than 50 years since the first PCs. Why haven't we figured out how to collect data cleanly? 🤦‍♂️

@natmedicine.bsky.social is also now on Bluesky! 🎉 You can follow all of our journals with our starter pack.