The first report of ML to integrate multi-omic data to generate a therapy response predictor. In a little over 3 years now cited >300 times in Web of Science! Incredibly proud @caldaslab.bsky.social and @stephensammut.bsky.social!! www.nature.com/articles/s41...

Nice to have our paper highlighted! @caldaslab.bsky.social always walking the walk! www.uhnresearch.ca/news/rare-ca...

Incredibly humbled and honoured to have been awarded the 2025 Research Prize from @thelisterinstitute.bsky.social. ❤️ 🧬 We’re harnessing high-resolution molecular profiling + AI to uncover how cancer disables the immune system and find ways of restoring it. @icr.ac.uk #bcsm #ai #CancerResearch

Our warmest congratulations to Dr Stephen John Sammut, who has been awarded a highly prestigious research prize from @thelisterinstitute.bsky.social 🎉🏆 These awards aim to make a significant difference to the research work of scientists in the early years of running their own groups.

Huge congratulations to Dr Stephen-John Sammut from the Breast Cancer Now Toby Robins Research Centre at the ICR, who's been awarded the BACR/AstraZeneca Young Scientist Frank Rose Award for 2024! 👏 @astra-zeneca.bsky.social @breastcancernow.bsky.social @stephensammut.bsky.social #BACR2025 #BACR25

Lentiviral barcoding used to track the clonal growth of over 20,000 single-cell-derived clones in 110 xenografts from 26 patient-derived breast cancer xenograft models. Beautiful work @nguyenlab.bsky.social!!

A new Science summary spotlights a paper by CSHL’s Tobias Janowitz and colleagues that uncovers a neural circuit linking inflammation to reduced motivation in a mouse model of cancer cachexia. Check out the Science summary here: www.science.org/doi/10.1126/... #Cachexia #ScienceMagazine

Online now in Cancer Discovery concurrent with the #AACR25 Opening Plenary, by plenary speaker Paul Mischel: A Guide to Extrachromosomal DNA (#ecDNA): Cancer's Dynamic Circular Genome doi.org/10.1158/2159...#AACR25

ecDNA @theaacr.bsky.social Paul Mischel from Stanford. In breast cancer ecDNA is the main mechanism of amplification of the ER+ oncogene we co-discovered ZNF703! @caldaslab.bsky.social

dATAC: our new method for simultaneous very high quality whole genome sequencing and chromatin accessibility profiling of single cells. We used dATAC to trace epigenome clonal evolution in colon cancer. Devised by the extraordinarily talented @maxmossner.bsky.social www.biorxiv.org/content/10.1...

Amazing work @ruedalab.bsky.social !!

Excited to share our latest work on monitoring response to treatment using ctDNA and shallow WGS using a Bayesian Model developed by Solon Karapanagiotis with @Carloscaldas1960.bsky.social, Emma Beddowes and @mortegaduran.bsky.social febs.onlinelibrary.wiley.com/doi/full/10....

1/n Fantastic to see this published. Anticipatory genomics demonstration: ctDNA and ML to predict CT progression! Well done @emmajb001.bsky.social and @mortegaduran.bsky.social! Great collaboration of @caldaslab.bsky.social with @ruedalab.bsky.social! #DETECT started by @sj-dawson.bsky.social!

Join Our Team! We're looking for a #computational #postdoc to join our group @icr.ac.uk in Chelsea #hiring We are using single-cell methods to model breast tumour evolution during chemo + immuno-therapy, using serial tumour samples More details: jobs.icr.ac.uk/vacancies/11... #bcsm

Aspirin may enhance the immune response against cancer metastasis in mice, according to research published in Nature. The authors suggest that the findings could aid the development of effective anti-metastatic immunotherapies. https://go.nature.com/3F3GWOB 🧪

📢 Our work just published in @naturecomms.bsky.social @natureportfolio.nature.com! What is driving #response to #targeted #treatments in HER2+ER+ #breastcancer? How is the tumour ecosystem affected by treatment? Find the answers in our paper 👉 rdcu.be/ecbVR Key points below 👇

In ILC, after neo-adjuvant therapy, RCB retains prognostic value. @caldaslab.bsky.social and @stephensammut.bsky.social happy to have contributed. Walking the walk. www.nature.com/articles/s41...

@caldaslab.bsky.social proud to contribute to this! ML/AI to quantify CD31 IHC of blood vessels in breast cancer! Well done lead author Tristan Whitmarsh! pubmed.ncbi.nlm.nih.gov/39905431/

Important translational piece from @icrlondon.bsky.social and Brisken lab. Yet again #METABRIC being used to develop/validate tool! @caldaslab.bsky.social research continues to have huge impact! Walking the walk! www.icr.ac.uk/about-us/icr...

We published this exactly 3 years ago. Already Highly Cited (250 citations on WoS!!). Thanks to @stephensammut.bsky.social @ercresearch.bsky.social @cruk-ci.bsky.social @caldaslab.bsky.social Pioneered use of ML/AI for multi-omic data integration. Walking the walk! www.nature.com/articles/s41...