We’re unwrapping a new method today at @mskcancercenter.bsky.social. Led by Sydney Blattman, Nabih Maslah, and @austinv11.com with @danapeer.bsky.social, @ronanchaligne.bsky.social and @10xgenomics.bsky.social, we present GIFT: Genotyping In Fixed Transcriptomes www.biorxiv.org/content/10.6... 1/n

How is cumulative medical imaging in childhood associated with cancer risk? NEJM Editorial Fellow Katerina Lin, MD, summarizes a recent retrospective cohort study involving 3 million children. Read the full study: nej.md/41YXEHD #Hematology #Pediatrics

Just updated my HHMI Gilliam Fellowship application guide for the 2026 cycle. Big changes this year: international PhD students and MD-PhDs can now apply, and there's a new postdoc pathway extending HHMI support up to 7 years total. www.yaelcourtney.com/resources-an...

After a fantastic MGR today, we are thrilled to welcome Dr. Ross Levine back for our #hematology seminar tomorrow - very thankful to Ross for such & engaging & fun visit! #MPNsm @stanforddeptmed.bsky.social @rosslevinemd.bsky.social @mskcancercenter.bsky.social

Check this out, Californians! “A fellowship for late-stage postdoctoral scientists who have made meaningful discoveries and are ready to envision an entrepreneurial future.”

Really enjoyed participating in this podcast @bloodjournals.hematology.org on new #targetedtherapies in #MPN including #mutantcalreticulin #MPNsm @stanforddeptmed.bsky.social @ash.hematology.org @mpnrf.bsky.social @stanfordmedicine.bsky.social

A thought about job adverts. I assume seeking "exceptional" individuals selects for specific character traits (eg self confidence). My goal is to get candidate with best potential, even if they don't yet think of themselves that way. What words do you use to encourage the widest pool of applicants?

This great idea inspired a better one: a cold open! Just start talking about your subject, then on slide 3 it's like, "Live from this conference, it's me talking about ant eye evolution!" #AcademicSky

Walk with Me: Carolyn Bertozzi, Nobel Prize–winning chemist at Stanford, uses chemical biology to understand disease and develop new treatments. Hear what sparked her love of science—and her dream superpower. stan.md/3O4mjqi @carolynbertozzi.bskyverified.social @stanfordchemistry.bsky.social

Atlas of predicted protein complex structures across kingdoms www.nature.com/articles/s41... www.biopredictnavigator.cn

“When I walk into a lab meeting, I am not burdened by twenty years of accumulated knowledge about signal transduction pathways. I am free to ask the questions that no one else will ask, such as “What if you just skipped that step?” and “Have you tried doing it faster?” and “What is a kinase?” “

Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders

lots of jarring statistics and heartbreaking stories I could share from this story, but this particular anecdote made me tear up when @jonathanwosen.bsky.social first shared this story with me For more details from our survey of ~1000 nih-funded researchers, read the report below

Honored to contribute to @bloodjournals.hematology.org "New Wave of Targeted Therapies in #MPN" review series curated by Dr. Jason Gotlib, thankful to my awesome co-author Dr. Gabriel Salzman! Article link: lnkd.in/gBjUi4R9 @stanforddeptmed.bsky.social @ash.hematology.org @mpnrf.bsky.social #MPNsm

Our @statnews.com survey of NIH-funded researchers drew nearly 1,000 responses from 45 states (plus DC and Puerto Rico). Here's a short thread on 5 scientists' whose labs and lives have been deeply impacted by federal policies 🧵

We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)

🦖 The Plasmidsaurus Merch Store is officially OPEN! To celebrate, we’re launching Merch Madness, a 3-week tournament of challenges to win mystery merch. Round 1: In 5 words or emojis only, tell us: What are you currently sequencing? 🧬👇 🛒 Plus, grab your favorite gear: merch.plasmidsaurus.com

Genuinely just bonkers to watch the USA do this to one of the most successful and innovative hubs of scientific research the world has ever seen. All those years of Free Speech On Campus debates and it turns out they actually wanted less cancer research. Absurd.

“Moderna CEO Stéphane Bancel responded in a carefully worded statement that sources said was written and deleted nine times while laying under a weighted blanket listening to Olivia Rodrigo.”

No-cost workshop opportunities for grad students, postdocs, & trainees! Our Janelia Research Campus is accepting applications for 3 specialized, intensive workshops with presentation & networking opportunities. Accommodations, meals, & travel expenses covered: bit.ly/4roghP6. 🧪

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

New comic! Small groups of animals can be unpredictable, yet sheepdogs and their handlers direct them with style. The study just came out in Science Advances with a beautiful, mid-stride sheepdog on the cover! Congrats to the authors, Tuhin Chakrabortty (featured in the comic) and Saad Bhamla.

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Incredible

New and competitive renewal awards The fiscal year 2026 curve still lies well below the other curves. 1189 awards have been made in fiscal year 2026 compared to 2546 in fiscal year 2024 and 2322 in fiscal year 2025 through that same date (March 6th) 3/4

AF2BIND also recovered about half of liganded Cys residues in a chemoproteomics dataset (by predicting a nearby pocket to the Cys), showing good synergy. The missed pockets point to new opportunities to better train predictors on new data involving cryptic or composite pockets. Need more data!

For a deeper dive, I gave a talk on AF2BIND recently at the MIA series at the Broad Institute. Check it out! Also check out Primer by talented student Ben Fry @benf549.bsky.social (not directly involved in this work). www.youtube.com/watch?v=Cjby...

A public database of binding-site predictions in the human proteome and a google colab notebook to use the model yourself can be found here: github.com/sokrypton/af...

Just out in @natgenet.nature.com: Research led by Dr. Omar Abdel-Wahab of MSK & Dr. Kelly Bolton of WashU Medicine offers a new method to prevent the development of chemotherapy-induced leukemia — one of the most lethal complications of cancer therapy for solid tumors. www.nature.com/articles/s41...

Excited to share our new preprint: “A post-translational regulatory map of chronic antigen-driven human T cell dysfunction.”! www.biorxiv.org/content/10.6...

Go get ‘em @warren.senate.gov

Vinay Prasad is leaving FDA (again). www.wsj.com/health/healt...

Ohh, awesome! I was actually wondering about this exact thing recently. It's super helpful to have data to answer the question.

Very excited to have been awarded a Cancer Grand Challenge grant as part of team REWIRE-CAN @cancergrand.bsky.social to develop new approaches to combat cancer #plasticity. Our goal: to see all #colorectalcancer patients become colorectal cancer survivors.

Congratulations to MSK's Dr. Andrea Cercek and Dr. Luis Diaz for being accepted into Round 1 of @statnews.com's #STATMadness. Vote for their team now: https://bit.ly/3FfcuRu

Congratulations to MSK's Dr. Viviane Tabar and Dr. Lorenz Studer for being accepted into Round 1 of @statnews.com's #STATMadness. Vote for their team now: https://bit.ly/3FfcuRu

An ‘off-the-shelf’ neoantigen #vaccine shows safety and immunogenicity in people with #Lynchsyndrome, advancing hopes for preventive cancer vaccines. News & Views from Zsofia Stadler, Yonina Murciano-Goroff @ Memorial Sloan Kettering Cancer Center https://www.nature.com/articles/s41591-026-04248-2

T-cell engagers for autoimmune disease. Listen to Ken Song, CEO of San Diego-based Candid Therapeutics, on The Long Run podcast. Sponsored by @alphasenseinc.bsky.social & Dash Bio. timmermanreport.com/2026/03/t-ce...

we did an immunofluorescence experiment for T cells. if you zoom in you can see it worked (cells are stained) but we had a lot of antibody aggregates (super bright blobs that don't seem to be cells- some not even on the tissue). any tips on how to avoid having such aggregates?

YES

Reposting for our team riding in @cycleforsurvival.bsky.social this Friday. Still time to donate using the link below! Every dollar goes to support patient-facing rare cancer research! Donate here: shorturl.at/U92Sc