Exciting new work from Barna Lab @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data go.nature.com/49O5INm rdcu.be/d8L1u

Our cross-journal call for paperss on targeted protein degradation is still open for submissions! We welcome submissions focusing on the design, development, and application of targeted protein degradation modalities. @commschem.bsky.social @naturecomms.bsky.social www.nature.com/collections/...

MicroRNAs From their role in cancer jci.org/articles/vie... to Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity sciencedirect.com/science/arti... + explainer nature.com/articles/d41...

A study in Nature Immunology defines a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveals important insights into the mechanisms by which vaccines induce durable immunity. 🔒

What’s new in #Antihypertensive therapies? 📍Aldosterone synthase inhibitors 📍Angiotensinogen targeted therapies 📍GLP1/GIP receptor agonists 📍Natriuretic peptide 1 receptor agonists And more.. @circaha.bsky.social buff.ly/4h45ULk www.ahajournals.org/doi/epub/10....

Mechanism of #syncope: role of ambulatory BP monitoring & CV autonomic function assessment #CardioSky #MedSky #ESC @escardio.bsky.social @victoriadelgadomd.bsky.social @jgrapsa.bsky.social @mmamas1973.bsky.social @vassv.bsky.social @gimelliale.bsky.social academic.oup.com/eurheartj/ad...

🫀 #Lipoprotein(a) is much more atherogenic than #LDL, bringing a much higher #cardiovascular risk. However, the testing demand has been low. Being linked to the individual's #genotype and not having been a target for #treatment up to now. Read more: jamanetwork.com/journals/jam...

A new ‘molecular lantern’ detects brain metastasis in mice by inserting a probe thinner than a hair into the brain "Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain" www.nature.com/articles/s41...

Humanity’s newest brain gains are most at risk from ageing The largest declines in grey matter in the brain - a sign of ageing - occurred in the frontal cortex which provides evolutionary and cognitive advantages over non-human primates. www.nature.com/articles/d41...

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

💊 #Antibiotic stewardship in patients with #sepsis is one of the use cases for #procalcitonin ( #PCT) testing. This study compares the effect and safety of guiding antibiotic #therapy with two blood #biomarkers, PCT and C-reactive protein ( #CRP). Read more: jamanetwork.com/journals/jam...

Sex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes & diabetic kidney disease: post hoc analyses of the RENAAL & IDNT trials #NephSky #CardioSky #KidneyDisease #diabetes 👇👇 link.springer.com/article/10.1...

The IL-2 SYNTHORIN molecule promotes functionally adapted Tregs in a preclinical model of type 1 diabetes insight.jci.org/articles/vie...

🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41... We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠 Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵

Hi Bluesky community! 👋 Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look! ➡️ s.embl.org/poster-bl #EMBLEvents #molecularbiology #lifesciencetraining

T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics. #Immunity "An in vitro TCR engineering platform for the creation, modification, and comprehensive profiling of TCRs that can target self-antigens." Open Access www.cell.com/immunity/ful...

🫀Point-of-care ( #POC) high sensitivity #troponin I ( #hsTnI) testing boosts Acute #Coronary Syndrome detection! This study proves its efficiency, supporting faster decisions in #emergency care. Read more: pubmed.ncbi.nlm.nih.gov/39239902/

With more layers of data, our ability to predict a person's risk of heart disease is getting better and better acpjournals.org/doi/10.7326/... [adding in social determinants of health, lifestyle, genomics, and other data] @annalsofim.bsky.social

🫀This article shows the importance of monitoring #NTproBNP and high sensitivity #troponin I ( #hsTnI) in obstructive hypertrophic cardiomyopathy. The concentrations of both #biomarkers are crucial to monitor the clinical response to therapy. European Heart Journal academic.oup.com/eurheartj/ar...

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

🧪Importance of vitamin D and its deficiency "By highlighting the biochemical pathways through which vitamin D influences calcium absorption and bone mineralization, these studies underscore its importance in maintaining strong and healthy bones." Open access pdf.ipinnovative.com/pdf/23133

‼️Tracking — and Tackling — the Recent Resurgence of Syphilis “…there was a nearly 80% increase in syphilis cases during the five years spanning 2018-2022.” www.healthcarebusinesstoday.com/resurgence-s...

Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates www.pnas.org/doi/epub/10.... @pnas.org

🩸Ensuring Transfusion Safety: Detecting Irregular Antibodies to Prevent Alloimmunization “Precision alloantibody identification complements phenotype and genotype matching to advance transfusion safety.” ashpublications.org/blood/articl...