Am I the only person who is a bit tired of hearing mitochondria are overlooked? They are very much not.

woo!

"The dream of every cell is to become two cells." - François Jacob, paraphrasing Jacques Monod.

"shouldn't have been done" -- are we really advocating for censorship in scientific biometrics now? I don't care for rankings but it really concerns me that our community increasingly talks in ways that are so polarizing.

Gorgeous science. Wowowow.

Only in biology do we a) feel bad for the absolutely richest labs in the world, and b) argue that a three year runway is unreasonable.

[1/n] Our preprint-in-progress on RNA regionalization in Stentor is no longer in progress! Now @pnas.org 🥳 Turns out a single cell isn't a homogenous soup… it has molecular geography, including things like regionalized transcription factors. Think bicoid, but in a ciliate.

Vaccines are humanity's greatest scientific achievement.

If 15-20% of labs have >20 scientists (call these "large labs"), this means ~40 percent of scientists work in "large labs"

Who chooses a conference venue in a teeny tiny town where everything closes at 8pm in hurricane season in hot Florida.

If you're a biologist, you essentially cannot use Fable 5 yet 😭

she is a major reason I was able to go to grad school. Miss you, Sue!

Molecular biologist & geneticist Susan Lindquist (b. #OTD in 1949) was a pioneer in studying protein folding. Her research demonstrated protein folding errors contribute heavily to neurodegenerative conditions like Alzheimer's & Parkinson's diseases. National Medal of Science in 2010. #WomenInSTEM

This deep sea creature is as sharp & clear as broken class, & can grow as long as your hand. This giant amphipod, (Cystisoma) only has two colored body parts: the dense orange stomach/egg pouch, & two MASSIVE eyes, which are a glittering holographic orange layer completely covering its head. 📽️ MBARI

President of MIT not mincing words today in @statnews.com www.statnews.com/2026/05/27/s...

Yes, especially so when you are a biologist for whom 90% works is an astounding success.

I'll be writing a few posts about new features in Micro-Manager. If you are interested in those, please follow @micro-manager.bsky.social.

The pearl clutching over generated references is a bit funny. Hallucinated references may be new, but the age old problem of missing citations or citations that have nothing to do with the text, self citations, or citations of friends--these are all equally harmful and prevalent and ignored problems

i shudder to think of the rather large number of times i myself have entered a citation incorrectly. pray tell me folks: how do you tell a hallucinated reference from a human mistake? i am all for minimizing AI slop, but this policy seems likely to catch as much non-AI as AI.

chromatin is related to gene expression? at the single cell level? what!

. 📷 Kristin Sundberg . #PhotoOfTheDay #Photography #BlueskyPhotography #PhotoKind

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

scientists: correlative methods do not imply causation. also scientists:

🫨. wow.

you can read about it here: www.biorxiv.org/content/10.1...

wowowowow

Currently at #TERMIS2025, sitting at an award plenary, and though the speaker has done amazing science and is a great speaker, 100% of the data she presented is 2008-2018. Why? I can read all of these papers. The point of conferences used to be to show cutting edge work.

Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we: 1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs bsky.app/profile/bior...

27 years ago, two years after the introduction of effective HIV treatment, the Bay Area Reporter, San Francisco’s lesbian and gay community newspaper, ran ‘No Obits’ as its headline. It was the first edition not to report an AIDS death in almost 15 years.

🗃️ A history mystery solved: where do potatoes come from? Nine million years ago, as the Andes were rising, a tomato cross pollinated a plant from the S. etuberosum lineage. Each plant contributed a gene, that together enabled underground stems to form tubers. www.sciencenews.org/article/pota...

huh.

What does it say if you see circles at the bottom and rectangles at the top? Asking for a friend...

@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/

BO WANG, Stanford Identifying and understanding regeneration suppressors #isscr2025

up next @tatianasg.bsky.social shared and distinct mechanisms in salamander limb and human fingertip regeneration.

ALBERT ERNESTO ALMADA Quiescent preexisting cells in skeletal muscle heal tail injuries in anole lizards 🦎 after tail amputation you see a thing called a blastema forming, muscle only starts to reappear after ~28 days of growth though. #isscr2025

Yesterday i didn't post my conference notes. Let's catch up. animal models in regeneration. MAYSSA MOKALLED washington u in st louis - approaches to spinal cord regeneration. a critical challenge in spinal cord therapies is in providing physical support for implanted neurons. #isscr2025

speechless. wow!

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.

next up masayo takahashi talking about ipsc based replacement of RPEs to cure vision loss from AMD and how to bring an experimental therapy to a trial. makes a big point that there is more to a product than just treatment. #isscr25

Michael S Pepper just gave a powerful talk about inequality in gene and cell therapy access. Africa accounts for 1/5 people on the planet. Of 2850 clinical trials worldwide, there are 5 clinical trials in the entire African continent. Entire room was silent for a couple of minutes afterwards.

Claire Booth talked at #isscr25 about gene editing therapeutics in SCID patients. Basically, we can cure many monogenic types of SCID… but we cant get them to the clinic. heartbreaking to see that the science is solid, yet the reasons for lack of advancement are regulatory.

Bing Guo just gave the coolest talk showing spleen and liver HSCs are established embryonically using a parabiosis experiment, spleen cells “remember” the spleen and can target it when transplanted into the marrow more than bone marrow derived HSCs and they respond to different stimuli. super cool

#ISSCR25 kicks off and i am listening to the cellular agriculture session. multis ceo talking now. they use ai and robotics to automate media prep and test many conditions.

#ISSCR25, here we go. Let's learn about stem cells and their differentiation properties 💪

Hey optical tech dev folks: how do you do alignment? Can you outline your alignment procedures for positioning optics and verifying their correct positioning?

first time I ever hear of freeze-thaw cycles being a good thing for RNA! Very cool!

The cellular dance that splits vessels Really appreciate this insightful commentary by Dr. Lance Munn on our recent paper @pnas.org using Microvessel-On-A-Chip to model the pillariogenesis during early #IntussusceptiveAngiogenesis 😎 pnas.org/doi/abs/10.1073/pnas.2508260122

gotta read this carefully, but at a quick glance, looks awesome