Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we: 1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs bsky.app/profile/bior...

27 years ago, two years after the introduction of effective HIV treatment, the Bay Area Reporter, San Francisco’s lesbian and gay community newspaper, ran ‘No Obits’ as its headline. It was the first edition not to report an AIDS death in almost 15 years.

🗃️ A history mystery solved: where do potatoes come from? Nine million years ago, as the Andes were rising, a tomato cross pollinated a plant from the S. etuberosum lineage. Each plant contributed a gene, that together enabled underground stems to form tubers. www.sciencenews.org/article/pota...

huh.

What does it say if you see circles at the bottom and rectangles at the top? Asking for a friend...

@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/

BO WANG, Stanford Identifying and understanding regeneration suppressors #isscr2025

up next @tatianasg.bsky.social shared and distinct mechanisms in salamander limb and human fingertip regeneration.

ALBERT ERNESTO ALMADA Quiescent preexisting cells in skeletal muscle heal tail injuries in anole lizards 🦎 after tail amputation you see a thing called a blastema forming, muscle only starts to reappear after ~28 days of growth though. #isscr2025

Yesterday i didn't post my conference notes. Let's catch up. animal models in regeneration. MAYSSA MOKALLED washington u in st louis - approaches to spinal cord regeneration. a critical challenge in spinal cord therapies is in providing physical support for implanted neurons. #isscr2025

speechless. wow!

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.

next up masayo takahashi talking about ipsc based replacement of RPEs to cure vision loss from AMD and how to bring an experimental therapy to a trial. makes a big point that there is more to a product than just treatment. #isscr25

Michael S Pepper just gave a powerful talk about inequality in gene and cell therapy access. Africa accounts for 1/5 people on the planet. Of 2850 clinical trials worldwide, there are 5 clinical trials in the entire African continent. Entire room was silent for a couple of minutes afterwards.

Claire Booth talked at #isscr25 about gene editing therapeutics in SCID patients. Basically, we can cure many monogenic types of SCID… but we cant get them to the clinic. heartbreaking to see that the science is solid, yet the reasons for lack of advancement are regulatory.

Bing Guo just gave the coolest talk showing spleen and liver HSCs are established embryonically using a parabiosis experiment, spleen cells “remember” the spleen and can target it when transplanted into the marrow more than bone marrow derived HSCs and they respond to different stimuli. super cool

#ISSCR25 kicks off and i am listening to the cellular agriculture session. multis ceo talking now. they use ai and robotics to automate media prep and test many conditions.

#ISSCR25, here we go. Let's learn about stem cells and their differentiation properties 💪

Hey optical tech dev folks: how do you do alignment? Can you outline your alignment procedures for positioning optics and verifying their correct positioning?

first time I ever hear of freeze-thaw cycles being a good thing for RNA! Very cool!

The cellular dance that splits vessels Really appreciate this insightful commentary by Dr. Lance Munn on our recent paper @pnas.org using Microvessel-On-A-Chip to model the pillariogenesis during early #IntussusceptiveAngiogenesis 😎 pnas.org/doi/abs/10.1073/pnas.2508260122

gotta read this carefully, but at a quick glance, looks awesome

Expanding Perturb-seq-like screens to multicellular systems also increases the complexity of confounding effects. We encountered this when we perturbed all TFs in mosaic embryoid bodies (EBs) and develop a scalable solution by barcoding monoclonal individuals. 🧵 www.biorxiv.org/content/10.1...

A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.

I randomly remembered a group meeting where I talked about genetic analysis. I referred to "phenotypes associated with this gene", eliciting groans from my advisor and the senior postdoc: "Genes do not have phenotypes! Alleles have phenotypes!" It cemented in me a desire for precise language.

today, I read a great paper on a signaling, non canonical role for folate in neural tube formation that made me really happy. the experiments and logic were both clear, and they used xenopus and organoid models to drive home their points. my brief write up: dangeles.github.io/blog/noncano...

Hello world! Finally got tired of twitter and decided to join this platform. my resolution for 2025 is to avoid all politics and post exclusively science related stuff. a related goal of mine is that i want to write about papers i read and ideas that come to my mind in my website!