Plasmid Society
@plasmidsociety.bsky.social
📤 223
📥 87
📝 24
reposted by
Plasmid Society
Didier Mazel
3 months ago
We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ...
academic.oup.com/mbe/article/...
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Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance
Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit
https://academic.oup.com/mbe/article/42/12/msaf311/8357255?login=true
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reposted by
Plasmid Society
PLOS Biology
3 months ago
Conjugative plasmids help spread AMR genes.
@andrewmatthews.bsky.social
@sonjalehtinen.bsky.social
&
@tatianadimitriu.bsky.social
show that
#AMR
loss in evolving populations involves streamlined
#plasmids
that gain a transmission advantage by deleting AMR genes
@plosbiology.org
🧪
plos.io/48NM0BL
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reposted by
Plasmid Society
Tatiana Dimitriu
3 months ago
Our story on plasmid streamlining is now published in PLoS Biology! With
@andrewmatthews.bsky.social
and
@sonjalehtinen.bsky.social
#MicroSky
#Mevosky
journals.plos.org/plosbiology/...
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Plasmid streamlining drives the extinction of antibiotic resistance plasmids under selection for horizontal transmission
Conjugative plasmids play an important role in the spread of antimicrobial resistance (AMR) genes among pathogenic bacteria. This study shows that AMR loss in evolving populations is associated with t...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003564
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The next (and last) session of the ISPB Virtual Seminars is coming up on 16 December Don’t miss the closing of this amazing series! ✨ Save the date!!
#Plasmid
#MGE
#ISPB
3 months ago
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🐓 Bacteria trade resistance genes in the chicken gut, but the host may influence this exchange. Small RNAs from chicken tissue modulate plasmid transfer between E. coli. 🧬
#Plasmid
#Conjugation
#miRNA
doi.org/10.1038/s442...
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Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA
https://doi.org/10.1038/s44259-025-00163-7
3 months ago
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reposted by
Plasmid Society
Nature Structural & Molecular Biology
5 months ago
New online: Structure and activation mechanism of a Lamassu phage and plasmid defense system
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Structure and activation mechanism of a Lamassu phage and plasmid defense system
Nature Structural & Molecular Biology, Published online: 14 October 2025; doi:10.1038/s41594-025-01677-4Li et al. show that a Lamassu defense system protects bacteria from phage infection by activating a lethal tetrameric DNA-cutting enzyme. In the absence of phages, a protein clamp holds the enzyme as an inactive monomer, preventing self-damage.
https://go.nature.com/3W1pMqf
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reposted by
Plasmid Society
Zamin Iqbal
5 months ago
Podcast with me and
@turiking.bsky.social
for the
@milnerevolution.bsky.social
series, on plasmid evolution over the last 100 years, talking about our (
@cazares-adr.bsky.social
, Nick Thomson,
@sarah1alexander.bsky.social
& co) recent paper
www.science.org/doi/10.1126/...
youtu.be/Mzr3TD4ijs0?...
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How the Vectors of Antibiotic Resistance Have Evolved - Professor Zamin Iqbal
YouTube video by Milner Centre for Evolution
https://youtu.be/Mzr3TD4ijs0?si=jq6x4oG4ZTNEP3YO
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reposted by
Plasmid Society
Nature Communications
5 months ago
Dissecting the fitness effects of a carbapenem resistance plasmid in clinical Enterobacterales using plasmid-wide CRISPRi screens
@aliciapcv.bsky.social
@jorgesastred.bsky.social
@sanmillan.bsky.social
@cnb-csic.bsky.social
#bacteria
#plasmids
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Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens - Nature Communications
This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the carbapenemase OXA-48 has a role in the plasmid-associated fitness costs.
https://bit.ly/42KaCJA
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reposted by
Plasmid Society
Alvaro San Millan
5 months ago
New paper with my (amazing) friend and mentor
@jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!! With
@asantoslopez.bsky.social
@wfigueroac3.bsky.social
Akshay Sabins and others
www.cell.com/cell-reports...
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Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01227-6
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The time has come for you to listen to the next session of the ISPB Virtual Seminar Series. Tuesday, October 14th, from 07:00–08:00 UTC. Two new speakers, two great new stories. Do not miss them!
#ISPB
#Plasmid
#MGEs
5 months ago
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Hey hey hey! Tomorrow, September 16th at 16:00 UTC, don’t miss the next ISPB virtual seminar! This session will focus on plasmid elimination with great speakers lined up.
#Plasmid
#ISPB
#MGEs
6 months ago
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📢 Postdoctoral research position A 2-year postdoctoral position on bacteriophages research is available at the Institut Pasteur in Paris in the Plasticity of the Genomes Unit. 🧐 Those interested can now send their applications!
7 months ago
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Must-Read Paper 👀 Check out this latest review on plasmid mobility and how interactions between MGEs shape and affect plasmid stability and transfer:
doi.org/10.1093/nar/...
#Plasmid
#MGE
#Mobility
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The extended mobility of plasmids
Abstract. Plasmids play key roles in the spreading of many traits, ranging from antibiotic resistance to varied secondary metabolism, from virulence to mut
https://doi.org/10.1093/nar/gkaf652
8 months ago
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Heads up! 📢 The 5th Session of the ISPB Virtual Seminars is tomorrow, from 8:00 to 9:00 UTC. Hope to see you there virtually!
#Plasmid
#ISPB
#VirtualSeminar
8 months ago
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Hey! Reminder ‼️ Today we’ll enjoy another session of the ISPB Virtual Seminar Series from 16:00 to 17:00 (UTC). Join us for some great science!
#Plasmids
#MGEs
#ISPB
9 months ago
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Kicking off the week with exciting news: 🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille). 💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info:
[email protected]
10 months ago
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Heey! ✋ If you missed the live session of the ISPB Virtual Seminar Series, there's still time to catch up and enjoy the great work of Zhengqing Zhou and Alicia Calvo Villamañán. Huge thanks to the speakers and the organizers!! 🫂
10 months ago
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Must-Read Paper 👀 Wrap up the week exploring how mobile genetic elements (MGEs) drive pangenome structure: Salmonella enterica serovar Typhi.
journals.asm.org/doi/full/10....
#Plasmid
#MGEs
#Salmonella
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Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome | mSystems
Given bacterial evolution occurs in both vertical and horizontal dimensions, inclusion of both core and accessory genetic material (i.e., the pangenome) is a logical step toward a more thorough unders...
https://journals.asm.org/doi/full/10.1128/msystems.00365-24?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
11 months ago
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The ISPB Virtual Seminars 2025 continue tomorrow with the second session: 📅 Tuesday, April 15 🕢 07:00–08:00 (UTC) (
everytimezone.com
) Make sure you don't miss it! 🤠
#Plasmid
#ISPBVirtualSeries
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Every Time Zone Converter
Easily find the exact time difference with the visual Time Zone Converter. Find meeting times for your contacts, locations and places around the world. Never warp your brain with time zone math again.
https://everytimezone.com
11 months ago
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Imagine resistance genes as stickers, and plasmids as the sticker albums where they're collected and swapped. 🤔🧩 Now, You should check this amazing work from Wang et al.! 👇
doi.org/10.1093/isme...
#Plasmid
#MGEs
#AntimicrobialResistance
#ARGs
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https://doi.org/10.1093/ismejo/wrad032
11 months ago
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Cigarettes: bad for your health… and for antibiotic resistance, too? 🚭🚭 Fang, Konyali and colleagues have demonstrated that smoking-derived compounds promote the conjugation rates in different environments (artificial lung sputum medium and environmental medium).
12 months ago
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Updates are back! We’ll be sharing papers and reviews relevant to our community. Please, feel free to contact us if you’d like us to feature your work. Thanks!! 🧬
12 months ago
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IT'S TODAY! IT'S TODAY! 📣 Don't miss the start of the ISPB Virtual Seminars and join the first session! ⏱️ 09:00 (GMT-7) / 17:00 (GMT+1) See you soon!
12 months ago
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The International Society for Plasmid Biology and other Mobile Genetic Elements are finally in Bluesky!! 😎😎😎
12 months ago
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