🚨The NYU Pain Research Center (PRC) and Department of Molecular Pathobiology at NYU Dentistry are seeking Assistant or Associate Professors in the fields of chronic pain mechanisms, pain therapeutics, and related disciplines. More info and apply: apply.interfolio.com/176454

📢New paper in Nature Mental Health! Dr. @karapedsgastrodoc.bsky.social is co-author on a review exploring how the gut microbiota shapes mental health through the gut–brain axis.🧠 🔗 doi.org/10.1038/s442...

Big congratulations to postdoc @sarahanajjar.bsky.social on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏 @karapedsgastrodoc.bsky.social

Cool new study showing a comprehensive map of neuroimmune interactions throughout the gut! www.pnas.org/doi/full/10....

New research highlights a stomach–brain connection in mental health. 👉 Stronger frontoparietal coupling to gastric rhythms = a marker of poorer mental health (anxiety, depression, stress, well-being). Visceral rhythms aren’t just gut feelings, they shape our emotions www.nature.com/articles/s44...

Happy Birthday to the best mentor ever, Prof. Margolis! 🥳 Thank you for always guiding and supporting us, we’re so lucky to learn from you! @karapedsgastrodoc.bsky.social

Amazing week at ANMS 2025! 🌟 Sarah, Chalystha, Lin and Kara gave fantastic talks with Chalystha winning the Frank Hamilton Travel Award and Sarah named a Young Investigator Forum Fellow. Kara’s plenary lecture was a highlight, along with meeting Nobel laureate David Julius.

New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues. @karapedsgastrodoc.bsky.social 🔗 www.nature.com/articles/s41...

Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!

@karapedsgastrodoc.bsky.social gave a fantastic talk on the lab's important work on SSRI use in the gastrointestinal tract @margolislabnyu.bsky.social highlighting @linyhung.bsky.social and @sarahanajjar.bsky.social 's work! @nyupainresearch.bsky.social

Our amazing mentor and team lead @karapedsgastrodoc.bsky.social is now officially Professor Margolis! 👏👩‍🏫 She’s the definition of supportive, visionary, and unstoppable! no one deserves it more! Feeling so lucky to be part of her team 💜 #ProfessorKara #WomenInScience #ProudTeam 💫🌟

The Fattahi Lab successfully transplanted hPSC‑derived nitrergic enteric neurons into NO‑neuron–deficient mice, restoring gut motility, and created scalable 2D/3D human ENS models to support drug discovery and cell‑therapy approaches for enteric neuropathies. www.nature.com/articles/s41...

A new study shows that food structure plays a key role in determining which gut hormones are released. @karapedsgastrodoc.bsky.social #GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege 📖 Nature Metabolism www.nature.com/articles/s42...

🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌ Game-changer for gut health. sciencedirect.com/science/arti... #guthealthmatters #WBAIL2 @karapedsgastrodoc.bsky.social

Big congrats to @linyhung.bsky.social on her Nature Reviews Journal Club piece spotlighting gut serotonin as a target for mood disorder treatment! @karapedsgastrodoc.bsky.social file:///C:/Users/Eb4415/Downloads/Hung-2025-Nature_Reviews_Gastroenterology_&_Hepatology.pdf

🎉 Big wins for the Margolis Lab at AMPIRS 2025! 👏 Chalystha and Lin rocked their talks, Taeseon and Daniel nailed their posters, and Sarah delivered an epic flash talk! 🏆 Huge congrats to Lin and Sarah for taking 1st place! So proud of this amazing team! 💜🧠 @karapedsgastrodoc.bsky.social

Titles: Maria Fernanda: Neuropilin-1 Modules nerve growth factor signaling to sustain periorbital pain Zhiting Gong: Mice lacking LRP1 in Schwann cells exhibit orofacial pain Chalystha Yie Qin Lee: Epithelial 5HT4 receptor in mood, gastrointestinal motility, and visceral pain

Happening Now! The 5th Annual Molecular Pathobiology Innovative Research Symposium is in full swing! Dazzling presentations 🎬 by the brilliant minds of Maria Fernanda, Zhiting Gong, and Chalystha Yie Qin Lee. Shoutout to Jean-Pierre N. Saint-Jeannet, PhD, for inspiring opening remarks. Stay tuned!

🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter

Shoutout to our PRC pros who rocked the Flash Talk! Titles listed below🎤mic drops all around! Sarah Najjar: Sex differences in gut serotonergic signaling of visceral pain Badr Sokrat: Compartmentalized intracellular signaling of the prostaglandin EP4 receptor contributes to pain

🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity

Lin Hung- Early Life Stress leads to dysregulated serotonin development in the gut and predisposes to intestinal pain/dysmotility later life Andres Cabezas- Structural studies of a mechanosensing ion channel in a native-like environment Emmanuel Flores- Vasopressin V2 receptor activity at lysosomes

And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride

IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells @karapedsgastrodoc.bsky.social www.pnas.org/doi/10.1073/...

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...

New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults. @vivtawfik-mdphd.bsky.social @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...

BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.

Congrats to @karapedsgastrodoc.bsky.social on becoming part of the 2025 AGA Council section leaders!! Read more👉 gastro.org/news/meet-ou...

A big shoutout to Nikhil Sharma for joining our MPB Seminar Series! 🙌 @nyupainresearch.bsky.social loved your fascinating deep dive into the enteric nervous system and its connection with peripheral sensory & autonomic ganglia. 👨‍🔬🧠✨ #Neuroscience #PainResearch #MPBSeminar

💡 A promising non-opioid strategy—SBI-810 reduces pain, opioid reward, withdrawal, and constipation through selective β-arrestin-2 signaling www.sciencedirect.com/science/arti...

In mice, gut neurons use AHR to fine-tune immune responses—suppressing defense in the ileum, enhancing it in the colon, and impacting infection clearance. 🧠🦠 #GutBrainAxis #ENS #GutImmunology @karapedsgastrodoc.bsky.social www.cell.com/cell-reports...

🎓 Huge congratulations to Dr. Andrew Del Colle!! 👏 From an outstanding Master’s student to a dedicated Research Scientist and now a freshly minted MD — we’ve been so lucky to be part of your journey in the Margolis Lab. We’re so proud of you, Andrew! 💙🧠 @karapedsgastrodoc.bsky.social

🎉 Happy (belated) birthday to the one and only @sarahanajjar.bsky.social! 🥳 She’s not just a brilliant postdoc in our lab 🧠🔬— she’s also the kindest, funniest, and most radiant person to be around 💫💛 Wishing you a year full of discoveries, laughter, and well-behaved mice! 🧪😄🐭

New study from collaborator Mark Ansorge and Ardesheer Talati published in Nature Communication shows prenatal SSRI exposure activates fear circuits in both mice and humans—revealing conserved serotonin-driven emotional development! @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...

Wonderful talk on immuno-modulatory materials from Jeff Hubbell, NYU’s new Vice President of Life Sciences and Engineering. We are excited to welcome the Hubbell Lab as our new neighbors!🧠💥🌟 @nyupainresearch.bsky.social @nyutandon.bsky.social @karapedsgastrodoc.bsky.social

🎉 Congrats to @sarahanajjar.bsky.social on her awesome Data Blitz presentation and poster, “Sex Differences in Gut Serotonergic Signaling of Visceral Pain” at the USASP meeting in Chicago! 🧠💥🌟 @karapedsgastrodoc.bsky.social @nyupainresearch.bsky.social @usasp.bsky.social

New research links fibromyalgia pain to the gut microbiome. Transplanting healthy gut bacteria reduced pain in mice—and in a small clinical trial, improved symptoms in women. @karapedsgastrodoc.bsky.social @nyupainresearch.bsky.social www.cell.com/neuron/fullt...

Amazing showing by the PRC & MPB teams at NYU’s Transforming Human Health Symposium! Big thanks to Nina Grey for hosting, plus a great fireside chat with VP of Genentech’s, Richard Bonneau & Stacy Bloom! #Innovation #HealthTech #NYUSymposium #nyuniversity #NYUDental

Fantastic day of science with this fantastic community! So proud to be @newyorkuniversity.bsky.social @margolislabnyu.bsky.social

A recent study found that Lacidophilin tablets improved IBS symptoms in rats by reducing visceral sensitivity, easing anxiety and depression, and restoring gut motility, mainly through gut microbiota regulation and inflammation control. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...

New study finds microglia-like cells in human DRGs that drive neuronal soma enlargement, axon growth, and somatosensation but are absent in mice 🪤🐁🐀 www.cell.com/cell/fulltex...

PRC PRIMED! Thank you to @rachelepol.bsky.social for presenting Nanomedicine for Pain: Towards translation through advanced materials, manufacturing and in vitro strategies! Huge round of applause 👏to @linyhung.bsky.social & @tonelloraquel.bsky.social for being amazing hosts! #PinkertonLab #RachelP

Exciting News! Researchers from the Pasca Lab at Stanford have built a functional human Pain Circuit in a Dish to model and manipulate the sensory pathway in vitro. This could lead to discovery of new analgesic drugs! #Painresearch #Neuroscience #StemCell #Organoid www.nature.com/articles/s41...

Congratulations @taeseonwoo.bsky.social from the Margolis Lab on a successful talk on the GI issues in the Angelman Syndrome mouse model @gatlinburg.bsky.social in San Diego, CA! @karapedsgastrodoc.bsky.social

New study: Boosting serotonin in the gut (not the brain) eases anxiety + depression—without the side effects. A safer path for treatment, especially during pregnancy. #GutBrainAxis #MentalHealth #SSRI @karapedsgastrodoc.bsky.social @nyupainresearch.bsky.social www.nyu.edu/about/news-p...

Awesome new paper from the Hu and Jackson labs! Piezo1 in enteric neurons controls motility, exercise response, and inflammation 🚴‍♂️🧠🦠💡#GutBrainAxis #Mechanosensation #Neurogastroenterology @karapedsgastrodoc.bsky.social www.cell.com/cell/fulltex...

New preprint from Constanza Alcaino and colleagues! Human gut organoids reveal how enterochromaffin cells sense & respond to stimuli 🧠🦠💡 #GutBrainAxis #Serotonin #Neurogastroenterology @karapedsgastrodoc.bsky.social www.biorxiv.org/content/10.1...

#itchdoctor Exciting study from the Kim Lab on how mast cells and sensory neurons drive cross-organ pain 💥🧠 #VisceralPain #NeuroImmune #IBS #ICBPS www.researchsquare.com/article/rs-6...

CONGRATULATIONS to Drs. Sarah Najjar, Lin Hung and Kara Margolis- Their review article: Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation is one of the top 10 most cited articles published in 2023! onlinelibrary.wiley.com/doi/abs/10.100… 🥳🔝🔟

This study shows that MRGPRX2-mediated mast cell activation is heightened in patients with IBS, linking this pathway to increased abdominal pain and sensory hypersensitivity. @karapedsgastrodoc.bsky.social gut.bmj.com/content/earl...