NEWS🎉 We’re excited to announce @hhmijanelia.bsky.social Investigator David Stern will join the Institute from Janelia Research Campus. His lab studies how aphids transform plants at the genetic level, uncovering secrets of #evolution & new strategies for pest control. @hhmi.org bit.ly/4np96Fb

🪱New research from the Wang Lab shows how changes in a worm’s lysosomes promoting longevity are transferred to its offspring through the epigenome, revealing how epigenetic modifications that help organisms cope with environmental stress can be inherited. 🔗 www.janelia.org/news/leaving...

🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.

🌟 Launch your own lab at Janelia 🌟 Advance our understanding of biology through theory, computational modeling & machine learning. 🔹 No teaching requirements 🔹 100% internally funded 🔹 Collaborate with expert support teams 📅 Apply by Nov. 4 👉 https://janelia.link/groupleader

We are looking for an #AIEngineer to help build protein language models that capture evolutionary constraints with @matsen.bsky.social and @jbloomlab.bsky.social at #AI@HHMI @hhmijanelia.bsky.social hhmi.wd1.myworkdayjobs.com/en-US/Extern...

🎉Congratulations to @maribyndloss.bsky.social @jenniferdoudna.bsky.social and Kim Orth—three HHMI scientists recently honored by The American Society for Microbiology @asm.org asm.org/press-releas...

🧪For more than a decade, the GENIE Project Team has collaborated with tool developers & users to take innovative biological sensors from novel prototypes to widely used laboratory staples. Now, @janeliagenie.bsky.social is unveiling their latest collaborations. www.janelia.org/news/unleash...

📢 Applications are open! Join us in May to explore computational simulation of biomechanical body models, bridging #neuroethology, #ML, physics simulation & computer vision. 🧠🤖 👁 🛏️ Lodging, meals & registration covered ➡️ Apply by Nov. 21 @ https://janelia.news/SIB26

📢 Conduct your PhD thesis research at Janelia. 🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology. 🌐 Collaborate across disciplines 🛠️ Work with tool builders 🤝 Train in a supportive environment ➡️ janelia.org/graduate

Out now in @Nature.Com: Researchers from @UCSDMedSchool.bsky.social develop engineered proteins to selectively reduce #cocaine-seeking behavior without affecting natural rewards. This innovative method may lead to new gene therapies for cocaine #addiction buff.ly/2LEPha8

🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools. 🔗 royalsociety.org/medals-and-p...

LOCL-TL allows researchers to study which proteins are being made, or translated, at specific locations within the cell. @jswlab.bsky.social developed this tool and used it to characterize translation happening at the mitochondria. wi.mit.edu/news/locally... @hhmi.org

🧪 New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave & change as an organism develops, information that could help scientists better understand the formation & function of synapses.➡️ https://hhmi.news/4mFMhMY

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

Please join us in congratulating HHMI Investigators Jennifer Doudna (@jenniferdoudna.bsky.social) and David R. Liu, recipients of national awards from the American Chemical Society (@acs.org) for 2026.‬‬ 🔗 cen.acs.org/people/award...

Congratulations 2025 Gilliam Fellows and Advisors! 🎉 The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors.

New findings show low-oxygen air reverses Parkinson’s symptoms in mouse model, suggesting possible new way to treat this neurodegenerative disorder: a pill that mimics low oxygen.

HHMI Chief of Strategic Initiatives Bodo Stern writes in the LSE Impact of Social Sciences Blog about Nature's recent decision to publish peer review reports. "True transparency in peer review must begin at the outset," he writes, "not as an afterthought to editorial gatekeeping."

🚨 Attention early-career scientists! 🚨 Become a Theory Fellow at Janelia and use computation & theory to tackle biological problems. ✅ Three-year appointment ✅ Collaboration across scientific disciplines ✅ Dynamic research environment

🪰 A new ‘Eyemap’ developed by a team led by Arthur Zhao & @michaelreiser.bsky.social reveals how visual information detected by the fly’s eye shows up in neurons deep in the brain. Remarkably, the eye’s shape determines how flies see motion.👁️ 🔗 hhmi.news/4kSZjou

🌿 How do plants defend themselves against microbial invaders? HHMI Hanna Gray Fellow @kcox-bioguy.bsky.social is working to uncover the cellular-level interactions that shape plant immunity.

Partnership between David Liu, @jacksonlab.bsky.social, and rare disease group RARE Hope leads to first use of prime editing for a brain disease that reduced symptoms, extended lifespan in mice, offering hope for other rare genetic diseases. #Science #PrimeEditing

Igor Siwanowicz created these images of the underside of the front foot of a male diving beetle. You can see suction cups that are used during mating, as well as a broad plate and exterior spines that aid in swimming.

Meet Kyndall Nicholas, an HHMI Gilliam Fellow at the University of Pennsylvania (@upenn.edu). She studies how our everyday diet can build resilience against traumatic brain injury, asking what we can eat daily to help protect our brains.

Our paper describing how in-host evolution of a recently emerged, highly pathogenic coronavirus modulates entry into cells, membrane fusion and likely pathogenicity has now been published in its peer-reviewed form! Led by Ale Tortorici! @hhmi.org www.nature.com/articles/s41...

Andy Moore at @hhmijanelia.bsky.social created this image to visualize the organization of microtubules in several adjacent cells. Like a spider web, cells use a network of molecular “highways” called microtubules to move cellular and molecular components around.

A new class of simplified computational models developed by @hhmijanelia.bsky.social researchers could help shed light on how we see. Read more: hhmi.news/3Gs5aDa 👀

🧠 How does your brain mature over time? HHMI Freeman Hrabowski Scholar HaoSheng Sun is exploring the genetic timing mechanisms that guide the maturation of the nervous system.

ATTN: students & postdocs in #theoreticalneuroscience! Applications are now open for @hhmijanelia.bsky.social's "by the students, for the students" #neurotheory workshop, which will take place Nov. 9 - 14, 2025.

🧠Zoning out could be beneficial—and may actually help us learn faster. 🥼New research led by @zhong-lin.bsky.social @marius10p.bsky.social @computingnature.bsky.social 🔗 www.janelia.org/news/zoning-...

🚶Aimlessly wandering around a city or exploring the new mall may seem unproductive, but new research led by @zh0ng0.bsky.social @marius10p.bsky.social @computingnature.bsky.social suggests it could play an important role in how our brains learn.‬‬ 🧠 🔗 www.janelia.org/news/zoning-...

In this video you can see a visual map of some of the neurons within a fruit fly’s ventral nerve cord (VNC), like that of a human’s spinal cord. Neurons progressively stack on top of each other and at the end of the video, you can see a rough neuronal map of the VNC.

“Basic scientific research is so appealing to me because, despite it being very frustrating and a lot of work, the payout is so amazing,” explains @fsantoriello.bsky.social‬, a postdoctoral researcher in HHMI Investigator Bonnie Bassler’s lab at Princeton.

Congrats to HHMI Freeman Hrabowski Scholars @channyskye.bsky.social , Josefina del Mármol (@delmarmollab.bsky.social), @yvetteefisher.bsky.social and Theanne Griffith (@doctheagrif.bsky.social), named 2025 McKnight Scholars for their demonstrated commitment to neuroscience & mentoring others! 🌟

This fiery mixture of red and green neurons in the brain of a mouse shows how interconnected different types of neurons can be. Shown in green are the excitatory pyramidal neurons, and in red are inhibitory interneurons. Credit: Nelson Spruston and Erik Bloss, @hhmijanelia.bsky.social

A new method developed by researchers at @hhmijanelia.bsky.social enables scientists to surpass the resolution limit of fluorescence microscopy. Read more: hhmi.news/444HufZ

HHMI Tangled Bank Studios brings science to life through powerful, visually stunning storytelling.✨ For over a decade, @tangledbankhhmi.bsky.social‬ has delivered award-winning films that engage audiences with the wonder, complexity, and importance of science.

Researchers at @hhmijanelia.bsky.social are decoding how neurons carry out computations carefully calibrated to an animal’s movement and environment to precisely regulate the release of neuromodulators—chemicals that fine-tune brain activity and enable us to adapt to new situations.

How does basic science explain bacteria’s big impact? At Princeton, HHMI Investigator Bonnie Bassler and her lab are leading research in quorum sensing, the process by which bacteria communicate with one another to carry out collective tasks. Watch and find out more about their work.

How do immune cells sense pathogen-triggered changes in fatty acid synthesis—and use that info to limit inflammation? At @uwmedicine.bsky.social, HHMI Hanna Gray Fellow Autumn York is uncovering the molecular links between metabolism and immune response. #HannaGrayFellows

🥼Researchers, led by @mishaahrens.bsky.social, Ziqiang Wei & Takashi Kawashima, are decoding how neurons carry out computations carefully calibrated to an animal’s movement & environment to precisely regulate the release of neuromodulators. www.janelia.org/news/new-res...

Andy Moore at ‪@hhmijanelia.bsky.social‬ created this time-lapse video that shows the dynamic structure of the endoplasmic reticulum (ER) within a kidney cell.

Meet Gilliam Fellow Joyah Watkins! 👋

Meet our HHMI summer interns! ☀️ This incredible group is spending the summer learning and contributing across a range of departments—including communications, conference services, talent management and organizational development, hospitality, legal, and more. We’re thrilled to have them on board!

Andy Moore @hhmijanelia.bsky.social created this video showing a cytoskeletal mechanism called an actin wave in a so-called HeLa cell. In orange are the actin filaments and in blue are the mitochondria, some of which appear to move with or be shifted by the active wave.

ICYMI: Sweet news from HHMI Investigator Charles Zuker and his team at Columbia University, who mapped the structure of the sweet receptor in our taste buds. Their work could one day enable the food industry to create sweet foods using less sugar without sacrificing flavor. → hhmi.news/3F0plr4

Why don’t some probiotics supplements do much for our gut health? To help answer this, HHMI Hanna Gray Fellow Guillaume Urtecho is studying the genes and enzymes that help bacteria thrive in the gut—insights that could benefit human health.

The spore, the merrier. 🌿 This image shows a cross section through the reproductive region of a fern (Ceratopteris richardii), revealing its intricate internal structures. The blue and purple ovals are spores, which ferns use to reproduce and spread.

Geoffrey Meissner and the FlyLight Team at @hhmijanelia.bsky.social created this video which shows a progressive rainbow of neurons in the brain of a fruit fly – but this is just a small sampling of the more than 135,000 neurons in a typical fruit fly’s brain.

A new #openscience fruit fly resource from @hhmijanelia.bsky.social reveals nerve circuits that control flight and courtship. Read more here: hhmi.news/3H3ohn8