Rewiring natural killer cells for next-generation cancer therapies

At today’s #CAPIT Bioinformatics & Computational Biology WG meeting, Dr. Chi Zhang of University of Nebraska - Lincoln presented his work on AI-powered image feature extraction and data synthesis in pancreatic cancer.

The latest CAP-IT Newsletter is out! It features highlights and reports from the July 2025 CAP-IT Summit, along with updates on network progress: indd.adobe.com/view/32541c2...

New Tools and Resources from the NCI Data Sharing Hub , now added to the CAP-IT Shared Resources Catalog. Check it out and all NCI/NIH Shared resources at the link below: ncicapit.org/en/resources...

The amazing @ptorresayuso.bsky.social from #FoxChaseCancerCenter and #TempleUniversity presenting his exciting research at the @ncicapit.bsky.social summit

The 2025 Annual @ncicapit.bsky.social Summit is #Outofthisworld good!!! The plenary speaker #EvaSzabo, the keynote presentation by #RafiAhmed followed by AI guru #ChanghueiYang & #force ‘s #SueFredman & panelist for #EmergingTechnologies lead by the amazing #ShannonHughes were extraordinary!!!

Don't wait - register now for the CAP-IT Virtual Annual Summit on July 24, 2025! Open to the public with exciting talks on cancer prevention and interception. 🔗 Register: tinyurl.run/M3wsBV ℹ️ Info: ncicapit.org 📧 [email protected] #CancerPrevention #NCICAPIT

A personalized neoantigen vaccine + Montanide/poly-ICLC/ipilimumab reshapes the T cell landscape in melanoma patients: - Strong CD8+ responses - TCR repertoires expanded beyond anti–PD-1 - Vaccine-specific TILs identified post-treatment www.cell.com/cell/abstrac...? #Neoantigen #Melanoma #Tcells

We have a great lineup of events this summer, we hope you can join us!

New in @cellcellpress.bsky.social : Exercise boosts immune checkpoint inhibitor (ICI) efficacy in #Melanoma via microbiota-derived formate, which enhances CD8⁺ T cell immunity through Nrf2 activation. cell.com/cell/abstrac... #Immunotherapy #Microbiome #CancerResearch

Now online!

New in @thelancet.com : A comprehensive review on cancer vaccines and their role in shaping the future of immunotherapy. Read here: www.thelancet.com/journals/lan...

New @thelancet.com - Retifanlimab with carboplatin and paclitaxel for locally recurrent or metastatic squamous cell carcinoma of the anal canal (POD1UM-303/InterAACT-2): a global, phase 3 randomised controlled trial www.thelancet.com/journals/lan... #GastroSky #MedSky #OncSky

New study in Cell: HIF upregulates endogenous retroviruses in clear cell kidney cancer, generating tumor-specific antigens. ERV-targeting T cells show promise for immunotherapy and HIF stabilizers may unlock similar responses in other tumors. #CAPITPublication pubmed.ncbi.nlm.nih.gov/40023154/

We’re excited to announce that the CAP-IT Virtual Annual Summit will be held on July 24, 2025! Register here: docs.google.com/forms/d/e/1F... For more information, visit : ncicapit.org or email: [email protected] #CancerPrevention #NCICAPIT

REVIEW 🚨 Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development + clinical translation continue to face challenges. Here, Zaidi, Jaffee & Yarchoan summarize this & highlight advances in the field. 📖 👇

NEW content online!

Small-molecule RNA therapeutics to target prostate cancer

Translation dysregulation in cancer as a source for targetable antigens

Online Now: Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

🚨 The 2025 #CAPITSummit is coming! 🗓️ Agenda is live & public registration is now open! 🔗 Explore the program & sign up today via the CAP-IT web portal: ncicapit.org/en/cap-it-su...

May is Brain Tumor Awareness Month. Here's what you should know about the brain and brain tumors.

We’re excited to announce that the CAP-IT Virtual Annual Summit will be held on July 24, 2025! Register here by May 16, 2025: docs.google.com/forms/d/e/1F... For more information please visit : NCICAPIT.org or email: [email protected] #CancerPrevention #NCICAPIT

🚨 New #JITC article: Researchers uncover frameshift-derived neopeptides in Lynch syndrome—opening doors to innovative cancer prevention strategies. 🔬 Read more: bit.ly/3EiJBUN

Sometimes cancer returns years after treatment—often having spread. Researchers suspect dormant cancer cells and their interactions with the immune system play a key role in when and how this happens. www.cancer.gov/news-events/...

Colon cancer is on the rise around the world. This new report concludes that early-life exposure to gut bacteria that produces colibactin, which is mutagenic, may be contributing www.nature.com/articles/s41...

Data demonstrated that MyD88 acts downstream of the T-cell receptor to regulate T cell fate implying a molecular mechanism for #MyD88 in T cell biology that could be targeted to fine-tune T cell effector function and survival therapeutically. Read more: ow.ly/yPEs50VGr17

📢ONLINE @naturegenet.bsky.social 📰Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring. By Wenbao Yu, Kai Tan and colleagues. ⬇️ www.nature.com/articles/s41...

A new treatment approach for advanced-stage Hodgkin lymphoma is showing promising results. “This treatment appears to be more effective and less toxic — and really sets a new standard,” says Margaret Shipp, MD. Learn more: bit.ly/4cBH98f

The Lancet @thelancet.bsky.social: Pancreatic cancer—closely tied to smoking, obesity, and diabetes—is projected to become the 2nd leading cause of cancer death by 2030. A new Seminar outlines urgent needs for novel therapies and research priorities: hubs.li/Q03hN4Hj0

Over 90% of people who had their stomach surgically removed to prevent cancer reported at least one chronic complication two years later—some life-altering. More in this recent NIH study: go.nih.gov/mHLjnil

Can prevention and early detection significantly reduce the burden of cancer? The AACR and its members have long focused on finding better ways to detect cancer in its earliest stages—or preventing malignancies from developing altogether. www.aacr.org/about-the-aa...

If you want to understand how cells function, you have to work out what proteins interact with — and where https://go.nature.com/4hYLaol

Regulation of #endocrine #tumours by aberrant #GPCRs is not restricted to #cortisol-secreting #adrenal lesions, but also occurs in tumours of several other organs www.thelancet.com/journals/lan... #pituitary #thyroid #neuroendocrine #PPGLs primary #aldosteronism #MedSky #EndoSky #OncSky

A new spatial transcriptomics approach eliminates the need for time-intensive imaging with specialized equipment, making the technique accessible to more researchers around the world. @naturebiotech.bsky.social

Join NCI's Office of Data Sharing (ODS) webinar series to learn about tools, resources, and initiatives enabling effective data management, sharing, and access. 📅 April 9: Summary & feedback from the "Enhancing Data Reuse in Cancer Research" workshops. Register now 👉 shorturl.at/aj7IR

Newly published review in @cp-cancercell.bsky.social: Neoadjuvant immune checkpoint therapy: Enabling insights into fundamental human immunology and clinical benefit dlvr.it/TJkD7k

Funding opportunity from NCI’s Center for Global Health: “Dissemination and Implementation Science for Cancer Prevention and Control in Low Resource Environments.” Learn more: go.nih.gov/G9152eA #ImplementationResearch #NCIGlobal

#Comment🚨 Scott Weichenthal @mcgill.ca#Commenthighlights that wildfires emit carcinogenic pollutants, raising long-term cancer risks in affected populations and outlines actionable solutions to reduce exposure and mitigate risks. 👀 ⬇️

What is the threshold of alcohol intake that poses health risk? A new feature @nature.com www.nature.com/articles/d41... open-access

Unconventional T cells (iNKT, γδ T, and MAIT cells) bridge innate and adaptive immunity, rapidly responding to tumors and shaping the TME. Recent insights into their biology and novel therapies highlight their potential in cancer immunotherapy. www.cell.com/cancer-cell/...

Single Cell RNA Sequencing Analysis of Human Melanoma Reveals A Distinct Prognostic Myeloid Cell https://www.biorxiv.org/content/10.1101/2025.03.05.633739v1

The review in @thelancet.bsky.social reflects on 20 years of clinical and translational insights drawn from B-cell targeted therapies for adult autoimmune rheumatic diseases, and highlights how these therapies have informed an exciting new era of future therapeutic developments. hubs.li/Q03b6D7y0

'New insights into the noncanonical inflammasome point to caspase-4 as a druggable target' Progress article by Elad Elkayam, Francois Gervais, Hao Wu, Michael Crackower & Judy Lieberman @harvardmed.bsky.social @bostonchildrens.bsky.social #inflammasome #immunology #immunosky

Single-cell RNA sequencing of immune cells for over 1,000 people age 18-97 years. A clock of our immune system aging. Tells us about an individual's response to infection, vaccination, Long Covid. Towards an immunome. www.nature.com/articles/s43...

While progress has been made in treating #NSCLC, patients would further benefit from earlier detection & effective interception. Here, Spira and colleagues explore advances in identifying premalignant lesions, and devise approaches for stratification + interventions. https://bit.ly/3QE86...

Research led by Dr. Kayvan Keshari, a biochemist and bioengineer at MSK, found that immune cells might be reprogrammed to use the body’s #fructose — a naturally occurring sugar — as an energy source that supercharges them to fight #cancer.