loading . . . The global epidemiology of acute myeloid leukaemia Nature Reviews Clinical Oncology, Published online: 05 December 2025; doi:10.1038/s41571-025-01099-7Despite the availability of various novel therapies, the global incidence of acute myeloid leukaemia (AML) has continued to increase. Owing to a combination of population ageing and more effective diagnosis, AML remains much more common in economically developed countries. Conversely, AML is less common in the economically developing world, albeit often with worse outcomes owing to a lack of access to effective therapies. In this Review, the authors describe these global trends as well as their underlying reasons, including the changing landscape of risk factors, demographic disparities and differing treatment outcomes. https://www.nature.com/articles/s41571-025-01099-7?utm_source=dlvr.it&utm_medium=social&utm_campaign=nrclinonc