Nature Reviews Clinical Oncology (@natrevclinonc.nature.com)

Novel colorectal cancer screening methods — opportunities and challenges Nature Reviews Clinical Oncology, Published online: 06 June 2025; doi:10.1038/s41571-025-01037-7Despite being the second most lethal and the third most prevalent form of cancer, most cases of colorectal cancer (CRC) can be either detected at an early stage or prevented using screening colonoscopy with removal of precursor lesions. Nonetheless, universal colonoscopy is expensive and time consuming, and can be unpopular. Other less-invasive screening tests involving either faeces or more recently blood samples have the potential to improve overall CRC screening uptake and are an active area of research and development. In this Review, the authors describe the clinical utility of novel CRC screening methods such as multitarget stool DNA tests and blood cell-free DNA tests, including both the challenges and opportunities arising from their implementation. https://www.nature.com/articles/s41571-025-01037-7?utm_source=dlvr.it&utm_medium=social&utm_campaign=nrclinonc