Die #Hyperthyreose und andere Formen der #Thyreotoxikose sind relativ häufige endokrine Erkrankungen, die mit einer hohen Letalität einhergehen und oft zu spät erkannt werden. Das folgende #Skytorial soll eine kurze Einführung in das klinische Management der Thyreotoxikose geben. 🧪 🩺 #MedSky

Médicaments anti-obésité : comment Eli Lilly a détrôné le géant Novo Nordisk www.lexpress.fr/economie/med...

Der Ex-EU-Abgeordnete Nathan Gill hat gestanden, dass er von Russland bestochen wurde - für Geld machte er im EU-Parlament prorussische Erklärungen. Gill war zeitweise Vorsitzender der extrem rechten "Reform" in Wales. Denkt daran, wenn Rechte nächstes Mal Russland unterstützen.

#FFT (Fast Fourier Transform), the (allegedly) most important algorithm of all time was invented during a boring meeting: youtu.be/nmgFG7PUHfo?...

Mathematical modelling of #insulin-#glucose #homeostasis delivers new and improved methods for metabolic endotyping. #prediabetes #diabetes #metabolic_syndrome #betacell pubmed.ncbi.nlm.nih.gov/36271244/ doi.org/10.1038/s415...

Gestational #diabetes mellitus (GDM) is linked to significant adverse outcomes for both mothers and their offspring. Since #SPINA-GBeta outperforms #HOMA-Beta, its use is advised as a preferred calculated #biomarker for the evolution and pathophysiology of #GDM. pubmed.ncbi.nlm.nih.gov/40943638/

An early analog computer: The simple machine that visualised atomic orbitals www.chemistryworld.com/opinion/the-...

Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics

My latest cartoon for @newscientist.com

Würde man diesen Test zur Voraussetzung dafür machen, dass man wählen darf, läge die AfD unter 10 Prozent www.bamf.de/SharedDocs/A...

TW Gewaltschilderung im mittleren Abschnitt

There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis. pubmed.ncbi.nlm.nih.gov/39290156/

Einladung zur 3. Endokrinologischen Abendsprechstunde: Up-to-date Schilddrüse 2025 Von der #Kinderendokrinologie über #Schilddrüse und #Nebenschilddrüse bis zur Arbeit einer Selbsthilfegruppe in der #Endokrinologie www.sci.events/e_180/uptoda... 🧪 🩺 #MedSky

🆕Removing barriers to vital thyroid hormone (L-T3) could improve outcomes🆕 A new blog by Mary Saunders, a patient with hypothyroidism, featured on the hub today. pslhub.org/learn/commis... @mary-saunders.bsky.social @thyroiduk.bsky.social

Please share my post if you would like to see better hypothyroid care for patients. We need prompt, accurate diagnosis and appropriate treatment, including access to liothyronine, T3 for those who need it. Or send your own story to Patient Safety Learning

Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study. pubmed.ncbi.nlm.nih.gov/40579157/ doi.org/10.1210/clin...

"Photographers asked me to unbutton my blouse lower, whilst journalists wanted to know my vital statistics and whether I was taller than Princess Margaret.”

„Patienten mit COVID-19 wiesen ein erhöhtes Risiko für Schilddrüsenkrebs auf... Diese Ergebnisse deuten auf einen möglichen Zusammenhang zwischen SARS-CoV-2 und der Entstehung von Schilddrüsenkrebs hin, was weitere prospektive Untersuchungen erforderlich macht.“ www.mdpi.com/2227-9059/13...

Freue mich über meine geheime Wahl in die #Leibniz-Sozietät der Wissenschaften zu Berlin. Mehr Infos: news.rub.de/leute/2025-0...

#Syndrome_T, i.e. persistent symptoms and reduced #QoL despite normal #TSH concentration, affects 10% of #hypothyroid patients on #levothyroxine. Careful, multimodal and personalised treatment can result in significantly improved outcomes. #hypothyroidism #thyroid #SORSHOT doi.org/10.1007/978-...

Man wird nicht zum Genie, weil man einer Maschine beim Schreiben, Zeichnen und Entwerfen zuschaut – man wird passiv. Was die ganzen KI–Jünger verpassen, vielleicht, weil KI wie eine Party-Droge wirkt: Gehirne sind wie künstliche Intelligenz, wenn sie nicht trainiert werden, entwickeln sie sich nicht

SPINA apps are also available from European servers, provided by #CERN's #zenodo: doi.org/10.5281/zeno... doi.org/10.5281/zeno... ‪@cern.bsky.social‬

#SPINA_Thyr and #SPINA_Carb, two implementations of the structure parameter inference approach (SPINA), provide evidence-based improved methods for diagnosis and endotyping of endocrine diseases. Now, thoroughly tested apps for Mac and Windows are available for free download. spina.sf.net

Signifikanter Anstieg von Hüftkopfnekrosen nach COVID-19 Die Osteonekrose des Femurkopfes (ONFH, Hüftkopfnekrose) ist eine häufige Erkrankung bei Hüftoperationen, die durch das Absterben von Knochenzellen aufgrund einer Unterbrechung der Blutversorgung und letztendlich durch eine irreversible …

For the diagnosis and management of #hypothyroidism, measuring #TSH (thyrotropin) concentration is necessary, but it isn’t sufficient. Additional #biomarkers help to improve diagnostic power and to identify #endotypes of dysregulation. doi.org/10.1007/978-... 🧪 🩺 #MedSky

These four apps are part of the movement of endocrine cybernetics, an approach that revolutionises our understanding of hormonal systems and the management and diagnosis of associated diseases. And all four apps are written in #Object_Pascal. #Pascal #programming

SPINA Carb 5.1.0 Cyclone has been released in its final version. #SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Die thyreotoxische Krise hat noch immer eine unnötig schlechte Prognose, weil sie zu spät erkannt und behandelt wird. Die Berücksichtigung der komplexen Pathophysiologie kann Leben retten. #Schilddrüse #endokrine_Notfälle #MedSky 🧪 🩺 pubmed.ncbi.nlm.nih.gov/22878518/ dx.doi.org/10.1007/s000...

Measles vaccines save millions of lives each year

Complex regional pain syndrome (CRPS) goes along with secondary #hyperparathyroidism. Our group was the first to describe this. The mechanism leading to #sHPT is unclear, but it may contribute to the loss of bone substance in #CRPS. pubmed.ncbi.nlm.nih.gov/30747906/ doi.org/10.1097/j.pa...

The first article of the modern German constitution is an absolute banger. The first five words alone are a wonderful guide for all future policies. What this looks like in practice is often challenging but I for one LOVE that principle.

The interaction of three hormones, #TSH, #T4 and #T3, lays the foundation for #thyroid #homeostasis and its #allostatic responses. It is necessary to forgo a univariable sight and to consider the evolution of the multihormonal working point to understand health and disease. doi.org/10.1007/978-...

Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno... #SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA

I am privileged to announce the publication of the Anti-Autocracy Handbook: sks.to/autocracy 1/12

I just dropped a short video exploring green coding and whether Free Pascal could be part of the solution. Could Pascal help us write cleaner, more energy-efficient software? youtu.be/JRZ_CI5lzFY Keen to hear what you think... #GreenCoding #FreePascal #EcoTech #SustainableSoftware #CodingForGood

The brain's master conductor role in our aging process New feature @nature.com by @dianakwon.bsky.social www.nature.com/articles/d41...

Multiple feedforward motifs and feedback loops maintain #thyroid #homeostasis and #allostasis. The mechanism of relational stability maintains T3 in a balanced and safe range, even in conditions of declining thyroid function. doi.org/10.1007/978-... 🧪 🩺 #MedSky

In patients undergoing #thyroid surgery due to nodules, #SPINA-GT is lower (and the set point of the homeostatic system higher) in cases of thyroid cancer compared to benign nodules. doi.org/10.3389/fend...

Signalling via #thyroid hormones is more than T3 and T4. It involves 27 molecules based on the thyronine skeleton, 10 transmembrane transporters, 3 deiodinases, 6 receptors, and 4 types of action, unfolding a complex firework of possibilities, explaining health and disease. doi.org/10.1007/978-...

"The finding of statistical significance is perhaps the least important attribute of a good experiment...." David Lykken (1968). Statistical significance in psychological research. Psychological Bulletin. doi.org/10.1037/h002...

If a screening test that is done over consecutive years has a false positive rate of 10%, by occasion 7 the prob of a false + is 0.522, therefore prep pts to ‘expect a false +’ Maths lesson at #bcs2025 by the superb @kityates.bsky.social #cardiosky #medsky

Putin-Logik: Zivilisten bombardieren hilft dem Frieden, aber russische Waffen zerstören, damit das nicht mehr geht, ist Kriegstreiberei.

Relational stability is a major motif of the intertwined feedback loops of #thyroid #homeostasis. The integrated systemic roles and interdependent homeostatically regulated equilibrium of TSH, FT4 and #deiodinase​s maintains appropriate FT3 concentrations. doi.org/10.1007/978-... 🧪 🩺 #MedSky

Computer simulations with #SimThyr enhance our understanding of the physiology of hypothalamic-pituitary-thyroid feedback control. This applies, for example, to the evolution of #TACITUS syndrome. #thyroid #hypothyroidism #NTIS #biocybernetics doi.org/10.1007/978-...