Gastroenterology Advisor
@gastroadvisor.bsky.social
📤 14
📥 4
📝 68
Trusted knowledge base of practical information and resources focused on gastroenterology medicine.
The presence of
#GERD
is associated with an increased incidence of
#pulmonary
diseases, but this effect may be attenuated with GERD treatment. Read More:
https://bit.ly/4nPG0Ow
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GERD Linked to Increased Incidence of Pulmonary Disease
GERD is linked to an increased incidence of pulmonary diseases, but GERD treatment may attenuate the effect.
https://bit.ly/4nPG0Ow
about 3 hours ago
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0
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#Diabetes
risk factors were identified in 64.6% of adults and 35.0% of children in households of adults with prediabetes. Read More:
https://bit.ly/47OFH0j
1 day ago
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@PharmaTher, which produces the recently approved
#ketamine
product for surgical pain management,
#KETARx
, intends to expand therapeutic ketamine use to treat depression, neurological disorders, and rare or chronic pain conditions. Read More:
https://bit.ly/4nQlVaI
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FDA Approves Ketamine Product, KETARx, for Surgical Pain Management
The ketamine product KETARx produced by PharmaTher has been approved by the FDA for use in surgical pain management.
https://bit.ly/4nQlVaI
3 days ago
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#Semaglutide
treatment was associated with a significantly increased risk of nonarteritic anterior ischemic optic neuropathy but not eye disorders or diabetic retinopathy. Read More:
https://bit.ly/43pXwS9
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Semaglutide Not Linked to Increased Risk for Eye Disorders, Diabetic Retinopathy
Semaglutide was not linked to eye disorders or retinopathy, but it was associated with a higher risk for NAION.
https://bit.ly/43pXwS9
4 days ago
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0
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Saliva
#insulin
levels were highest in the '3obese group and elevated in the overweight group compared with the normal weight group, despite the lack of significant difference in fasting and post-meal glucose levels. Read More:
https://bit.ly/3LGJHIS
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Saliva Insulin Can Differentiate Hyperinsulinemia in Normoglycemic People
Saliva insulin levels were indicative of differences between normal and hyperinsulinemic responses in normoglycemic individuals.
https://bit.ly/3LGJHIS
5 days ago
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0
0
Various factors may increase risk for microscopic
#colitis
—
#NSAIDs
among them. Read More:
https://bit.ly/3Xo6qfk
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Risk Factors for Microscopic Colitis Identified: NSAIDs, Statins, PPIs, Smoking
Individuals who received treatment with NSAIDs and statins had an increased risk for microscopic colitis.
https://bit.ly/3Xo6qfk
6 days ago
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0
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The Gut Microbiome’s Role in Women’s Reproductive Health Read More:
https://bit.ly/47XA409
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The Gut Microbiome’s Role in Women’s Reproductive Health
Evidence links the gut microbiota and fertility to women’s reproductive health, influencing hormone metabolism, and conditions such as PCOS.
https://bit.ly/47XA409
6 days ago
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Serious infections requiring hospitalization are independently associated with a significantly increased risk for death among those with
#CLD
. Read More:
https://bit.ly/4o1gUg2
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Serious Infections Associated With Increased Mortality in Chronic Liver Disease
Serious infections significantly increase the mortality risk among adults with chronic liver disease, including those without cirrhosis.
https://bit.ly/4o1gUg2
8 days ago
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Patients with overweight and
#obesity
undergoing simultaneous colon and liver resection for
#CRLM
have an increased risk for in-hospital complications, especially acute
#kidney
injury. Read More:
https://bit.ly/42ulVFP
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Obesity Affects Outcomes of Colon and Liver Resections in Colorectal Liver Metastasis
Obesity and overweight are linked to increased risk for complications among individuals undergoing simultaneous liver resection for CRLM.
https://bit.ly/42ulVFP
9 days ago
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High adherence to the
#Mediterranean
diet was associated with a reduced risk of developing systemic
#lupus
erythematosus. Read More:
https://bit.ly/42sIcUi
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Adherence to the Mediterranean Diet May Lower the Risk for SLE
High adherence to the Mediterranean diet is associated with a reduced risk for SLE, with the relationship partially mediated by certain liver and kidney function biomarkers.
https://bit.ly/42sIcUi
10 days ago
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1
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#Canagliflozin
is associated with a clinically meaningful reduction in
#HbA1c
for children and adolescents with
#T2DM
. Read More:
https://bit.ly/3KBT8sI
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Canagliflozin Tied to Reduction in HbA1c in Children, Adolescents With T2D
A greater proportion of participants achieved HbA1c levels below 6.5% with canagliflozin than with placebo.
https://bit.ly/3KBT8sI
11 days ago
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Faster resolution of gastrointestinal symptoms, faster clearance of spike antigen, and faster return to usual activities were reported for children treated with
#larazotide
. Read More:
https://bit.ly/4mRWdCa
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Larazotide May Speed Recovery in Children With Multisystem Inflammatory Syndrome
Larazotide speeds resolution of gastrointestinal symptoms and clearance of spike antigen in multisystem inflammatory syndrome in children.
https://bit.ly/4mRWdCa
12 days ago
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1
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Approximately 43% of patients with
#IBD
are physically inactive due to factors like disease activity,
#fatigue
, and
#smoking
. Read More:
https://bit.ly/46GyEaW
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High Rates of Physical Inactivity Common Among Adults With IBD
Nearly half of individuals with IBD are physically inactive, with disease activity, fatigue, and smoking linked to lower activity levels.
https://bit.ly/46GyEaW
13 days ago
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#Psychological
support is important for managing
#ulcerative
#colitis
and for helping to achieve remission.
#UC
Read More:
https://bit.ly/4pT0R5H
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Early Mental Health Improvement Predicts Long-Term Remission in UC
Early improvement in mental health symptoms among individuals with ulcerative colitis is associated with a higher likelihood of disease remission.
https://bit.ly/4pT0R5H
13 days ago
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1
1
Overall, 56% of patients with abnormal blood test results received a follow-up
#colonoscopy
. Read More:
https://bit.ly/48XLe6S
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Follow-Up on Blood-Based Colorectal Cancer Screening Results Is Low
Just under half of patients who received an abnormal blood test had a follow-up colonoscopy in the short term.
https://bit.ly/48XLe6S
14 days ago
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Increases in the prevalence of disorders of the gut-brain interaction were seen within the
#esophageal
,
#gastroduodenal
, and
#bowel
domains following the
#pandemic
. Read More:
https://bit.ly/433Y0x1
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Prevalence of Disorders of Gut-Brain Interaction Increased After Pandemic
Large postpandemic prevalence increases were seen in functional dyspepsia and irritable bowel syndrome among other DGBIs.
https://bit.ly/433Y0x1
15 days ago
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The use of any
#GLP
-1 RA, but particularly
#semaglutide
and
#liraglutide
, was associated with an increased risk for nonarteritic anterior ischemic optic neuropathy compared with other second-line antidiabetic medications. Read More:
https://bit.ly/4mW221r
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GLP-1 Receptor Agonist Use Linked to Nonarteritic Anterior Ischemic Optic Neuropathy
GLP-1 receptor agonist use was associated with an increased risk for nonarteritic anterior ischemic optic neuropathy.
https://bit.ly/4mW221r
17 days ago
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0
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#MASLD
plays a significant role in post-SVR hepatocellular carcinoma risk. Read More:
https://bit.ly/4q3HLtS
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After Sustained HCV Virologic Response to DAAs, MASLD Increases HCC Risk
MASLD affects the development of hepatocellular carcinoma following SVR in chronic hepatitis C.
https://bit.ly/4q3HLtS
18 days ago
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#Midazolam
plus
#fentanyl
is more effective and better tolerated than midazolam plus
#meperidine
for achieving
#colonoscopy
conscious sedation. Read More:
https://bit.ly/46F0WCB
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Midazolam and Fentanyl Combination Therapy Superior for Colonoscopy Sedation
Compared with midazolam and meperidine, midazolam and fentanyl combination therapy is more efficacious for conscious sedation in colonoscopy.
https://bit.ly/46F0WCB
19 days ago
0
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#Tirzepatide
was noninferior to dulaglutide for the primary endpoint of time to first occurrence of death from
#cardiovascular
causes,
#myocardial
infarction, or
#stroke
. Read More:
https://bit.ly/4gZpXvP
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Cardiovascular Benefit Seen With Tirzepatide in Head-to-Head Trial
SURPASS-CVOT evaluated the efficacy and safety of tirzepatide compared with dulaglutide in adults with T2D and a confirmed ASCVD.
https://bit.ly/4gZpXvP
20 days ago
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Update removes the requirement for
#Leqvio
to be used as an adjunct to
#statin
therapy. Read More:
https://bit.ly/47c9alL
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Leqvio Monotherapy Approved for Adults With Hypercholesterolemia
The FDA has approved a labeling update for Leqvio (inclisiran) allowing for first-line use in the treatment of hypercholesterolemia.
https://bit.ly/47c9alL
20 days ago
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Postcolonoscopy
#CRC
among individuals who test positive following an
#FIT
highlights the need for improved
#colonoscopy
quality and adherence to surveillance guidelines. Read More:
https://bit.ly/46URXvJ
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Missed Lesions, Incomplete Resection Contribute to Postcolonoscopy CRC Rates
Individuals who tested positive after a fecal immunochemical test developed postcolonoscopy CRC within 3 years.
https://bit.ly/46URXvJ
21 days ago
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The
#herpes
#RZV
vaccine may significantly reduce the risk for
#shingles
complications among individuals with
#IBD
. Read More:
https://bit.ly/48ePxKX
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Recombinant Zoster Vaccine Lowers Shingles Risk Among Patients With IBD
The recombinant zoster vaccine significantly lowers the risk for shingles complications among individuals with IBD.
https://bit.ly/48ePxKX
22 days ago
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1
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Children with higher
#polygenic
scores showed accelerated
#BMI
gain from age 2.5 years to adolescence and greater adult weight gain. Read More:
https://bit.ly/4mWrWT5
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Polygenic Scores for BMI Can Improve Prediction of Future Obesity
Adding polygenic scores to early-life body mass index up to age 5 years improved adult body mass index prediction.
https://www.gastroenterologyadvisor.com/news/polygenic-scores-for-bmi-can-improve-prediction-of-future-obesity/
24 days ago
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#Mediterranean
,
#AHEI
, and
#DASH
dietary patterns may reduce the risk of type 2 diabetes across diverse ethnic groups.
#T2D
Read More:
https://bit.ly/46WSkWI
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Three Healthy Dietary Patterns Lower Incidence of Type 2 Diabetes Across Ethnicities
The Mediterranean, AHEI, and DASH dietary patterns were linked to reduced risk of type 2 diabetes across ethnic groups.
https://bit.ly/46WSkWI
25 days ago
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0
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Personalized treatment planning and proactive infection monitoring is important among individuals with
#IBD
. Read More:
https://bit.ly/4pZVPV7
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Mild and Moderate Infections Common Among Patients With IBD
Mild and moderate infections are common among individuals with IBD and tend to be linked to patient characteristics and treatments.
https://bit.ly/4pZVPV7
26 days ago
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#Upadacitinib
is efficacious for helping patients with UC achieve long-term treatment goals. Read More:
https://bit.ly/4h2PpAz
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Upadacitinib for UC Helps Patients Achieve Long-Term Treatment Goals
Upadacitinib is efficacious for achieving and sustaining endoscopic remission, symptom resolution, and normalization of QOL in long-term UC management.
https://bit.ly/4h2PpAz
27 days ago
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#Sepiapterin
, compared with placebo, reduced the mean blood Phe levels from baseline to weeks 5 and 6 by 64.2%. Read More:
https://bit.ly/4pWi4v6
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Sephience Approved for Phenylketonuria in Adults, Children
The FDA has approved Sephience for the treatment of HPA in adult and pediatric patients 1 month of age and older with sepiapterin-responsive PKU.
https://bit.ly/4pWi4v6
27 days ago
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Despite evidence showing a potential protective benefit of probiotics in
#Clostridioides
difficile infection prevention, the overall effect was not significant in clinical settings. Read More:
https://bit.ly/3J10TrF
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Probiotics Show Mixed Results for CDI Prevention in Clinical Settings
Probiotics were favored over placebo for CDI prevention, particularly with twice-daily dosing, but their overall effect on disease incidence was not significant.
https://bit.ly/3J10TrF
28 days ago
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0
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#Prediabetes
is more than twice as common in
#Asian
/PI adolescents than in White youth. Read More:
https://bit.ly/4gVDJiW
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Prediabetes Risk Doubled for Asian, Pacific Islander Adolescents With Overweight, Obesity
Asian/PI adolescents with overweight or obesity had a significantly higher prediabetes prevalence than non-Hispanic White adolescents.
https://bit.ly/4gVDJiW
30 days ago
0
0
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A
#cancer
diagnosis does not appear to lead to improved
#dietary
awareness or healthier eating behaviors in survivors. Read More:
https://bit.ly/3VTQEZ1
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Cancer Diagnosis Not Tied to Later Healthier Eating Habits
Diet-related cancer risk awareness or behaviors are similar between cancer survivors and those without cancer.
https://bit.ly/3VTQEZ1
about 1 month ago
0
0
0
Less invasive transcystic approach of
#LCBDE
may offer more favorable outcomes for
#bile
duct stone management. Read More:
https://bit.ly/3VWoIno
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Transcystic vs Transductal LCBDE More Effective for Common Bile Duct Stones With Gallstones
Transcystic rather than transductal LCBDE is the optimal surgical approach for common bile duct stones with concomitant gallstones.
https://bit.ly/3VWoIno
about 1 month ago
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0
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Meta-analysis highlights the trade-offs between surgery and conservative treatment of
#hemorrhoids
. Read More:
https://bit.ly/41O20kO
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Surgery vs Conservative Treatment for Hemorrhoids: Which Provides Better Relief?
While surgical treatment for hemorrhoids provides better symptom relief, conservative management is safer and less invasive.
https://bit.ly/41O20kO
about 1 month ago
0
0
0
The prevalence of liver
#fibrosis
has more than doubled over the last 20 years among heavy
#alcohol
consumers. Read More:
https://bit.ly/4gjzfCD
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Prevalence of Alcohol-Related Liver Fibrosis More Than Doubled Over Last 20 Years
The prevalence of liver fibrosis has more than doubled over the last 20 years among heavy alcohol consumers.
https://bit.ly/4gjzfCD
about 1 month ago
0
0
0
The estimated five-year risks for
#MACE
-4 were 8.1% for DPP4is, 8.4% for glyburide, 8.6% for glimepiride, and 9.1% for glipizide. Read More:
https://bit.ly/4pgK64a
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Glipizide Linked to Highest MACE-4 Risk in Individuals With Type 2 Diabetes
The highest risk for major adverse cardiovascular events was seen with glipizide for type 2 diabetes vs other sulfonylureas and DPP4is.
https://bit.ly/4pgK64a
about 1 month ago
0
0
0
In multiethnic populations, exposure to per- and polyfluoroalkyl substance (PFAS) mixtures may be associated with increased odds of
#T2D
. Read More:
https://bit.ly/4mOgAkC
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Exposure to PFAS Mixtures Linked to Increased Odds of Type 2 Diabetes
Odds of incident type 2 diabetes increased in association with each tertile increase in exposure to the PFAS mixture.
https://bit.ly/4mOgAkC
about 1 month ago
0
1
0
Combination therapy may be more efficacious than weight loss drugs alone for adults with
#overweight
or
#obesity
who live without
#diabetes
. Read More:
https://bit.ly/4m4HH9N
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Combining Cagrilintide With Semaglutide Amplifies Weight Loss Outcomes
Combination therapy with cagrilintide and semaglutide vs cagrilintide alone, semaglutide alone, and placebo is superior for improving weight loss results.
https://bit.ly/4m4HH9N
about 1 month ago
0
0
0
#Obesity
and
#BMI
are not associated with suboptimal bowel preparation for
#colonoscopy
. Read More:
https://bit.ly/4m7bTkE
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Obesity and BMI Not Linked to Suboptimal Preparation for Colonoscopy
Obesity and body mass index are not associated with suboptimal bowel preparation for colonoscopy.
https://bit.ly/4m7bTkE
about 1 month ago
0
0
0
A significant proportion of young children with biliary atresia (
#BA
) display general neurodevelopmental delays and
#autism
-related traits. Read More:
https://bit.ly/45ZCT0Y
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Pediatric Biliary Atresia Linked to Neurodevelopmental Delays and Autism
Biliary atresia in children is associated with neurodevelopmental delays, including communication, motor, and daily living skills.
https://bit.ly/45ZCT0Y
about 1 month ago
0
0
0
From 2011 to 2021, the rate of
#TNF
inhibitor use throughout
#pregnancy
increased from 55% to 73% among women with
#inflammatory
diseases. Read More:
https://bit.ly/3KduGxn
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A Growing Number of Women Are Continuing TNF Inhibitor Treatment Throughout Pregnancy
A growing number of women with chronic inflammatory diseases are continuing to use TNF inhibitors throughout pregnancy.
https://bit.ly/3KduGxn
about 1 month ago
0
0
0
In multiethnic populations, exposure to per- and
#PFAS
mixtures may be associated with increased odds of
#T2D
. Read More:
https://bit.ly/4mOgAkC
loading . . .
Exposure to PFAS Mixtures Linked to Increased Odds of Type 2 Diabetes
Odds of incident type 2 diabetes increased in association with each tertile increase in exposure to the PFAS mixture.
https://bit.ly/4mOgAkC
about 1 month ago
0
0
0
Combination therapy may be more efficacious than weight loss drugs alone for adults with
#overweight
or
#obesity
who live without
#diabetes
. Read More:
https://bit.ly/4m4HH9N
loading . . .
Combining Cagrilintide With Semaglutide Amplifies Weight Loss Outcomes
Combination therapy with cagrilintide and semaglutide vs cagrilintide alone, semaglutide alone, and placebo is superior for improving weight loss results.
https://bit.ly/4m4HH9N
about 1 month ago
0
0
0
#Obesity
and
#BMI
are not associated with suboptimal
#bowel
preparation for
#colonoscopy
with low-volume agents. Read More:
https://bit.ly/4m7bTkE
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Obesity and BMI Not Linked to Suboptimal Preparation for Colonoscopy
Obesity and body mass index are not associated with suboptimal bowel preparation for colonoscopy.
https://bit.ly/4m7bTkE
about 1 month ago
0
0
0
A significant proportion of young children with
#BA
display general
#neurodevelopmental
delays and
#autism
-related traits. Read More:
https://bit.ly/45ZCT0Y
loading . . .
Pediatric Biliary Atresia Linked to Neurodevelopmental Delays and Autism
Biliary atresia in children is associated with neurodevelopmental delays, including communication, motor, and daily living skills.
https://bit.ly/45ZCT0Y
about 1 month ago
0
0
0
Patients with
#IBS
with self-perceived
#gluten
sensitivity react similarly to wheat, gluten, and sham challenges. Read More:
https://bit.ly/4m4Fz1N
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Wheat, Gluten May Be Safe to Consume for Many With IBS and Self-Perceived Sensitivity
Patients with self-perceived gluten sensitivity and IBS reacted similarly to wheat, gluten, and sham challenges.
https://bit.ly/4m4Fz1N
about 1 month ago
0
0
0
#AOMs
were associated with significant weight regain at eight weeks after drug discontinuation compared with the control group. Read More:
https://bit.ly/4n3OGkY
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Rebound Weight Gain Common After Discontinuing Antiobesity Medications
Anti-obesity medications were linked to significant weight regain at eight weeks after drug discontinuation.
https://bit.ly/4n3OGkY
about 2 months ago
0
0
0
Higher cumulative exposure to uric acid is independently and dose-dependently associated with an increased risk for
#MASLD
. Read More:
https://bit.ly/45X7zzS
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Higher Cumulative Uric Acid Is a Predictor for MASLD Risk
Cumulative uric acid is associated with developing metabolic dysfunction-associated steatotic liver disease.
https://bit.ly/45X7zzS
about 2 months ago
0
0
0
Preoperative staging is important to better allocate individuals to
#TEM
or
#ESD
for removing rectal
#neuroendocrine
tumors. Read More:
https://bit.ly/3IfOVKi
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Higher Recurrence Rate for Rectal Neuroendocrine Tumors Removed by TEM vs ESD
While the efficacy of TEM is higher than ESD for removing rectal neuroendocrine tumors, TEM has a higher recurrence rate.
https://bit.ly/3IfOVKi
about 2 months ago
0
0
0
Patients with immune-mediated inflammatory diseases using tumor
#necrosis
factor inhibitors are not at higher risk of heart failure than patients who are treated with placebo or conventional non-biologic treatments. Read More:
https://bit.ly/42iyNOZ
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Anti-TNFs for Inflammatory Diseases Do Not Increase Risk for Heart Failure
Tumor necrosis factor inhibitor use in patients with IMIDs did not increase the risk of de novo heart failure or worsen existing heart failure.
https://bit.ly/42iyNOZ
about 2 months ago
0
1
0
Topline data were announced from two phase 3 trials evaluating
#obefazimod
in adults with moderately to severely active
#UC
. Read More:
https://bit.ly/4m40Zw5
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Obefazimod Induces Clinical Remission in Ulcerative Colitis Trials
The ABTECT clinical program included the randomized, double-blind, placebo-controlled phase 3 ABTECT-1 and ABTECT-2 trials.
https://bit.ly/4m40Zw5
about 2 months ago
0
0
0
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