#SimulAdren underwent a major upgrade. Version 2.0 introduces significant new features, e.g., support for different models, initial conditions, first-order delay kinetics (ASIA elements), and model continuation. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy. pubmed.ncbi.nlm.nih.gov/41852474/ doi.org/10.3389/fend...

30 years of #SimThyr in #Marchintosh 2026: #SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7. Thanks to the fact that the code was based on the #Pascal programming language, the software is highly portable, but runs with full native speed.

#Simuladren, a simulator for the #HPA axis based on #CyberUnits Bricks, has been updated to version 1.2. This upgrade introduces support for XML files according to #MIASE and #MIRIAM guidelines and high-res displays on Windows. simuladren.sourceforge.io doi.org/10.5281/zeno...

Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics

#SimulaBeta and #SimThyr provide the theoretical foundations for this revolutionary approach.

Multiple feedforward motifs and feedback loops maintain #thyroid #homeostasis and #allostasis. The mechanism of relational stability maintains T3 in a balanced and safe range, even in conditions of declining thyroid function. doi.org/10.1007/978-... 🧪 🩺 #MedSky

Signalling via #thyroid hormones is more than T3 and T4. It involves 27 molecules based on the thyronine skeleton, 10 transmembrane transporters, 3 deiodinases, 6 receptors, and 4 types of action, unfolding a complex firework of possibilities, explaining health and disease. doi.org/10.1007/978-...

Our book is now available in printed form. Use the code SPRAUT to get a discount of 20% at Springer Nature. link.springer.com/book/9789819...

Computer simulations with #SimThyr enhance our understanding of the physiology of hypothalamic-pituitary-thyroid feedback control. This applies, for example, to the evolution of #TACITUS syndrome. #thyroid #hypothyroidism #NTIS #biocybernetics doi.org/10.1007/978-...

Our eBook on #hypothyroidism has been published. The new cybernetic theory presented here summarises our scientific work of more than 20 years and lays the foundation for improved diagnosis and therapy of #thyroid disorders. The book is available in EPUB and PDF formats. doi.org/10.1007/978-...

Medical treatment of #hyperthyroidism, i.e. #thyrotoxicosis due to overproduction of #thyroid hormone, remains a challenge. We developed a new dosage methodology based on model predictive control (MPC), which is faster and more stable than the usual trial-and-error approach. doi.org/10.1016/j.if...

The method of structure parameter inference approach, i.e. #SPINA-Thyr and #SPINA_Carb, has predictive power in the setting of #P4_medicine. In a large population sample, four SPINA parameters, #SPINA-GT, #SPINA-GD, #SPINA-GBeta and #SPINA-DI, predicted all-cause mortality. doi.org/10.53201/LEI...

Calculating #SPINA-GT, #thyroid​'s secretory capacity, and #SPINA-GD, total #deiodinase activity, is evolving towards a standard method of research in #thyroidology, as shown by more than 100 citations of one of our defining papers. 🧪🩺 pubmed.ncbi.nlm.nih.gov/27375554/ doi.org/10.3389/fend...

Digitale Zwillinge in der Endokrinologie: Der Weg zu einer prädiktiven und personalisierten Medizin. 🧪🩺 blog.endokrinologie.net/digitale-zwi...

Gratulation an @drjwdietrich.bsky.social für den Heinz-von-Foerster Preis für Organisationskybernetik!

Die Deutsche Gesellschaft für #Kybernetik, Informations- und #Systemtheorie hat Peter K. Fleissner und mir den Heinz von Foerster-Preis verliehen. Ich danke meinen Lehrer:innen und Kooperationspartner:innen, die meine Arbeit im Laufe der letzten 30 Jahre möglich gemacht haben.

🩺🧪 Sadly, John Midgley, a pioneer in #thyroid diagnostics and co-author of multiple papers by our group, passed away. Read Rudolf Hoermann's obituary at The Guardian: www.theguardian.com/society/2024...