🧪 🩺 #MedSky @medsky.social #Endocrinology #Endosky

Wiley sent us a note that our paper defining the static disposition index #SPINA-DI is among the top-viewed articles of the Journal of Diabetes. pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753... www.livivo.de/doc/M38169110

Hier ein Beispiel für eine berühmte Simulation mit einem #Analogrechner: Das Modell der #Insulin-Glukose-Homöostase von Bolie (1960). Dieses Modell hatte einen enormen Einfluss auf unser Verständnis des #Diabetes mellitus und lässt sich mit modernen Analogrechnern jetzt wieder direkt reproduzieren.

#SimulAdren underwent a major upgrade. Version 2.0 introduces significant new features, e.g., support for different models, initial conditions, first-order delay kinetics (ASIA elements), and model continuation. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy. pubmed.ncbi.nlm.nih.gov/41852474/ doi.org/10.3389/fend...

30 years of #SimThyr in #Marchintosh 2026: #SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7. Thanks to the fact that the code was based on the #Pascal programming language, the software is highly portable, but runs with full native speed.

#Trndi is a #glucose monitoring application written in #Object_Pascal. It fetches interstitial sugar readings from continuous glucose monitors (CGM) via different APIs and shows them on the desktop. It also presents a trend over time, colouring, and JavaScript extensions. trndi.app

The theory underlying this advanced method was developed based on computer simulations written in #Object_Pascal. pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753... www.livivo.de/doc/M38169110 #Pascal #programming

Diagnosis of #diabetes mellitus and #prediabetes: A simple calculation may be better than a complex test. 🧪 🩺 #MedSky @medsky.social #Endosky #Endocrinology medicalxpress.com/news/2024-01...

#CyberUnits Bricks has been released in version 2.1.0. This version introduces a proportional-integral (PI) block, scaling for systems diagrams, a solver for algebraic equations, extended ASIA elements, additional demo programs, and bug fixes. cyberunits.sf.net doi.org/10.5281/zeno...

Metabolische Phänotypisierung durch mathematische Modellierung der #Insulin-Glukose-Homöostase Mathematische Modelle und Simulationen der Insulin-Glukose-Homöostase sind nützlich, da sie physiologische Erkenntnisse liefern und klinische Entscheidungen unterstützen. www.doccheck.com/de/detail/ar...

Previsione precoce semplice e affidabile del diabete blogpinali.wordpress.com/2024/01/23/p...

Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics

SPINA Carb 5.1.0 Cyclone has been released in its final version. #SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno... #SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA

Release candidate 2 of #SPINA_Carb is available for testing. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin. pubmed.ncbi.nlm.nih.gov/40217596/

I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes. onlinelibrary.wiley.com/doi/toc/10.1... doi.org/10.1111/1753...

Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der #Insulintherapie bei #Diabetes mellitus Typ 1. www.klinikum-bochum.de/fachbereiche...

The method of structure parameter inference approach, i.e. #SPINA-Thyr and #SPINA_Carb, has predictive power in the setting of #P4_medicine. In a large population sample, four SPINA parameters, #SPINA-GT, #SPINA-GD, #SPINA-GBeta and #SPINA-DI, predicted all-cause mortality. doi.org/10.53201/LEI...

The disposition index of #insulin-glucose #homeostasis is an estimate for its loop gain. Its determination used to be complex, requiring clamp, IVGTT or OGTT experiments. We have developed a fasting-based method that is simpler and better 🧪🩺 pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753...

Which programming language is fit for high-performance computer simulations in biomedical #cybernetics? We found that #Free_Pascal generates faster code than S/R and #Python. Interestingly, Object #Pascal even outperforms #Swift and C++. 🧪🩺 doi.org/10.14201/adc... revistas.usal.es/cinco/index....

Die Deutsche Gesellschaft für #Kybernetik, Informations- und #Systemtheorie hat Peter K. Fleissner und mir den Heinz von Foerster-Preis verliehen. Ich danke meinen Lehrer:innen und Kooperationspartner:innen, die meine Arbeit im Laufe der letzten 30 Jahre möglich gemacht haben.

Gratulation an @drjwdietrich.bsky.social für den Heinz-von-Foerster Preis für Organisationskybernetik!

A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal. Today, this innovative approach is covered by all major press agencies and news channels all over the globe. news.rub.de/english/pres...

Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the insulin-glucose feedback loop and for early diagnosis of diabetes mellitus. 🩺 doi.org/10.1111/1753...

#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0. simulabeta.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...