Previsione precoce semplice e affidabile del diabete blogpinali.wordpress.com/2024/01/23/p...

Mathematical modelling of #insulin-#glucose #homeostasis delivers new and improved methods for metabolic endotyping. #prediabetes #diabetes #metabolic_syndrome #betacell pubmed.ncbi.nlm.nih.gov/36271244/ doi.org/10.1038/s415...

Gestational #diabetes mellitus (GDM) is linked to significant adverse outcomes for both mothers and their offspring. Since #SPINA-GBeta outperforms #HOMA-Beta, its use is advised as a preferred calculated #biomarker for the evolution and pathophysiology of #GDM. pubmed.ncbi.nlm.nih.gov/40943638/

Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics

Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study. pubmed.ncbi.nlm.nih.gov/40579157/ doi.org/10.1210/clin...

For the diagnosis and management of #hypothyroidism, measuring #TSH (thyrotropin) concentration is necessary, but it isn’t sufficient. Additional #biomarkers help to improve diagnostic power and to identify #endotypes of dysregulation. doi.org/10.1007/978-... 🧪 🩺 #MedSky

#SPINA_Thyr and #SPINA_Carb, two implementations of the structure parameter inference approach (SPINA), provide evidence-based improved methods for diagnosis and endotyping of endocrine diseases. Now, thoroughly tested apps for Mac and Windows are available for free download. spina.sf.net

SPINA Carb 5.1.0 Cyclone has been released in its final version. #SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno... #SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA

Multiple feedforward motifs and feedback loops maintain #thyroid #homeostasis and #allostasis. The mechanism of relational stability maintains T3 in a balanced and safe range, even in conditions of declining thyroid function. doi.org/10.1007/978-... 🧪 🩺 #MedSky

In patients undergoing #thyroid surgery due to nodules, #SPINA-GT is lower (and the set point of the homeostatic system higher) in cases of thyroid cancer compared to benign nodules. doi.org/10.3389/fend...

Signalling via #thyroid hormones is more than T3 and T4. It involves 27 molecules based on the thyronine skeleton, 10 transmembrane transporters, 3 deiodinases, 6 receptors, and 4 types of action, unfolding a complex firework of possibilities, explaining health and disease. doi.org/10.1007/978-...

Our book is now available in printed form. Use the code SPRAUT to get a discount of 20% at Springer Nature. link.springer.com/book/9789819...

Computer simulations with #SimThyr enhance our understanding of the physiology of hypothalamic-pituitary-thyroid feedback control. This applies, for example, to the evolution of #TACITUS syndrome. #thyroid #hypothyroidism #NTIS #biocybernetics doi.org/10.1007/978-...

Our eBook on #hypothyroidism has been published. The new cybernetic theory presented here summarises our scientific work of more than 20 years and lays the foundation for improved diagnosis and therapy of #thyroid disorders. The book is available in EPUB and PDF formats. doi.org/10.1007/978-...

Release candidate 2 of #SPINA_Carb is available for testing. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

#Thyroid hormones play a pivotal role in #thermoregulation and the attunement to hot and cold #climate​s. Recent research found global patterns of variants in the UCP1 and UCP3 genes and #SPINA-GD (step-up #deiodinase activity), suggesting integrated adaptation. 🧪 🩺 #MedSky doi.org/10.3390/biol...

After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Calculating #SPINA-GT is useful in paediatrics, as recently shown in a research paper by the Medical School of Patras. SPINA-GT is significantly reduced in subclinical hypothyroidism and even in the upper 2 quartiles of normal TSH. pubmed.ncbi.nlm.nih.gov/40230485/ doi.org/10.3389/fend...

#Thyroid hormones profoundly impact the #cardiovascular system. They act at all levels, ranging from the tier of ion currents over cellular processes to the macroscopic levels of myocardial tissue and even the whole organism. 🧪 🩺 #MedSky doi.org/10.3389/fcvm... pubmed.ncbi.nlm.nih.gov/36046184/

#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin. pubmed.ncbi.nlm.nih.gov/40217596/

Medical treatment of #hyperthyroidism, i.e. #thyrotoxicosis due to overproduction of #thyroid hormone, remains a challenge. We developed a new dosage methodology based on model predictive control (MPC), which is faster and more stable than the usual trial-and-error approach. doi.org/10.1016/j.if...

#Diabetes mellitus is common in hidradenitis suppurativa (acne inversa). Affected persons are faced with low insulin sensitivity ( #SPINA-GR ) and a lack of dynamic compensation via beta-cell function ( #SPINA-GBeta ), resulting in a reduced disposition index ( #SPINA-DI ). doi.org/10.3390/jcm1...

Again, a study shows that #environment​al #toxicant​s, i.e. endocrine #disruptor​s, strongly affect #thyroid #homeostasis. For calculated biomarkers, i.e. #SPINA-GT and #SPINA-GD, this effect is more pronounced than for #TSH. pubmed.ncbi.nlm.nih.gov/39826653/ doi.org/10.1016/j.en...

Growing evidence supports a role of sensorimotor and autonomic #neuropathy in #syndrome_T or #SORSHOT, i.e. reduced quality of life in treated #hypothyroidism. #SPINA_GT and #SPINA_GD predict nerve function and depression. pubmed.ncbi.nlm.nih.gov/38811750/ doi.org/10.1038/s415...

Again, a study showed a strong influence of endocrine disruptors on #thyroid homeostasis. Exposure to butylparaben significantly reduces #SPINA-GD, whereas ethylparaben slightly increases #SPINA_GT in pregnancy. pubmed.ncbi.nlm.nih.gov/39889471/ doi.org/10.1016/j.ec...

#SPINA_GD is reduced in major #depression, #bipolar disorder and #schizophrenia, whereas #SPINA_GT is elevated in schizophrenia and bipolar disorder, marking a unique profile of #thyroid_allostasis. pubmed.ncbi.nlm.nih.gov/38277991/ doi.org/10.1016/j.ps...

#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry. 🩺 pubmed.ncbi.nlm.nih.gov/38502972/ doi.org/10.1016/j.eb...

🧪 #SPINA_Thyr may be useful for monitoring of #endocrine disruptors. #SPINA_GD correlates to paraben excretion, and #SPINA-GT is modified due to exposure to butylparaben. doi.org/10.1007/s113... pubmed.ncbi.nlm.nih.gov/38038926/

I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes. onlinelibrary.wiley.com/doi/toc/10.1... doi.org/10.1111/1753...

6 months after #COVID-19, #SPINA-GD correlates negatively to the severity of fatigue in patients affected by Long COVID (PASC). pubmed.ncbi.nlm.nih.gov/39247915/ doi.org/10.3389/fend...

Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der #Insulintherapie bei #Diabetes mellitus Typ 1. www.klinikum-bochum.de/fachbereiche...

The method of structure parameter inference approach, i.e. #SPINA-Thyr and #SPINA_Carb, has predictive power in the setting of #P4_medicine. In a large population sample, four SPINA parameters, #SPINA-GT, #SPINA-GD, #SPINA-GBeta and #SPINA-DI, predicted all-cause mortality. doi.org/10.53201/LEI...

Calculating #SPINA-GT, #thyroid​'s secretory capacity, and #SPINA-GD, total #deiodinase activity, is evolving towards a standard method of research in #thyroidology, as shown by more than 100 citations of one of our defining papers. 🧪🩺 pubmed.ncbi.nlm.nih.gov/27375554/ doi.org/10.3389/fend...

The disposition index of #insulin-glucose #homeostasis is an estimate for its loop gain. Its determination used to be complex, requiring clamp, IVGTT or OGTT experiments. We have developed a fasting-based method that is simpler and better 🧪🩺 pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753...

www.medscape.com/viewarticle/... 🩺🧪

Endocrine disruptors have a strong effect on the peripheral #thyroid hormone metabolism. A recent study showed a nonlinear dose-response relationship between #PFAS and step-up deiodinase activity (#SPINA_GD). pubmed.ncbi.nlm.nih.gov/39556482/ doi.org/10.1210/clin...

Should we, therefore, classify #syndrome_T as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic #neuropathy that depend on autoimmunity and #thyroid's secretory capacity (#SPINA_GT).

Our newest paper provides new insights into the conundrum of #syndrome_T / #SORSHOT. #Anxiety and #depression are significantly more common in autoimmune #thyroiditis compared to healthy controls. 🧪🩺 #thyroid #qol doi.org/10.1038/s415...

Telefonsprechstunde zu Schilddrüsenerkrankungen Zum Weltschilddrüsentag am 25. Mai bietet das Schilddrüsenzentrum Bochum eine spezielle Telefonsprechstunde an, die allen Interessierten und Betroffenen offensteht: Samstag, 25. Mai, von 11:00 bis 14:00 Uhr unter der Rufnummer (0234) 509-6095

🩺🧪 Sadly, John Midgley, a pioneer in #thyroid diagnostics and co-author of multiple papers by our group, passed away. Read Rudolf Hoermann's obituary at The Guardian: www.theguardian.com/society/2024...

#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry. 🩺 pubmed.ncbi.nlm.nih.gov/38502972/ doi.org/10.1016/j.eb...

Our newest paper has been published. Based on machine learning with k-medoids #clustering we identified three different signatures of #thyroid #homeostasis that predict the prognosis of patients with #Takotsubo syndrome. 🧪🩺 pubmed.ncbi.nlm.nih.gov/38502972/ doi.org/10.1016/j.eb...

The #kynurenine pathway is a series of chemical reactions that produce NAD+ and other mediators with immunomodulatory function. A recent study shows that this pathway is altered in autoimmune #thyroiditis. Several metabolites correlate with #SPINA_GD. 🧪 🩺 pubmed.ncbi.nlm.nih.gov/38514790/

#SPINA_GD is reduced in major #depression, #bipolar disorder and #schizophrenia, whereas #SPINA_GT is elevated in schizophrenia and bipolar disorder, marking a unique profile of #thyroid_allostasis. pubmed.ncbi.nlm.nih.gov/38277991/ doi.org/10.1016/j.ps...

#SPINA_Thyr 4.2.1 released. This new version fixes several minor bugs. It is compatible with Windows (32 and 64 bits), macOS (Intel and Apple Silicon) and several Unix and Linux variants. spina.sourceforge.net doi.org/10.5281/zeno... doi.org/10.5281/zeno... 🩺 🧪

Breaking news: In combination with whole-exome sequencing, #SPINA_Carb helped to discover a new form of #MODY #diabetes, caused by an atypical missense variant in the #RyR2 gene (coding the the type 2 #ryanodine receptor). doi.org/10.3389/fend... 🧪🩺

A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal. Today, this innovative approach is covered by all major press agencies and news channels all over the globe. news.rub.de/english/pres...

A single blood sample may improve early diagnosis of diabetes, thanks to mathematical modelling 🧪🩺 www.growkudos.com/publications...

#SPINA_Carb has high discriminatory power for the distinction between #diabetes and normal glucose homeostasis. SPINA-GBeta is better than HOMA-Beta, SPINA-GR is better than HOMA-IR and QUICKI, but SPINA-DI is best, being even more powerful than ivGTT. 🩺🧪 pubmed.ncbi.nlm.nih.gov/38169110/