Excited to share our latest Nature publication, headed by the Pacold lab. Our experimental compound shows great promise as a novel, mechanistic treatment for a pediatric disorder that can prove fatal. It also highlights the therapeutic relevance of the cerebellum. #neuroskyence tinyurl.com/yh9736m9

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

In case you missed it, we recently published one of the largest studies of the aging brain. It reveals new insights into how the brain ages including possible connections between diet, inflammation, and brain health. 🧠📈 More at alleninstitute.org/news/key-pla... #studyBRAIN #BrainAwarenessWeek

To understand the brain, we must first understand its parts — the cells. 🧠📈 Together with our partners across the country, we're cataloging cell types in the brain with the most detailed map of the motor cortex ever. 🎬 www.youtube.com/watch?v=ylt2... #BrainWeek #BrainAwarenessWeek #studyBRAIN

Viewpoint with Mark Edwards debating the relevance of clinical phenomenology in movement disorders! doi.org/10.1002/mds....

New in 𝐶𝑒𝑙𝑙 𝗣𝗮𝘆(𝗹𝗼𝗮𝗱) 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 𝘁𝗵𝗲 𝗡𝗼𝘀𝗲 Intranasal 𝐿𝑎𝑐𝑡𝑜𝑏𝑎𝑐𝑖𝑙𝑙𝑢𝑠 𝑝𝑙𝑎𝑛𝑡𝑎𝑟𝑢𝑚 (Lp) engineered to release drugs in the olfactory epithelium, facilitating their transport to the brain intranasal Lp-secreted leptin (appetite-regulating hormone) reduced obesity in mice www.cell.com/cell/fulltex...

FDA approves new pain killer- First non-opioid analgesic in decades targets sodium channels. #painresearch #physio #neuroskyence 🛟🧪 www.nature.com/articles/d41...

VNS at mid-intensity decreased anxiety-like behavior without affecting reward or aversion in rats. This intensity also increased c-Fos expression in noradrenergic NTS neurons while reducing it in the LC. #neuroskyence 🩺 Butler et al. Brain Stim www.sciencedirect.com/science/arti...

I think it is obvious we need to pay 'more' attention to resilience factors, and invest 'more' in understanding what is vulnerable. How can we use 'intrinsic characteristics' of cells to our advantage? To use a Star Wars analogy, 'use the force Luke.' Let us move – a fortiori – with stronger reason.

Guess what? There are early motor signs even in Alzheimer's and Lewy Body Disease. Are there early motor features that predict pathology or co-pathology? Spoiler alert: Look at the face. Daniel Oh and colleagues collected the information and collected brains to teach us.

Mysterious Blobs Found inside Cells Are Rewriting the Story of How Life Works Tiny specks called biomolecular condensates are leading to a new understanding of the cell www.scientificamerican.com/article/myst...

🚨 New Research! 🚨 Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing! www.biorxiv.org/content/10.1...

The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/basal-gangli...

New from @sarahdonofrio.bsky.social: Aging leads to patterned Purkinje cell loss in the cerebellum, seen in both mice and humans. More insights into how aging shapes neuronal vulnerability here: www.biorxiv.org/content/10.1... #neuroskyence

How important are your #postdoc years in the likelihood of you staying & succeeding in #academia? In our newly published paper in @pnas.org, "Postdoc Publications and Citations Link to Academic Retention and Faculty Success," we study the journey of #CareerSuccess of ~45,000 #postdocs. 🧵1/7

Nature Neuroscience Dynamical constraints on neural population activity www.nature.com/articles/s41...

New study demonstrates that tiny one-celled sea creatures use the same type of molecular machinery that #neurons and muscle cells use to communicate. Could be a pathway to advance #AI and #robotics? scienceblog.com/553045/tiny-... #neuroscience

Huge congrats to @sarahdonofrio.bsky.social for her beautiful science communication piece, highlighted in Nature Features and Opinion! Dive into the fascinating story of how a neuroscientist unraveled his own long COVID mystery. www.youcanknowthings.com/how-one-neur.... #neuroskyence

Lots of good discussion on this compelling new paper this week: www.cell.com/neuron/abstr... I'd like to offer my $0.02 along with some historical background that the article didn't give. 1/ #Neuroskyence #PsychSciSky

really great thread by Blake. Each neuron in an artificial neural network (ANN) isn't supposed to accurately model a neuron in the brain. Instead, ANNs are good models of computation (through dynamics/manifolds) based on the collective activity of simpler "functions" (i.e., the neurons)

Very proud to share a new review (more like a long perspective), just out in Science Advances: rebrand.ly/mdbi8q8. Ilana Nisky and Tamar @cambridgeuni.bsky.social joined heads (brains) to reimagine how to make the most out of artificial haptic interfaces. A thread (1/8)

Final first-author paper from my postdoc w/ the brilliant @sylvainbaillet.bsky.social + crew! We find converging evidence for a pathway b/w norepinephrine ➡️ cortical alpha rhythms ➡️ cognitive dysfunction in #Parkinson's disease academic.oup.com/brain/advanc... 🧵👇 (1/n)

Brains balance individual neuron activity and scalable teamwork using a fractal hierarchy, optimizing efficiency and adaptability. This universal principle, found across species, enables resilience and rapid adaptation. #Neuroscience #BrainEfficiency #FractalApproach #Neurons #BrainResearch

Multi-timescale neural dynamics for multisensory integration www.nature.com/articles/s41... #neuroscience

I'm excited about this new analysis approach because we can now estimate when changes in strategy, goal choice, conflict etc. occur in open state spaces. Providing metrics for studies with patients & sec-sec metrics for upcoming fMRI data and existing iEEG data with Sea Hero Quest #neuroskyence

Our paper on MouseGoggles - an open-source mini VR headset for mice - just came out! Really excited about finally integrating eye-tracking into the headset. Nice working with you @hongyuchang.bsky.social! www.nature.com/articles/s41... github.com/sn-lab/Mouse... #neuroskyence

Since I need a first bsky post, here's a rehash of @nickhedger.bsky.social's thread announcing our preprint with Kendrick Kay & Thomas Naselaris. TLDR; High-level visual cortex is tiled with maps 'multiplexing' vision and touch. tinyurl.com/seesoma 🧵 1/n

Congrats to Sam Mestern, Ph.D. student at @westernu.bsky.social, for winning the MapMySpikes challenge! His tool, PatchOTDA, excelled in mapping electrophysiological data to molecular properties. 🧠📈 More on his tool and the MapMySpikes challenge: alleninstitute.org/news/canadia...

Really nice paper here. No one is really paying attention to aging as a factor in gene therapy for neurological disorders (disproportionally affecting elderly people). www.cell.com/molecular-th...

Delighted to share an update to our preprint, reviewed at @elife.bsky.social, and now sent back for re-review. Colossal work by the team and driven home by @mathiasgua.bsky.social Quick 🧵 of what's new - www.biorxiv.org/content/10.1...

Link to the original study in @elife.bsky.social is here: elifesciences.org/articles/89131

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

Join us for the 2025 Cerebellum GRS! We will start accepting applications for GRS Cerebellum from Dec 19 until all 70 spots fill up - so don't wait too long. Remember you can change your abstract until March. Apply here: www.grc.org/cerebellum-g... @kimlinda.bsky.social #Cerebellum #neuroskyence

We will start accepting applications for GRS Cerebellum from Dec 19 until all 70 spots fill up—so don’t wait too long! Who else is planning to join? Let’s dive into cerebellar science together! Apply here: www.grc.org/cerebellum-g... #CerebellumGRS @carobellum.bsky.social

Made a starter pack for researchers who are actively working on or have an interest in the cerebellum. DM me to be added or reply to this thread! 🧠🤏🏻 go.bsky.app/7X4ekSH #neuroscience #neuroskyence #cerebellum #neuroimaging #dbs #fmri

Today's Nobel lecture by John Hopfield is brilliant and moving. Fascinating to hear how hard he worked at finding the right problem. And how he arrived at that fateful discovery that got many of us into neuroscience. (And how it was useful that PNAS was unreviewed!) www.youtube.com/live/lPIVl5e...

Let me tell you a story – one of the more haunting I’ve seen in 20 years of journalism. It’s about greed, death and denial. It took two years to unravel one doctor’s myth, a hospital’s complicity in creating it, and a documented trail of suspicious deaths…🧵

A study in Nature Medicine finds that deep brain stimulation of a region called the lateral hypothalamus improves walking and promotes recovery in humans and rodents with spinal cord injury. https://go.nature.com/3Vlosyl 🧪

Now updated with more resources, and the ability to search and filter by different categories! Link: nrennie.rbind.io/data-science... #RStats #DataScience

Do octopuses dream? In any case, can't get enough of watching them sleep 😴🐙 Look at this symphony of patterns and movements! Incredible. youtu.be/006DjAixu9E?...

How the brain coordinates the activity of its many muscles to achieve successful control remains an enigma. www.cell.com/issue/S0896-...

As a grant reviewer, what do you really wish people would do/not do? Not big things, like find a significant question/innovative method/be consistent with aims Little things, like bold each acronym the first time it’s used. Add your pet peeves ⬇️ #HiddenCurriculum #Research

🧠🍽️New study reveals how your liver talks to the brain to regulate eating habits: Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake 🔗 www.science.org/doi/10.1126/... #CircadianRhythms #Neuroskyence

Cool new sequence work potentially reconciling different views about habitual and more flexible sequences in Nat Neuro: #neuroscience 🧠 🧪 The role of motor cortex in motor sequence execution depends on demands for flexibility

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!

1/ 🧵 Free resources for scientists 💡 Covering research skills, careers, #SciComm, leadership, activism and more, everything in this thread appears on our Learning Resources page, with tips for researchers and academics at any career stage. #AcademicChatter #ECRChat https://buff.ly/4f8vIpk

Ever look high and low for the right bioart for presentations? Here are a few NIH resources: bioart.niaid.nih.gov Or try some ideas in 3D: 3d.nih.gov

Nice Commentary in @elife.bsky.social on new discovery linking Beta rhythms and the dopamine system: Brain Activity: Unifying networks of a rhythm elifesciences.org/articles/104... #neuroskyence #dopamine #beta-waves

Can computer vision help us turn clinical videos into quantifiable digital biomarkers of Dystonia? Our recent paper suggests yes! Let‘s recap first. www.nature.com/articles/s41...