Simon A. Sharples, PhD π¨π¦
@neurosharps.bsky.social
π€ 62
π₯ 95
π 12
Research Fellow studying motor systems neuroscience in Cincinnati
Check out our recent publication from my postdoc in
@uniofstandrews.bsky.social
in the Miles Lab published in
@cp-cellreports.bsky.social
that describes a cholinergic spinal circuit that is vital for fine-tuning motor output during breathing.
www.sciencedirect.com/science/arti...
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A cholinergic spinal pathway for the adaptive control of breathing
The ability to amplify motor neuron (MN) output is essential for generating high-intensity motor actions. This is critical for breathing that must be β¦
https://www.sciencedirect.com/science/article/pii/S2211124725008496?via%3Dihub
2 months ago
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Want to learn more about gamma motoneurons? Check out our recent preprint from my postdoctoral work in the Miles Lab
@uniofstandrews.bsky.social
providing insight into how these cells are tuned to support motor function.
www.biorxiv.org/content/10.1...
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Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons
Precise motor control relies on continuous sensory feedback from muscles, a process in which gamma motoneurons play a key role. These specialized spinal neurons innervate intrafusal muscle fibres, mod...
https://www.biorxiv.org/content/10.1101/2025.06.29.661254v1
4 months ago
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reposted by
Simon A. Sharples, PhD π¨π¦
The Journal of Physiology
4 months ago
Congratulations & welcome to Dr Simon Sharples from
cincychildrens.bsky.socialβ¬
who joins us as one of our 2025 Editorial Board Fellows! π π
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reposted by
Simon A. Sharples, PhD π¨π¦
John Tuthill
8 months ago
Just learned that the Sensorimotor Neuroscience (SMN) study section is postponed indefinitely. Over 100 proposals to understand and treat sensorimotor diseases that will not be evaluated or funded. Thousands of hours wasted by writers and reviewers. All due to the Republican block on NIH operation.
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π¨ New Research Alert! π¨ Thrilled to share my final PhD paperβalso my first as corresponding author, recently published in @iScience! We investigated spinal circuits that contribute to episodic locomotor activity.
www.sciencedirect.com/science/arti...
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Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord
Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-inβ¦
https://www.sciencedirect.com/science/article/pii/S2589004225002317?via%3Dihub
8 months ago
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We've always wondered what V0g's were up to. Now we're a big step closer to knowing! Nice to see this great work out!
add a skeleton here at some point
8 months ago
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reposted by
Simon A. Sharples, PhD π¨π¦
Tuan Bui
8 months ago
If you're interested in spasticity, we've just published a reliable way to optogenetically induce hindlimb spasticity after spinal cord injury. All the credit goes to PhD graduate Sara Goltash and postdoc
@alaliberte.bsky.social
www.sciencedirect.com/science/arti...
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It's shaping up to be a fantastic summer for motor control meetings. Registration for the second Motor Circuits Meeting hosted in St Andrews June 17-20 has just opened. Looking forward to catching up with friends and colleagues at the meeting!!
motor-circuits.wp.st-andrews.ac.uk/registration/
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Registration and Call for Abstracts β Motor Control: Spinal Circuits and Beyond
https://motor-circuits.wp.st-andrews.ac.uk/registration/
8 months ago
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Really looking forward to this!
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8 months ago
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π¨ New Research! π¨ Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing!
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.01.20.633641v1
9 months ago
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