Why Do Filamentous Actinomycetota Produce Such a Vast Array of Specialized Metabolites? www.annualreviews.org/content/jour...

Discovery and Biosynthetic Interrogation of a Cobalt-Containing Terpene-Polyketide-Nonribosomal Peptide Tribrid with Anticoronavirus Activity | Journal of the American Chemical Society pubs.acs.org/doi/abs/10.1...

NMRMind: A Transformer-Based Model Enabling the Elucidation from Multidimensional NMR to Structures | Analytical Chemistry pubs.acs.org/doi/abs/10.1...

Thrilled to share with you a recent work from our group: Computational Mass Spectrometry-Based Reassessment of European Amanita sect. Phalloideae Cyclopeptidome | Journal of Natural Products pubs.acs.org/doi/10.1021/... Please have a look to the associated MassQL compendium.

Discovery of Antivirulence ClpP Inhibitors by Self‐Resistance Gene‐Guided Mining Coupled with Dual Functional Screening - Wang - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

🚨 New Paper Alert 🚨 Great writing project with @adafede.bsky.social & Mehdi Bennidir and colleagues! @w-u-r.bsky.social #metabolomics #CompMetabolomics #naturalproducts #discovery #libraries pubs.rsc.org/en/content/a...

@mehdibeni.bsky.social drove it forward, and it was a pleasure to contribute with @robinschmid.bsky.social, @Wout Bittremieux, @Olivier Cailloux, and @jjjvanderhooft.bsky.social. It places the scalability of MS-based metabolomics for natural extracts as a central challenge rather than a side issue.

What a relief! Finally, MS2DECIDE is no longer a preprint @chemrxiv.org It has just been published @ChemistryMethods chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... @BioCIS @univparissaclay.bsky.social @lamsade.bsky.social @univdauphine.bsky.social @cnrs-paris-saclay.bsky.social @cnrs.fr

Increasing the Scale of the Mass Spectrometry Query Language Compendium with Explainable AI | Analytical Chemistry pubs.acs.org/doi/10.1021/...

Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)

Congrats to postdoc Zhe Zhou on her paper out today in @cp-cellhostmicrobe.bsky.social showing that gut bacteria cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Thanks to collaborators Angela Jiang and Xiaofang Jiang at NIH. www.sciencedirect.com/science/arti...

Have a look to our just accepted manuscript @orgchemfront.rsc.org We bypassed the Abnormal Chichibabin reaction and accessed to pre-haouamine thank you @univparissaclay.bsky.social for gold open access @BioCIS pubs.rsc.org/en/content/a...

After a new space telescope scan, signs of life on the exoplanet K2-18b remain elusive. It's even left scientists questioning what it will take to recognize life beyond our solar system. My story [gift link] nyti.ms/4o32ZH1

Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset | Analytical Chemistry pubs.acs.org/doi/10.1021/...

Time for Bordeaux wine tasting @isvv-bordeaux.bsky.social under the guidance of Axel Marchal. @aferp.bsky.social

Directing Biosynthesis has been connecting #Biosynthesis researchers for over a decade – and the next conference takes place from 29 June – 1 July 2026. It’s a key opportunity to connect with colleagues across all career levels. Will you be joining us? rsc.li/dbviii #DBVIII #SkyChem

Enjoying #AFERP-STOLON symposium in Bordeaux for the three next coming days. Happy to meet old friends of the NP Chemistry community.

🔓Check out this #OpenAccess review in our MS Metabolomics themed collection by Charlotte Simmler & co @cnrs.fr describing the complex chemistry of benthic seawater from exometabolite sampling strategies to MS-based metabolomics #natprod Read it in full on our website👇

Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

Design and Biosynthesis of Ornithine 8-Containing Semaglutide Variants with a Click Chemistry-Modifiable Position 26 | ACS Synthetic Biology pubs.acs.org/doi/full/10....

A heme-dependent enzyme forms the hydrazine in the antibiotic negamycin www.nature.com/articles/s41...

thx @shyznogd.bsky.social for posting 🙏 I immediately joined the virtual strawberry party (couldn't jump straight to madrid, unfortunately)

New @science.org An innovative way to deliver drugs to the gut at low doses to suppress inflammation www.science.org/doi/10.1126/...

Nature research paper: A polyene macrolide targeting phospholipids in the fungal cell membrane ttps://www.nature.com/articles/s41586-025-08678-9

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome https://go.nature.com/4iECjJz

Thanks to the KR-FR STARS grant, we could meet up with each other in Paris and Seoul in 2023, which brought us to the others of each one's local socities (KSP and AFERP). Congratulations everyone, especially Sarah, @mehdibeni.bsky.social and @adafede.bsky.social 🎉

It was so fun to be a part of this project. Updating MIADB, we also retrieved MS/MS spectral features specific to each MIA subclasses, which can be applied to MassQL for subclass-level annotation.

It is with tremendous emotion that I share with you our recent work @jcheminf.bsky.social rb.gy/gynwlf that resulted in the update of the MIADB and the generation of valuable spectrometric signatures that could be used as #MassQL queries 🙏 S. Szwarc @univparissaclay.bsky.social @adafede.bsky.social

#CNRSfellows 🚩 Neuf nouvelles figures prestigieuses rejoignent le programme "fellows-ambassadeurs" du CNRS. Ces chercheurs s'engagent pour trois ans au service de la recherche française 🇫🇷🔬

🔓Check out this #OpenAccess review by Lindsay Caesar & co. at @unm.edu & James Madison University, part of our Emerging Investigators collection, on natural product discovery from microbial communities in caves & underground mines #natprod #microsky Read in full here🔽

Pleased to share our new paper out in 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘊𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯 led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫 🧵 1/6 www.jci.org/articles/vie...

Machine Learning-Based Bioactivity Classification of Natural Products Using LC-MS/MS Metabolomics | Journal of Natural Products pubs.acs.org/doi/10.1021/...

Rationally minimizing natural product libraries using mass spectrometry | mSystems journals.asm.org/doi/10.1128/...

Toward an integrated omics approach for plant biosynthetic pathway discovery in the age of AI: Trends in Biochemical Sciences www.cell.com/trends/bioch...

Machine Learning-Based Bioactivity Classification of Natural Products Using LC-MS/MS Metabolomics #JNatProd pubs.acs.org/doi/10.1021/...

Although a little different from my #DREAMOLECULES, excited to share our recent group's work on the discovery of otitiglycomycins A and B, Glycolipids from Nocardia otitidiscavarum with Zika Virus Antiviral Activity @icsnlab.bsky.social @univparissaclay.bsky.social pubs.acs.org/doi/full/10....

Happy to announce the beta release of #BiGSCAPE2! This is the result of a great effort by Arjan Draisma, Catarina Loureiro and Nico Louwen, who worked tirelessly to improve the code from the ground up! Also major kudos to @marnixmedema.bsky.social for his leadership 💪 github.com/medema-group...

Google said its quantum computer needed less than five minutes to perform a mathematical calculation that one of the world’s most powerful supercomputers could not complete in 10 septillion years, a length of time that exceeds the age of the known universe. nyti.ms/3DaZFH5

Great news: ICSN lab is now on Bluesky !

Janevska @slavi-jan.bsky.social et al engineered an Aspergillus nidulans chassis for psilocybin production by repressing L-tryptophan catabolism. Deleting aminotransferase genes aroH1 and aroH2 led to a 10-fold increase in psilocybin yield. Read ➡️ https://buff.ly/4g8VutI

Title: Engineered and total biosynthesis of fungal specialized metabolites Article link: www.nature.com/articles/s41...

Check out our first foray into the fascinating world of isosteroidal alkaloids, arguably one of Nature’s most diverse natural product family: chemrxiv.org/engage/chemr...

A generative artificial intelligence approach for antibiotic optimization https://www.biorxiv.org/content/10.1101/2024.11.27.625757v1

Very happy to introduce MS2DECIDE, a decision theory-based cheminformatics tools for NP prioritization from multiannotated MS/MS data. Have a look at our preprint @ChemRxiv rb.gy/1qn6c6 @LAMSADEDauphine @Paris_Dauphine @BioCIS @UnivParisSaclay @cnrs.bsky.social

Title: Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites pubs.rsc.org/en/content/a...

Learn all about the latest developments in NP-MRD: The Natural Products Magnetic Resonance Database (NP-MRD) for 2025 #NMR #NMRchat academic.oup.com/nar/article/...

The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture pubs.rsc.org/en/content/a...

New drug discovery and development from natural products: Advances and... www.sciencedirect.com/science/arti...

This will me my fist blueet! Microbial N-Acyl lipids have been shown to regulate glucose, pain etc among other things. Therefore Helena, Vincent and Martijn asked the question - are there more and if so what types? And boy did they find some www.biorxiv.org/content/10.1...

Very excited to share with you the discovery of trirosaline, our recent #DREAMOLECULE. We used a Combination of Machine Learning and Empirical NMR Computation @JOC_OL @SzwarcSarah @ElKalamouni @miacyc_anr @UnivParisSaclay @BioCIS @ICSN_lab pubs.acs.org/doi/10.1021/...