Interested in natural products? We just published an article on hybrid peptide-polyketide-specialized lipids and describe the chitinimines, a new family of amphiphilic metabolites. Read it open access in JACS Au: doi.org/10.1021/jacs...

Interested in tailoring enzymes? Meet MITE - the Minimum Information about a Tailoring Enzyme Database (mite.lisc.univie.ac.at), capturing the substrate- and reaction-specificity of enzymes in natural product biosynthesis. MITE has just passed a milestone: the 400th MITE entry has been added!

Are you correlating natural product #metabolomics and bioactivity data? Annoyed by the lack of tools that also integrate #antiSMASH results? Meet #FERMO, our metabolomics data analysis webtool (fermo.bioinformatics.nl), now finally published in ACS Meas Sci Au doi.org/10.1021/acsm...

Are you correlating natural product #metabolomics and bioactivity data? Annoyed by the lack of tools that also integrate #antiSMASH results? Meet #FERMO, our metabolomics data analysis webtool (fermo.bioinformatics.nl), now finally published in ACS Meas Sci Au doi.org/10.1021/acsm...

After a short hiatus from social media, I am back with some exciting news: I have recently been appointed assistant professor for Natural Product Research at the University of Vienna and have started my own research group: ZdoucLab.org!

@skepteis.bsky.social 🥲

Great to see it finally published! I've tried it during beta testing and it works great! Users of v1 will feel at home right away!

Now out in @natcomms.nature.com : versions 2.0 of both BiG-SCAPE and BiG-SLiCE! With significant speed and accuracy increases, as well as new interactive functionalities. Read the full paper here #openaccess: www.nature.com/articles/s41...

The MIBiG 5.0 Annotathon is coming soon, and registration is now open! 🧬 Does your research involve biosynthetic gene clusters? Do you love natural product biosynthesis? Do you have an interest in rare & exotic enzymes? We can use your help & expertise. Register here 👉 forms.gle/C1cWcLHtrjT2...

Make sure to join us in the MIBiG Annotathons! The MITE database (mite.bioinformatics.nl) will join the efforts! If you are interested in tailoring enzymes/maturases, make sure to join us!

Marine #sponges are generally considered biosynthetic "hotspots" (e.g. Theonella) - but does this always hold true? In our newest study led by @stephenjackson.bsky.social we are looking at Inflatella pellicula's biosynthetic capacity - and our results are surprising doi.org/10.1099/mgen...

Marine #sponges are generally considered biosynthetic "hotspots" (e.g. Theonella) - but does this always hold true? In our newest study led by @stephenjackson.bsky.social we are looking at Inflatella pellicula's biosynthetic capacity - and our results are surprising doi.org/10.1099/mgen...

I am working with reaction SMARTS again and they can be really tricky in representing heterocycles! I just had a "fun" time debugging a reaction involving tryptophan - I will show you what I mean!

Awesome work with implications for chemical ecology!

Ever wondered about the funny moss growing on trees? Chances were good that you were looking at #lichen! These hybrid fungal-algae/cyanobacterial colonies are biosynthetically surprisingly diverse, as we show in our newest publication led by @garimasingh-gs.bsky.social doi.org/10.1099/mgen... (1/5)

Have you ever used a #bioinformatics #database and were frustrated by its lack of coverage? Did you ever think about starting your own resource? We just published a new strategy for community-driven #biocuration, based on our experiences with the #MIBiG database (1/8)! doi.org/10.1093/bib/...

Congratulations to this great work, happy to have contributed a little bit :)

Working on tailoring enzymes and want to learn more about the MITE database? We are organizing a hands-on training session on how use the DB and create new entries: October 30th and November 4th 10-11 am Amsterdam time. Sign up here: forms.gle/KHPqe9XV1RRg... See you there! #secmet #natprod

Interested in Python programming and good software engineering practices? Check out my newest blog post where I introduce a "modern Python" GitHub repository template and talk about my motivation for its creation! mmzdouc.github.io/posts/2025/1...

Are you building applications using docker? In my recent blog post, I am investigating git's curious behavior when used as a subprocess inside a containerized Flask application. You can read more here: mmzdouc.github.io/posts/2025/1...

Great to see PhyloNaP out! Great tool, and it also connects to mite.bioinformatic.nl! #openscience #collaboration

Aaand it's out! Meet MITE - the natural product tailoring enzyme database, just published in @narjournal.bsky.social! MITE DB captures the substrate- and reaction-specificity of tailoring enzymes, allowing to capture this information in a human- and machine-readable way! doi.org/10.1093/nar/...

Next at @vaam-microbes.bsky.social Workshop, Leo Dumjahn talks about the opportunistic pathogen Chromobacterium haemolyticum and the cyclic lipopeptides it uses as virulence factors.

Next at the @vaam-microbes.bsky.social Workshop, Valerie Rebhahn is talking about the cyanobacterial aetokthonotoxin and its mode of action in uncoupling the oxidative phosphorylation in mitochondria.

In today's third talk at @vaam-microbes.bsky.social Workshop at @freieuniversitaet.bsky.social, Nico Brüssow talks about the lanthipeptide II RiPP nostolanthin A which apparently oligomerizes - a very unusual property in RiPPs.

Next at VAAM Workshop at @freieuniversitaet.bsky.social , Alexandra Eckart from HIPS talking about her discoveries of tenacious bacteria isolated from Hydractinia echinata hydroids.

@mitjare.bsky.social kicking off the second day of the VAAM Workshop at @freieuniversitaet.bsky.social talking about the phyllosphere, its bacterial inhabitants and the natural products they produce - including surfactants!

If you are interested, make sure to apply! I have been working with Marnix, Justin, and Daniel over the last few years and they are awesome!

We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products. Apply here: www.wur.nl/en/vacancy/p... Please share!

Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)

Great to see it out @georgelund.bsky.social! Congrats!

We have an opening for a 4-year postdoc position to study the #rhizosphere #microbiome in @utrechtuniversity.bsky.social @w-u-r.bsky.social, joint project with @marnixmedema.bsky.social in the context of MiCRop. Please tag/forward this to potential candidates and/or repost: www.uu.nl/en/organisat...

Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...