Researchers at the University of Galway have revealed the results of a world-first study into how bowel cancer shuts down the immune system, and how this can be reversed to improve treatment. 🧬 Read more 👉 https://jitc.bmj.com/lookup/doi/10.1136/jitc-2025-012491

Abstract drop - CT269 - First-in-human trial in patients with metastatic colorectal cancer using CRISPR-engineered tumor infiltrating lymphocytes in which the intracellular immune checkpoint CISH is inhibited #AACR25 eppro02.ativ.me/appinfo.php?... #AACR25

Thrilled to have secured Breakthrough Therapy Designation. This will accelerate our ability to bring #CARTcells to more children with #DIPG and brain & spinal cord tumors.

Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩

With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝

Our latest story on the impact of the Sia/Siglec axis and stromal cells in colorectal cancer is online - led by Aoise O’Neill. We identified tgat stromal sualylation shaoes innate immune phenotypes and function. www.biorxiv.org/content/10.1...

Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...

@uniofgalway.bsky.social researcher helps the body help itself in the fight against cancer. @aideenryan.bsky.social is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers. tinyurl.com/3x44aa8p

University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers.

Failure is always in the background of any creative project; when the experiments are not working or the results don’t seem to make sense. But for discovery, you can’t deny yourself the permission to fail, and we should better teach failure in all its glory.

Grant has been reimagined, rewritten, read by others, revised and submitted! Fingers crossed that it does well. On to the next challenge we go, Sisyphus! I get knocked down, I get back up again! 💪🏽

Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS. Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐 #SABCS24 @oncoalert.bsky.social @sabcs.bsky.social

#Bridge2024 coming to a close! Saturday, December 7th 2024 @2:10 pm and we are entering the last session/will cover 1st line #immunotherapy, salvage, igniting change in #cancer #vaccine development, combo IO, #PD1 refractory & more @sitcancer.bsky.social #MSD #BIOTECH #BMS #Merck #Regeneron #UbiVac

WORK HARD, PLAY HARD! Celebrate your success & commiserate over failures / #Immunotherapy #Bridge2024 is over & the 15th #Melanoma Bridge has started. Great being in #Napoli with so many friends. PAscierto, Choueiri, Hamid, Tawbi @samirkhleif.bsky.social , Bruno, Guerrero, @sitcancer.bsky.social

Discussion of Prof Mitch Levesque data / Amazing single cell #melanoma phenotypes/ can it explain resistance? Thinks metabolic signature? Functional data more important #Bridge2024 @melanomaresearch.bsky.social @impactmelanoma.bsky.social @sitcancer.bsky.social #FinishCancer #PAscierto

Prof Michael Postow #melanoma #immunotherapy Expert @mskcancercenter.bsky.social talks #neoadjuvant treatment.. How many doses of checkpoint blockade? Can we reduce toxicity & maintain efficacy? @sitcancer.bsky.social #Bridge2024 @impactmelanoma.bsky.social @melanomaresearch.bsky.social

More video! Here's my conversation with Nobel-prize winner Katalin Kariko, who pioneered mRNA vaccines. youtu.be/5_9ccDmX3hs?...

Congratulations Sid, Courtney and @drpipdunne.bsky.social on your publication in Scientific Reports- a really useful resource to help the field ensure more robust discovery approach using dualGSEA. @researchireland.bsky.social @universityofgalway.bsky.social www.nature.com/articles/s41...

We have a great line up and we are super excited by all the abstracts we have recieved! Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0

💥40 years ago today a 33 y/o dying of #metastatic #melanoma got #LAK & #IL-2 & all #cancer went away! Dr. S.A. #Rosenberg (SAR) had the #immune system #cure a patient/I was in SAR’s lab 85-90/incredible era & energy/Great story in @usatoday.com apple.news/AIcm-M7cDQ-O... @sitcancer.bsky.social

Delighted to celebrate Eileen’s, Aoife’s and Jiemen’s graduations yesterday. Three stellar PhD students who were a pleasure to supervise and work with. Wishing them all of the best in their future careers. @researchireland.bsky.social

Only a subset of patients respond to immunotherapy Why? Which ones? We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response. www.nature.com/articles/s41...

Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment www.cell.com/cell-reports...

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

Great article w/ CÚRAM FI Sharon Glynn at Universityof Galway in TechCentral this week explaining her work on breast cancer and triple negative breast cancer in particular.. Read more at techcentral.ie/focus-on-res... #breastcancerresearch #NOCANCERNETWORK @researchireland.bsky.social

The hallmarks of cancer immune evasion

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature 🧪 www.nature.com/articles/s41...

Interesting role for PGE2 - EP2/4 axis in immunosuppression in tumours www.nature.com/articles/s41...

Last of the summer tomatoes! Made soup and crusty bread. The simple pleasures!