New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

When we encounter the same reward repeatedly, we show variable responses; is this just noise? In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺 W/ @akuehnel.bsky.social www.medrxiv.org/content/10.1...

2 Lecturer (Assistant Prof) positions available @yorkpsychology.bsky.social! Come join our department! #neuroskyence #cognition #psychscisky #neurojobs jobs.york.ac.uk/vacancy/lect...

Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇

the tldr of my thread is that, interoceptive sensing at rest has no relationship to mental health symptoms, and we think this is likely because we need to measure interoception during and after arousal, close in time to symptoms, with ecological measures.

Hey, it's out! doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:

Modern theories of emotion (especially “interoceptive inference”) often cite William James as a key inspiration. But what did James actually say about emotion, and is it supported by the data? Here’s a brief look at the core arguments and classic evidence. 🧵

Gut microbiome is associated with insula structure in neonates www.sciencedirect.com/science/arti...

First go at expansion microscopy (bar the one time we accidentally washed the tissue down the sink...) and look at that neuron!😍

How nerve cells transfer their powerhouse mitochondria to fuel cancer cells @nature.com www.nature.com/articles/d41... www.nature.com/articles/s41...

Still a week to go to apply for our open position in Mammalian Neuroscience at University of Warwick!

We created a photometry python package for unbiased standardised post-hoc analysis using bootstrapping confidence intervals No more AUC or time bins analysis! Ever Follow our simple step by step instructions. @foldi.bsky.social @philjrdb.bsky.social www.biorxiv.org/content/10.1...

Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n

New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!

Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩‍🔬👨‍🔬 My department is hiring! Closing on June 30th. Please repost widely! www.jobs.ac.uk/job/DNK944/a...

Here in the School of Biological & Behavioural Sciences at QMUL we are seeking to appoint a Teaching Fellow in #Bioinformatics. Please spread the word and encourage applications from suitable candidates. Deadline for applications is June 4th. qmul-jobs.tal.net/vx/appcentre...

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”

Microglia are often framed as driving maladaptive behavior in stress and depression, but what if they're important for treatment as well? In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine. www.biorxiv.org/content/10.1...

Brain/behaviour people - come to beautiful Scotland - we are recruiting in psychology and neuroscience across all grades! Closes May 12. Details below, and please re-post 🙏 www.nature.com/naturecareer... More about us here: www.gla.ac.uk/schools/psyc... #neuroskyence #neurojobs

These are not good news for us foreigners who are (or plan to be) co-PI an NIH grants @altnih4science.bsky.social. Anybody who knows whether they plan to terminate ongoing R01 grants? www.nature.com/articles/d41...

www.nature.com/articles/s42... GIP is such a strange hormone. I'm glad these two companion papers can shed some light on the mystery...

www.nature.com/articles/s42... Anyone else find GIP super confusing - but in an exciting way?

Join us at British Library on-line or in person Fri 9th May 7pm to hear me @zoesqwilliams.bsky.social @kimberleywilson.bsky.social @christinaavogel.bsky.social discuss GLP-1 based therapies for obesity 🥗🍰. Tickets via: events.bl.uk/events/ozemp... @imperialbrains.bsky.social @imperialmed.bsky.social

Very very cool and lovely anatomical work! I wonder if this is at all modulated by GLP1? GLP1 neurons are activated by IL6 and sit in the nearby NTS. Excited to give this a thorough read!

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

ARE YOU AN ECR? Apply for the Julia Buckingham Award The award recognises the achievement and potential of up-and-coming scientists. You get: 🔬 15 minute lecture 💸 £375 prize money 🧡 1-year membership to the BSN Apply by 31 May 2025: www.neuroendo.org.uk...

Do you get in a bad mood if you are hungry? Over 4 weeks with EMA+CGM, we tested if mood shifts are subconsciously driven by glucose levels or ratings of metabolic state #neuroskyence 🩺 Work w/ @kristinkaduk.bsky.social @akuehnel.bsky.social @derntllab.bsky.social www.biorxiv.org/content/10.1...

How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later? Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala. 📄: nature.com/articles/s41...

Hello Bluesky! Our students are running a short survey on interoception, ADHD, and autism. If you’ve got a few minutes, they’d be so grateful if you could take part — and help spread the word! 🔗 docs.google.com/forms/d/e/1F... #psychscisky

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12

🚨We're hiring another tenure-track at McGill University: focus on brain-body science! 👇 mcgill.wd3.myworkdayjobs.com/en-US/mcgill...

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @nature.com www.nature.com/articles/d41... nature.com/articles/s41...

It will always amuse me that modern researchers working on "interoceptive predictive coding" have totally ignored the entire historical body of work (cerca 1960s-1970s) on interoceptive conditioning.

Very cool! www.nature.com/articles/s41...

Science papers in 1965: here is a hand drawn plot of some heart rate data from 7 people I thought looked interesting Science papers now: here are 65 different plots spanning multiple forms of intervention, imaging, machine learning, and model systems

Fascinated by brain circuits? Looking for a postdoc position? We are a looking for an experimentalist to join us to investigate the neural substrate underlying goal-directed habitual strategies in visual tasks. Spread the word! Apply by 1st of April - no joke!

This is interesting and aligns with my own experience of having a partner who's an imaging specialist at the same uni. He's an amazing collaborator at work, does more than half the domestic stuff and took substantial leave after our daughter was born. Academia ain't all bad if you do it together.

Join SSIB Today! 📅 Annual Meeting Deadlines: Abstracts: March 21 (Today) Early Registration: June 18 📷 Learn more: ssib.org/2025/ Join a supportive and innovative community. Learn more from #KathleenKeller, President Elect (2025), President (2026), below!

#Brain #vasculature #researchers: what perfusion systems do you recommend for mice? Thank you!

Editors will often ask preclinical scientist for human data and scientists working in other areas for animal experiments @nature www.nature.com/articles/d41...

This is super interesting and so elegant! And perhaps aligns really well with the idea that the afferent vagus nerve is organised according to multiple modalities (target organ, tissue layer and stimulus type) as proposed by Zhao et al. 2022 www.nature.com/articles/s41...?

Can we enhance interoception by controlling the heart? Thrilled to share our new study, led by @ashleytyrer.bsky.social , where we use computational modeling to show that blockading peripheral noradrenaline uniquely alters awareness of heart rate & breathing! www.biorxiv.org/content/10.1... 🧵👇

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...

Excellent environment, excellent mentor, excellent science - what more could you want from a postdoc position?

We have a 3-year postdoctoral and a research assistant position available to join our team here in Manchester! Please get in touch if interested OR pass on! PDRA: www.jobs.manchester.ac.uk/Job/JobDetai... RA: www.jobs.manchester.ac.uk/Job/JobDetai...

New paper alert! Glad to be be part of this study in Science, led by Eleanor Raffan, University of Cambridge #obesityisnotachoice www.science.org/doi/10.1126/...

Join SSIB Today! 📅 Annual Meeting Deadlines: Abstracts: March 14 Early Registration: June 18 📷 Learn more: ssib.org/2025/ Join a supportive and innovative community. Learn more from #ThomasLutz, former president (2011-12), below! #IngestiveBehavior