Excited to see our review on #VEXAS now out in @thelancet.com A collaborative effort from our amazing NIAMS and NHLBI VEXAS team Bhavisha Patel, Peter Grayson, Alice Fike, Kaitlin Quinn, Ben Turturice www.sciencedirect.com/science/arti...

Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...

Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...

I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy. A great collaboration with NIH. www.nature.com/articles/s41...

Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...

Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young

Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...

The NIH goslings making an appearance this spring 🌸🪿

New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...

In a new editorial, Dr. Mary Frances McMullin explores the scientific foundations and clinical implications of a study on variant EPO and erythrocytosis. Read the editorial: nej.md/3YmAnNU @qubelfastofficial.bsky.social #MedSky #Hematology

Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu #MedSky #Hematology

Happy birthday to the OG NHLBI #BMFsm team! Dr. Neal S Young, staff scientist Dr. Sachiko Kajigaya and research nurse Olga Rios who have spent the last few decades at the NIH driving a clinical and translational research program which has led to astonishing progress in #SAA and other marrow failures

Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...

Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...

Looking for public comments on the @ash.hematology.org #AplasticAnemia guidelines - see here! www.hematology.org/education/cl...

Unfortunately was not able to travel to EBMT but our poster can still be viewed virtually! We report on the first 7 #VEXAS patients who underwent allo-HCT on our prospective phase II trial. High rates of #GVHD and other inflammatory complications noted. @ Bhavisha Patel

Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients @nejm.org evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.1...

Excited to see our NHLBI work just published in @bloodadvances.bsky.social showing the negative effects of HLA alloimmunization in #SAA patients treated with immunosuppression. Lead by our former fellow Jibran Durrani now at UMiami ashpublications.org/bloodadvance... #BMFsm

Congrats to our former NHLBI @petermaccc.bsky.social fellow Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA

The #CCCTAA at #ASH24. Look for important international collaborative studies on #telomere biology disorders in the near future. @teamtelomere.bsky.social is a key partner. Reach out to join the Clinical Care Consortium of Telomere Associated Ailments 🧬 #teamscience

Happy Christmas to all from Ireland! 🇮🇪 🎄

Congrats to @jamesnolan.bsky.social (now at @pmresearch-uhn.bsky.social) on his #ASH24 abstract achievement award for his PhD research @tcddublin.bsky.social! @adrianbracken.bsky.social 🇮🇪🇨🇦 @ash-hematology.bsky.social #Lmsm #ASHKudos

Beautiful view from the conference center at #ASH24 @ash-hematology.bsky.social 🌅

Congrats to Denis O’Keeffe from UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social

Congrats to NHLBI‘s John Tisdale for winning the @ash-hematology.bsky.social #ASH24 Beutler Prize! #SCD #ASHKudos

Former NHLBI fellow Jibran Durrani (now @miamirosenstiel.bsky.social) presenting our group’s work on complement mediated immune activation in #SAA with HLA alloimmunisation. #ASH24 @ash-hematology.bsky.social

Check out my NHLBI colleague Bhavisha Patel‘s poster reporting our work in patient reported outcomes in #VEXAS. Patients reported high symptom burden. #ASH24 @ash-hematology.bsky.social

Very nice talk from Yael Kusne from Mayo Clinic on the the increased incidence of lymphoid and solid malignancies in patients with #DDX41 #IBMFS #BMFsm #ASH24 @ash-hematology.bsky.social

Amazing talk from our NHLBI fellow Nick Lee presenting long-term results from our high-dose Danazol protocol for patients with #TBD. #ASH24 @ash-hematology.bsky.social

Check out our former NHLBI fellow (now at @miamirosenstiel.bsky.social!) JibranDurrani’s #ASH24 poster looking at more selective JAKi in our immune BMF model. @ash-hematology.bsky.social #BMFsm

Top original posters here on BlueSky: @drmiguelperales.bsky.social | @drdavidjyoung.bsky.social | shematologist.bsky.social | @anand-88-patel.bsky.social | theblooddoc.bsky.social | jamesfanwu.bsky.social | rubenmesamd.bsky.social | jmaakaron.bsky.social | emmamgroarke.bsky.social #ASH24 3/3

Meeting with my Irish 🇮🇪 contingent at #ASH24! @ash-hematology.bsky.social Nina Orfali and Paul Browne

Zoe McQuilten from Monash 🇦🇺presenting the final results of the Diaamond-AVA-first looking at hATG, CSA, and avatromboag. Similar results to eltrombopag seen. #ASH24 @ash-hematology.bsky.social

Final results of the EBMT RACE study randomizing hATG/CSA/EPAG v IST alone. Promising long-term data! @ash-hematology.bsky.social #ASH24 #BMFsm

Interesting data from King’s College London looking at autologous Treg cells in #AA - persistent st 6 months with responses in some patients. #ASH24 @ash-hematology.bsky.social

Interesting talk from Olivier Hermine from Necker, Paris looking at the mechanisms underlying erythroblastopenia in #VEXAS - possible role of defects in ubiquitination and ribosomes. #ASH24 @ash-hematology.bsky.social

Excellent talk from colleague Zhijie Wu who presented our lab’s data on T-cell clonality and dynamics after IST in #SAA. #ASH24 @ash-hematology.bsky.social #BMFsm

Very interesting talk from Carlos Bravo-Perez looking at the relevance of variants in thrombotic / complement related genes in #PNH. #ASH24 @ash-hematology.bsky.social

Very nice talk from Austin Kulasekararaj from King’s College London on #ClonalHematopoiesis from the the EBMT RACE trial. #BMFsm #ASH24 @ash-hematology.bsky.social

Amazing talk from Fernanda Gutierrez-Rodrigues showing our lab’s work on #ClonalHematopoiesis over 10+ years after IST. We saw long-term clonal persistence of ASXL1 and PIGA. #ASH24 @ash-hematology.bsky.social

An exciting #BMFsm oral session now starting in Room 11! Moderated by Bhavisha Patel and Antonio Risitano. #ASH24 @ash-hematology.bsky.social Everyone stop by!

Shameless shoutout to the #RUNX1 Natural History Program of NHGRI as presented by Erica Bresciani. It’s my absolute pleasure to be a part of the program bringing together amazing patients and collaborators to study #RUNX1FPD #ASH24

Saving the best (but I “may” be biased) for last in #ASH24 germline workshop - Dr. Maryam Rafati from #NCI_ClinicalGenetics presenting on heterozygous #DNA repair gene variants & #HCT outcomes. MUTYH carriers had poorer outcomes if received #TBI Collab w/ #CIBMTR

Obligatory #ASH24 sign photograph! Are Fernanda and I blood 🩸 themed or Christmas 🎄 themed or both? #fASHion @ash-hematology.bsky.social

Provisional results at @ash-hematology.bsky.social from the the NCI clinical trial using RIC #HCT with briquilimab (anti CD117) for patients with #GATA2. #BMFsm @sung-yun-pai.bsky.social Dani Arnold #ASH24

The Scientific Workshop on Germline Predisposition to Hematopoietic Malignancies and Bone Marrow Failure is always must-see cutting edge science in understanding the interface of marrow disease and malignancy #ASH24 #HemeSky #BMFS

The scientific workshop on germline predisposition to hematologic malignancy and BMF is starting! Looks to be an exciting session with specific emphasis on #RUNX1 and #DDX41 @ash-hematology.bsky.social #ASH24

The most impressive ribbon trail I have seen so far belongs to NHLBI’s Cindy Dunbar! #ASH24 @ash-hematology.bsky.social

Opening session of #ASH24 - the IPIG #PNH group. My colleague Fernanda Gutierrez-Rodrigues received the IPIG ASH abstract award! Check out her presentation at the #BMFsm oral session tomorrow morning. @ash-hematology.bsky.social

A very interesting #ASH24 detour to see the sea lions at La Jolla! @drdavidjyoung.bsky.social @ash-hematology.bsky.social