Smart! Raven loves winning Tic Tac Toe.

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini...

FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN www.cnn.com/2025/07/...

What's the optimal number of steps of physical activity this is associated with multiple (9) favorable outcomes? The largest, systematic review of 57 studies, 35 cohorts. 7,000 steps is clinically meaningful, benefit also seen for 4,000 steps cf 2,000 steps thelancet.com/journals/lan...

I seriously think the Social Internet is 21st century cigarettes. Complete with secondary smoke causing a lot of harm in nonusers.

This fits with my theories here of dementia being a multiple hit hypothesis and structural changes over a decade before lay the groundwork for brain failure in the setting of cognitive/systemic stressors.

Amazing thread. Trump has shown us on countless occasions that he has no shame. It’s more troublesome that there are enough like minded individuals he has surrounded himself with to propagate this metastatic hate.

“A society grows great when old men plant trees whose shade they know they shall never sit in.” — Greek proverb

Timeline cleanser

Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function www.science.org/doi/10.1126/...

Read our full statement calling on Sec. Kennedy to stop spreading harmful Alzheimer’s myths: bit.ly/43dRIKw. 4/4

🔥 Most important paper I've read all year🔥 👉 Injury/disease doesn't reliably predict pain 👉 Biomarkers alone can't explain pain 👉 PSYCHOSOCIAL factors reliably determine chronic pain 👉 Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors www.nature.com/articles/s41...

I just really need everybody to understand that everything that’s happening in and to the global economy now (and all the businesses and people in it) is the entirely predictable result of the intentional decisions of one guy who doesn’t understand how the global economy works.

Nightmare fuel

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social

Catch probability? You wouldn’t believe me.

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

Almost every line of this story would have been simply unbelievable a few months ago: —Pioneering cancer researcher; —*Arrested* at airport in Boston; —Now indefinite ICE detention in Louisiana; —"Crime": not declaring some frog-embryo samples for research. Read it. www.nbcnews.com/news/us-news...

Personally, I think it should be front page news for at least a month if a sitting US President is using falsified evidence to try and deny due process to a man who has committed no crime, but that’s just me

We've seen videos like this before, but usually when you see a tearful wife pleading with the kidnappers who have taken her husband, she's not talking to the U.S. president

“Inside that tiny speck is an entire architecture like an exquisite forest..." 🧠❤️ #neuroskyence www.theguardian.com/science/2025...

Lifestyle matters!! KU has put together our LEAP (Lifestyle Enrichment for Alzheimer’s Prevention) www.kumc.edu/research/alz...

The Fourth Circuit is famously succinct. storage.courtlistener.com/recap/gov.us...

#corgi focus

The penguins are globalists and rich liberal elitists. Just look how they’re dressed.

New @science.org Hedonic eating (eating for pleasure, not need) is mediated by dopamine neurons (in the brain ventral segmental area, VTA) and they are antagonized by GLP-1 drugs, such as semaglutide, leading to weight loss www.science.org/doi/10.1126/...

Shouting it from the mountain tops:

A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social ! uknow.uky.edu/research/fue...

Researchers found 14 of the 20 amino acids essential for life on Earth in samples from the ancient asteroid Bennu.

Now is as good a time as any to remind everyone that the Negro Leagues Baseball Museum in Kansas City (@NLBMuseumKC) exists to tell a deeply important American story -- one that is ultimately about triumph. Our history, good and bad, is all we have. Learning it is our duty.

Elon Musk as Wile E Coyote running into an ACME wall is too on the nose

On the cyclic benefits of intermittent fasting and metabolic switching, this is an outstanding new perspective @naturemetabolism.bsky.social www.nature.com/articles/s42...

*Screams into the void*

About fifty years ago, NASA strapped a message in a bottle to a rocket and flung it into the deep dark It wasn’t supposed to go this far, but it did. Long past its mission, it’s still out there so far away now that a simple hello takes a day to reach it, and another day to hear if it says hello back

Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world. Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...

Found some waste…

Such amazing research! Very cool. When I got to this “imagine” part though I said “oh no” Hopefully you didn’t enroll anyone with significant aphantasia 👀

A doctor has been serving one of Baltimore’s poorest neighborhoods for decades — and if his patients can’t pay, that’s OK with him. So when he was diagnosed with cancer, his community rallied to raise $100,000 for his treatments.

Guess who just got back from the groomers and have very fetch bandanas 🍀 #corgi #eskie

Great thread

The real life consequences of unscientific propaganda

So Def. Sec Hegseth changed the name of Ft Moore back to Ft Benning. As w/ Ft Bragg, they found another soldier with the same name to make it seem like they weren't just changing the name back to honor a Confederate. But you should know who Ft Moore was named for. 🧵 www.defense.gov/News/Release...

Missouri has been running the pilot for Project 2025 for a couple of decades. With a GOP Supermajority, over 30% of our schools are on a four-day week. We fund vouchers for private religious schools. Our starting teachers are 50th in the nation for pay and they pay for their own supplies.

Senator Marshall, what are you so afraid of?

I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org

Ending the night with this. *Get your hankies* A D-Day veteran called a gracious and humbled Zelenskyy a hero.

Just read this graf. Share it with people you know who don’t pay attention to politics or news.

Colorado's Rep Brittany Pettersen (D) flew cross-country with her one-month-old to vote against the GOP budget tonight. Dems ended up one vote short. Pettersen was part of an unsuccessful bipartisan push to allow new mothers to vote remotely. #copolitics