Claudia Alvarez Carreño
@claudiaalcar.bsky.social
📤 866
📥 521
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Protein structure evolution | Royal Society Newton International Fellow at UCL | she/her
pinned post!
Thrilled to introduce TEDLH, a library of profile HMMs built from TED’s structure-derived domain annotations of the AFDB. Explore 765K HMMs capturing CATH superfamily diversity.
www.biorxiv.org/content/10.6...
add a skeleton here at some point
4 months ago
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20 days ago
🚨 Good news! Abstract deadline Extended! 🚨 Don’t miss your chance to be part of the meeting. Submit your abstract by May 15th, 2026. Meet our invited speakers, share your research, and connect with the community. ✨
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NASA Artemis
23 days ago
"Planet Earth: You. Are. A. Crew." Artemis II mission specialist Christina Koch reflects on what it means to be a "crew."
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Protein Structure Evolution (ProSE) Seminar
27 days ago
Our next speaker will be Timothy Fuqua
@timothyfuqua.bsky.social
with "The Evolution and Emergence of Regulatory DNA", 14th April, 5PM CET. Sign-up here:
tinyurl.com/prose-seminar2
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Zachary Ardern
about 1 month ago
My new mini article exploring recent developments using the phylogeny of genomes to improve data compression and the computational efficiency of some key tasks in genomics 🧬
rdcu.be/faKgm
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ISCB News
about 1 month ago
🇵🇪 Tutorial proposals are open for
#LATAM2026!
We're seeking hands-on tutorials in cutting-edge
#bioinformatics
topics. Help attendees build knowledge, learn new research areas, or develop advanced skills. 📅Deadline: May 13 Submit here:
https://www.iscb.org/latam2026/call-for-submissions/tutorials
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Klara Hlouchova lab
about 1 month ago
To all early life enthusiasts🦠 How did we get from soups of chemicals to the Last Universal Common Ancestor? 🌋 Help us bridge the gap at A Road to LUCA in beautiful Prague! 🇨🇿 ⏳ 1 WEEK until the abstract deadline! Explore here:
natur.cuni.cz/en/aroadtoluca
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JME: A Road to LUCA
With support from Journal of Molecular Evolution and its editorial board, we are proud to organize “ JME: A Road to LUCA - Filling the gap between prebiotic chemistry and life as we know it ”, our ...
https://natur.cuni.cz/en/aroadtoluca
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MPI for Biology Tübingen & Friedrich Miescher Laboratory
about 1 month ago
DSSS continues this Thursday with speaker Dr. Benjamin Podbilewicz who has thankfully managed to join us from Technion in Haifa, Israel. Everyone welcome! ▶️More info:
tinyurl.com/27cedwft
📆: Thursday 26th March at 11am 📍: MP-Intelligent Systems seminar room, ground floor
#DSSS
#MP-IS
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Timothy Fuqua
about 2 months ago
ERC starting grant eligibility window increased to 10 years post-PhD defense:
www.ukro.ac.uk/news/changes...
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Changes to the 2026 and 2027 ERC Work Programmes
With the upcoming ERC Work Programme 2026 this July, several changes to the submission of applications and the evaluation of proposals will apply. The main novelties for 2026 and 2027 are are summaris...
https://www.ukro.ac.uk/news/changes-to-the-2026-and-2027-erc-work-programmes/
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Society for Molecular Biology and Evolution
about 2 months ago
🧬EvolCompGen presents: Christian Landry on the Evolution of gene duplication, from redundancy to dependency
@christianlandry.bsky.social
🗓️ Join us on Monday, March 23 at 11:00 AM EDT 📌 Register here:
us02web.zoom.us/webinar/regi...
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Hassan uz Zaman
about 2 months ago
This talk is happening tomorrow—as part of the Protein Structure Evolution seminar! Click here to register if you like cool science:
tinyurl.com/prose-seminar2
Organized by
@lacholt.bsky.social
,
@caro-rocha.bsky.social
,
@claudiaalcar.bsky.social
,
@zachary-ardern.bsky.social
and myself.
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Protein Structure Evolution (ProSE) Seminar
2 months ago
Our next Talk will be "Protein Origami and the Hidden Rules of Functional Innovations"! March 11th, 5PM CET. Sign-up here:
tinyurl.com/prose-seminar2
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Zebrafish Rock!
2 months ago
Today is
#RareDiseaseDay
& we are celebrating by highlighting the invaluable work of the Undiagnosed Diseases Network (UDN)! Formed in 2020, it aims to solve the most challenging medical mysteries using advanced technologies. In this thread, we will highlight their use of the
#zebrafish
model. 1/5 🧪
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Starting in less than an hour! Register to join:
tinyurl.com/prose-seminar2
add a skeleton here at some point
3 months ago
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Ashmolean Museum, Oxford
3 months ago
If the hashtag
#SuperBowl
has you wondering where the superb owls are…we got you! 🦉Detail from Owl, 1601–1800. EA2012.344.b 🦉An owl on a branch, 1893–1898, Sir Edward Coley Burne-Jones (1833–1898). WA2015.68.29 🦉Owl, 1865, Arthur Burgess (1843–1886). WA.RS.RUD.046
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Tom Williams
3 months ago
meetings.embo.org/event/26-mic...
Announcing the 2026 EMBO course in Computational and Experimental Microbiomics, to be held at Bath. The course brings together experiments and bioinformatics to study host-microbe interactions and co-evolution. Register now, or at least by 11 May, if interested :)
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Computational and experimental microbiomics
The critical contribution of microbiota to animal, plant and environmental health is now widely accepted. Progress has been driven by two parallel approaches: in silico analyses of large -omics data …
https://meetings.embo.org/event/26-microbiomics
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Origin of Life Early-Career Network
3 months ago
Curious about how life began? OoLEN is a global community for early-career researchers in origins of life and prebiotic chemistry. 🧬🌍 Connect with others across disciplines, find opportunities, and grow together. Join:
oolen.org/join
Tell us in the replies—what do you work on?
#OriginOfLife
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Protein Structure Evolution (ProSE) Seminar
3 months ago
Next up in our ProSE seminar series: Vyacheslav Tretyachenko on alternative translation in the human proteome Register to join:
tinyurl.com/prose-seminar2
Past seminars:
tinyurl.com/ProSE-videos
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Hassan uz Zaman
3 months ago
Come one, come all to the first Protein Structure Evolution talk of the year (Feb 10)! Click here to register if you like cool science:
tinyurl.com/prose-seminar2
Jointly organized by
@lacholt.bsky.social
,
@caro-rocha.bsky.social
,
@claudiaalcar.bsky.social
,
@zachary-ardern.bsky.social
and myself.
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Klara Hlouchova lab
6 months ago
Can proteins fold and function with half of the amino acid alphabet? Using only 10 residues, we designed stable, mutation-resilient structures—no aromatics or basics involved. A minimalist foundation for ancient biology and synthetic design.
tinyurl.com/37t8br4v
#ProteinDesign
#OriginsOfLife
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Ancient amino acid sets enable stable protein folds
Early proteins likely arose from a chemically limited set of amino acids available through prebiotic chemistry, raising a central question in molecular evolution: could such primitive compositions yie...
https://tinyurl.com/37t8br4v
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Rachel Nuwer
3 months ago
With most psychedelic drugs, you never know what you're going to get. But this mysterious mushroom from China - without fail - causes users to hallucinate tiny people: crawling up walls, popping out from under furniture and marching under doors.
www.bbc.com/future/artic...
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'They saw them on their dishes when eating': The mushroom making people hallucinate dozens of tiny humans
Only recently described by science, the mysterious mushrooms are found in different parts of the world, but they give people the same exact visions.
https://www.bbc.com/future/article/20260121-the-mysterious-mushroom-that-makes-you-see-tiny-people
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Working Class History
3 months ago
#OtD
22 Jan 2018 legendary anarchist author Ursula K Le Guin died aged 88 in Portland, Oregon. An ardent feminist and advocate for diversity in literature and publishing, she won numerous awards for her work. We have made available some of her books here:
shop.workingclasshistory.com/collections/...
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Victor Tobiasson
4 months ago
FYI were starting weird structure/evolution/biology stuff at Glasgow University! If you're interested let me know! Tell your friends! CRYO
www.jobs.gla.ac.uk/job/research...
BIOINFO
www.jobs.gla.ac.uk/job/research...
TECHNICIAN
www.jobs.gla.ac.uk/job/technici...
#science
#hiring
#evolution
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Thrilled to introduce TEDLH, a library of profile HMMs built from TED’s structure-derived domain annotations of the AFDB. Explore 765K HMMs capturing CATH superfamily diversity.
www.biorxiv.org/content/10.6...
add a skeleton here at some point
4 months ago
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Stephen Royle
5 months ago
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology
#WTFology
www.biorxiv.org/content/10.6...
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The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
https://www.biorxiv.org/content/10.64898/2025.12.12.693869v1
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Protein Structure Evolution (ProSE) Seminar
6 months ago
The next ProSE Seminar will be given by Joana Pereira
@joanampereira.bsky.social
(VIB, KU Leuven) 🗓️ November 11th, 5pm CET Registration is now open:
tinyurl.com/prose-seminar2
Please share!
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Lars Eicholt
6 months ago
Join our next ProSe seminar 11th November 5PM CET and follow us
@proteinstructure.bsky.social
!
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Protein Structure Evolution (ProSE) Seminar
6 months ago
Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT. Sign-Up:
tinyurl.com/prose-seminar2
Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha, Sergio Romero Romero and Md. Hassan Uz-Zaman.
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Klaus Paschek
7 months ago
I'll be featured at the outreach event of the Science Café in Nijmegen 🇳🇱, talking about astrochemistry and the origins of life and its building blocks in space and on early Earth. Stop by if you're in the area on Thu, Oct. 23, 7.45 PM. Admission is FREE, and there will be jazz! 🎶🎷🌌🔭☄🦠
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Gonzalo Parra
6 months ago
Last week to apply to join our recently created lab as a PhD Student! Join us to research about protein computational biophysics, evolution, machine learning , and human mutations! Description and link to apply here:
www.bsc.es/join-us/job-...
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596_25_LS_ESB_R1
Reference: 596_25_LS_ESB_R1 Job title: PhD student in computational biophysics and machine learning (R1, FPI)   About BSC   The Barcelona Supercomputing Center - Centro Nacion
https://www.bsc.es/join-us/job-opportunities/59625lsesbr1
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The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU): Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t” Date: October 14th, 5 pm CET Registration link:
tinyurl.com/prose-seminar2
7 months ago
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Claudèle Lemay-St-Denis
7 months ago
How does catalysis emerge from non-catalytic domains? In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead. A striking case of catalysis evolving from binding.
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The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU): Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t” Date: October 14th, 5 pm CET Registration link:
tinyurl.com/prose-seminar2
7 months ago
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Claudia Alvarez Carreño
Nature
8 months ago
Modelling suggests that most Caribbean coral reefs will erode by the year 2100 as sea-level rise outpaces reef growth and limits potential reef restoration
go.nature.com/42229kK
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Caribbean coral reefs are threatened by rising seas
Modelling suggests that most Caribbean coral reefs will erode by the year 2100 as sea-level rise outpaces reef growth and limits potential reef restoration.
https://go.nature.com/42229kK
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Jeremy Berg
8 months ago
ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS Comment period ends September 29th
www.federalregister.gov/documents/20...
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Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media
Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...
https://www.federalregister.gov/documents/2025/08/28/2025-16554/establishing-a-fixed-time-period-of-admission-and-an-extension-of-stay-procedure-for-nonimmigrant#p-11
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Happy to share Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record 🧪 It appears as part of a Special Section in
@genomebiolevol.bsky.social
organized by
@cpuentelelievre.bsky.social
@proteinmechanic.bsky.social
and J. Douglas
doi.org/10.1093/gbe/...
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Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record
Abstract. Protein folds are structural units defined by the number, type, arrangement, and orientation of their core secondary structural elements. The uni
https://doi.org/10.1093/gbe/evaf148
8 months ago
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The ProSE seminars are back after a summer break. The next speaker is Nir Ben-Tal on "Contrastive learning unites sequence and structure in a global representation of protein space". Date: September 9 Time: 5pm CET Register here:
tinyurl.com/prose-seminar2
Please share! 🧪
#mevosky
8 months ago
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The ProSE seminars are back after a summer break. The next speaker is Nir Ben-Tal on "Contrastive learning unites sequence and structure in a global representation of protein space". Date: September 9 Time: 5pm CET Register here:
tinyurl.com/prose-seminar2
Please share! 🧪
#mevosky
8 months ago
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Genome Biology and Evolution
8 months ago
In a new GBE Review,
@cpuentelelievre.bsky.social
@proteinmechanic.bsky.social
& J. Douglas give an overview on protein structural phylogenetics, how to obtain evolutionary insights from structural data, and key applications and future directions. 🔗
doi.org/10.1093/gbe/evaf139
#genome
#evolution
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EDI Caucus
8 months ago
Help us gauge the state of the UK's research & innovation sector in terms of preventing and handling bullying & harassment. Please share our survey of anyone who has witnessed or experienced it at work.
go.hw.ac.uk/EDICa/Bullyi...
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Thrilled to see this out! Thank you for the shout out
@chercheurjuteux.com
!
add a skeleton here at some point
9 months ago
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Alexis Verger 🧬🧫🧪
9 months ago
[Resources]
#AlphaFold
protein and PPI prediction databases 1️⃣ Predictomes (genome maintenance & H2A/H2b)
predictomes.org
2️⃣ Flypredictome
www.flyrnai.org/tools/fly_pr...
3️⃣ Human interactome
prodata.swmed.edu/humanPPI
4️⃣ BFVD (viral proteins)
bfvd.steineggerlab.workers.dev
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Iain Cheeseman
10 months ago
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
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Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
https://www.biorxiv.org/content/10.1101/2025.07.22.666109v1
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Ajasja💻🧬🔬
10 months ago
Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉 Come join us for three days of protein design fun! (October 20-22, 2025) Direct registration link:
pretix.eu/SBD/RCon2025/
Website:
europeanrosettacon.org
We are looking forward to seeing you! Please share this far and wide:)
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Geo Santiago-Martínez
11 months ago
¿Te interesaría unirte a nuestro laboratorio como Postdoctoral Fellow? ¿Está interesado en investigar y contribuir a la comprensión del papel de los anaerobios en la salud humana? Revisa la convocatoria Pew Latin American Fellows ¡Contáctame si cumples con los requisitos!
#Archaea
#MicroSky
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Society for Molecular Biology and Evolution
about 1 year ago
📖 SMBE journals on Bluesky Interested in learning the latest advances in evolutionary biology, genomics, and molecular biology? Follow the SMBE sister journals MBE and GBE here on Bluesky and get updates on new articles coming out. MBE:
@molbioevol.bsky.social
GBE:
@genomebiolevol.bsky.social
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Join us for the next ProSE Seminar! We are excited to welcome Sophie Heiding for a talk on "Computational Insights into Protein Adaptation Across Environmental Gradients" Date: June 10 Time: 4PM CET Register here:
tinyurl.com/prose-seminar2
Please share! 🧪
#MEvoSky
11 months ago
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Join us for the next ProSE Seminar! We are excited to welcome Sophie Heiding for a talk on "Computational Insights into Protein Adaptation Across Environmental Gradients" Date: June 10 Time: 4PM CET Register here:
tinyurl.com/prose-seminar2
Please share! 🧪
#MEvoSky
11 months ago
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Daniel Bolnick
12 months ago
Reminder that SSE members in Brazil, Colombia, Mexico, India, and 152 low-income countries around the world can still get FREE registration for the virtual Evolution meeting! Please share with your colleagues:
www.evolutionsociety.org/index.php?mo...
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Membership
Site description
https://www.evolutionsociety.org/index.php?module=content&type=user&func=view&pid=8#meeting
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Genome Biology and Evolution
12 months ago
Happy International Museum Day! Museums are essential repositories of specimens and information for biodiversity research. GBE has published much research in genomics and evolution that benefited from this crucial function of museums. See below ⬇️ and continue supporting museum research
#IMD2025
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Vikram Alva
12 months ago
Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone"
www.biorxiv.org/content/10.1...
@mpi-bio-fml.bsky.social
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