How does catalysis emerge from non-catalytic domains? In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead. A striking case of catalysis evolving from binding.

Night science is all about facilitating the import and export of ideas between scientists. Today at the workshop in Tel Aviv University we encouraged an open mind and an improvisational attitude to enthusiastically apply ‘night science’ thinking tools to our problems. 🙏 @judithberman11.bsky.social