If we doubled the allocation of MRFF grants, the fund would break even after 10 years BUT there would be twice as many economic returns from biomedical research innovations, boosting GDP and Australia's highly skilled workforce. As a reminder, the estimated long term ROI for MRFF grants is $4:$1

Given how stingy public research funding is overall, it's shocking that the #MRFF only spends 50% of what is allocated in the budget. This funds highly impactful, translational research focused fund that can DIRECTLY address the economic burdens of the healthcare system + improved patient outcomes

The National Association of Research Fellows join the call for full disbursement of the #MRFF #DiscoveriesNeedDollars www.theage.com.au/politics/fed...

Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology genomebiology.biomedcentral.com/articles/10....

Systematic benchmarking of computational methods to identify spatially variable genes. #SpatialTranscriptomics #MethodsBenchmarking #GenomeBiology genomebiology.biomedcentral.com/articles/10....

#EuroBioC2025 is over and it has been a blast! Thanks to all participants that came to @prbb.org for contributing to make such an enjoyable event and special thanks to the support from our sponsors, the organizing institutions @upf.edu @isglobal.org and the European @bioconductor.bsky.social Society

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

If this is right, it should prick the #AI bubble. I wouldn't want to be diagnosed by 'someone' who hallucinates, i.e. makes up stuff that looks like an answer, but isn't. [ht @goonerismspeek.bsky.social ]

Great work by our PhD student @fei-liyang.bsky.social in developing a @bioconductor.bsky.social package for the statistical analysis of barcode counts from clonal tracking/lineage tracing experiments. Preprint out now! 🎉 Catch her at the #EuroBioC2025 and #EMBOlineageTracing conferences.

Happening this Thursday! Don’t miss our workshop!

📢 Join us for the talk this Friday! Don't miss it!

This is the graph we show whenever someone talks about how back in the old days there weren't (people who are not whoever the person speaking thinks are the default). Mostly we do this to underscore that a rise in apparent frequency isn't always a rise in real frequency.

minimap2.com is potentially a phishing site. Please don't use anything from that website. github.com/lh3/minimap2...

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

New to @nextflow.io?✨Join us for Nextflow Training all of next week! Work through instructor-led videos and hands-on exercises at your own pace. Plus, the chance to earn an official completion certificate. 🎓 👉 Register now: hubs.la/Q03Jf_Zp0

Are you looking for a lectureship in biochemistry, molecular genetics, or bioinformatics? Come and enjoy the greatest place for kayak fishing and a fun research+teaching career. *there are other fun things to do here too.

Excellent editorial by my friend and colleague @pracheeac.bsky.social: "Academic Publishing Has Become a Racket" www.wsj.com/opinion/acad...

📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...

New blog post – A quick look at Roche's SBX lh3.github.io/2025/09/11/a...

I am beyond excited to announce that ggplot2 4.0.0 has just landed on CRAN. It's not every day we have a new major #ggplot2 release but it is a fitting 18 year birthday present for the package. Get an overview of the release in this blog post and be on the lookout for more in-depth posts #rstats

Now preprinted at arxiv.org/abs/2509.07357

I suspected this during my first postdoc, when I was working with snATAC-seq data. Nice to see people doing the hard work! Multiple overlapping binding sites determine #transcription factor occupancy doi.org/10.1038/s415...

Paraseq 0.4 is out now! With double the throughput for processing paired-end input :) github.com/noamteyssier...

This is an awesome example of the power of open source. @noamteyssier.bsky.social builds a versatile, efficient & easy to use crate for fastx & binseq parsing; @curiouscoding.nl notices how paired end (and any higher arity) processing can be sped up. Big PR, some discussion and BAM; big new release.

Just read the draft of Australia’s National Health & Medical Research Strategy. Great to see full funding of research being addressed as a need — but an emphasis on discovery research is missing. You can’t drive impact without fueling the pipeline with fundamental/discovery science.

Our annual @elixir-europe.org BioHackathon Europe Outpost is back! 🇦🇺 Join our fully-funded team in Melbourne this Nov to work on cool bioinformatics challenges & connect with global peers, no jet lag required. EOIs close THIS FRIDAY, Sep 5! #BioHackathon 🔗 www.biocommons.org.au/news/biohack...

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky url: academic.oup.com/icb/article-...

ICYMI Here are the links to all of our #BitesizeBioinformatics mini series webinars on #MachineLearning in #Biology 👇 🖥️ Machine Learning Examples in Biological Sciences 1: Linear Regression youtu.be/tIfpbDWnb0c?... More topics and useful info our website and YouTube channel too 1/5

#NextflowSummit registrations are now OPEN! 🎉 📅 October 23-24 | 🌍 Join from anywhere | 🎫 Free to attend The #NextflowSummit by @seqera.io brings together scientists from around the world to shape biotech R&D through community-driven innovation in bioinformatics hubs.la/Q03Fr0N90

It's taken more than 2 years but we can officially announce anndataR! There's still a lot of features to add but we hope a robust, "official", R-native H5AD reader/writer will unlock the defacto single-cell storage format for R users by avoiding issues with current solutions like zellkonverter.

🎉 scverse conference 2025 Registration & Call for Abstracts NOW OPEN! 🎉 We're excited to announce that registration and the call for abstracts are officially open for the scverse Conference 2025! Details in thread! 🧵 1/3

What are people using these days to manage their reading lists? I have many/various e-books spread across Kindle and Bookshop.org (+1000 recommend) and have no sensible electronic way of managing them when I'm looking for what to read next. Help?

A landmark research milestone, from a brilliant collaborative team, published in @natmed.nature.com 🔗 www.nature.com/articles/s41... @sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social

Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas. 🔗 www.wehi.edu.au/news/world-f...

📈 Omics data is growing at an unprecedented pace. The bottleneck is no longer generating data, it's analyzing it at scale. How can scientists ensure reproducible data analysis at scale, across diverse datasets, analysis tools, and rapidly evolving computational landscapes?

There's another scverse conference this year and it will be amazing! Register now: www.eventbrite.com/e/scverse-co...

🧬🖥️ Thrilled that our paper "Tree-based differential testing using inferential uncertainty for RNA-seq" genome.cshlp.org/content/earl..., led by @noorpratap.bsky.social, & in collab with @mikelove.bsky.social, @fennecpaaaw.bsky.social and Jason Fan is now accepted at @genomeresearch.bsky.social. 1/4

Every tech update now is like: "Great news, the word processor you've relied on for twenty years has learned to juggle! Is it good at it? No! Does it help in any way? Of course not! Has it made it insufferable to use? Oh, absolutely."

I'll be running a brand new workshop with @teunbrand.bsky.social for anyone who wants to make sure they are getting the most out of the constant development in ggplot2 and its ecosystem. Hope to see you there

🚨 Less than 48 hours left! 🚨 Abstract submissions for #ABACBS2025 close midnight Friday, Aug 15 — no extensions. www.abacbs.org/abacbs2025

Next in our #AI webinars: Stefano Mangiola @saigenci.bsky.social talks AI models in #SingleCell and if they can uncover biological patterns Anh TN Nguyen @monashuniversity.bsky.social shares how deep learning is accelerating #DrugDiscovery for GPCRs More info www.biocommons.org.au/events/ai-se...

This is an excellent long-read on AI and science with lots of useful further reading www.aisnakeoil.com/p/could-ai-s.... Well worth your time to actually read it.

🥱 Bored during #ScienceWeek2025? 🥼 Want to go on an adventure from the comfort of your pyjamas? 🧪🧬Why not go on an immersive & interactive virtual tour of a #Genomics #Lab? Wander around the @ramacgenomics.bsky.social Centre with impunity here ➡️ tinyurl.com/mr2cj4rj #UNSWscience

Researchers migrated to BlueSky. BlueSky metrics now included in Altmetrics 🧪 www.sciencedirect.com/science/arti...

taxburst v0.3.0 is now released - this is an update of the Krona visualization system for microbiome/metagenome taxonomy analyses. Enjoy!

I enjoyed reading this paper by @hubertr.bsky.social lab comparing artifacts in scRNAseq vs sc-Isoseq @pacbio.bsky.social Concluded standard pigeon filtering may remove too many isoforms, a problem we address in SQANTI3 through our Resue step. Any plans to try this? pubmed.ncbi.nlm.nih.gov/40630932/

Join us for the R-Ladies Networking Event at useR! 2025 Friday, August 8 at 6:30 PM | Gross Hall Room 103, Duke University. Come say hi, meet members, discover local chapters, and explore how to get involved. More details here: user2025.r-project.org/additional/r... #useR2025 #rladies

We’re growing @arcadiascience.com & are on the lookout for talent to run new pilot projects contributing to our broader goals. Seeking computational + wet lab fluency to iterate independently on new projects. If you’re a creative scientist w/ ambitious ideas, apply! jobs.lever.co/arcadiascien...