Our paper is out today! In @tiffmschmidt.bsky.social lab, we identified a single transcription factor, BRN3B, that shapes multiple, key features that define diverse ipRGC subtypes🧬👁️🐭

New preprints from the lab!! (2)

🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...

A big thanks to the NEI for supporting my new R01 and MCW for highlighting the research focus. We’ve already made some interesting discoveries and I’m excited to see how the research progresses for years to come. www.mcw.edu/mcwknowledge...

Happy to share the definitive version of our last paper about the role of TET enzymes and DNA demethylation in retinal development @clark-lab-retina.bsky.social journals.plos.org/plosbiology/...

Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…

TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl

If you're interested in how Mef2c tunes neuronal response to repulsive guidance cues in the cortex, here's a link to the paper: www.jneurosci.org/content/45/2...

So you want to study the optic nerve head. You’re thinking a Pax2-Cre driver should work, right? Well, think again: pubmed.ncbi.nlm.nih.gov/40300047/

Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1 www.biorxiv.org/content/10.1...

Funded PhD Studentship available in my lab at @lsiexeter.bsky.social. Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply! lsi.exeter.ac.uk/groups/hendr...

My lab studies mechanisms of pediatric glaucoma and the development of tissues affected (Schlemm's canal and trabecular meshwork). I am getting creative with fundraising because, well... So if you know someone who might be interested in funding our work: joinus.cuimc.columbia.edu/index.cfm?fu...

After injury some RGCs survive but do they thrive? In this collaboration with Jonathan Demb's lab (Yale), we looked into the physiology of resilient RGCs after axon injury. Their visual responses largely remain intact but they exhibit reduced intrinsic excitability, coincident with AIS disassembly.

Momentous day yesterday as Ivana Herrera successfully defended her doctoral thesis. Huge congratulations to her (seated center). Very proud of her!

We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...

Jack this morning: It warm!!

First post on this platform is to announce that our preprint is posted to bioRxiv: bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...

Happy Black History Month ✊🏾 This month, as we do every month, we celebrate Black history and all the many accomplishments our people have made inside and outside of science. We are all Black history yall. We love our community and wish you all joy and peace 🖤

Looking for a high qualtiy scientific meeting being held in Canada this year? The 12th Canadian Developmental Biology Meeting (Regional SDB @socdevbio.bsky.social meeting) is happening May 25-28 in Kelowna BC. Registration is now open! www.sdbonline.org/meeting?Reso...

NEW PAPER ALERT! In this paper that was posted today on @biorxivpreprint.bsky.social, Felix Simon from our lab at @ijmonod.bsky.social (with important contributions by Isabel Holguera and a small contribution from yours truly) completed the trifecta. www.biorxiv.org/content/10.1...

In one sentence (but see 🧵 for details): we show that CHD2 dosage critically regulates the autolysosomal pathway, which in turn impacts neurodevelopmental tempo. This matters for disease (epilepsy/autism), but also for evolution (neoteny/bradychrony) www.biorxiv.org/content/10.1...

Come join us @umontreal.ca - We're looking to recruit a Professor in the field of neurobiology, with a focus on linking neurodevelopment to neural circuit function and dysfunction. #neuroskyence #neuroscience 🧪 See ad below - www.fens.org/careers/job-...

Two new papers to... er... skeet? Blurt? Bluert? First is that our paper on the transcription factor Adnp and the ChAHP chromatin remodelling complex is now out. www.pnas.org/doi/10.1073/... I already blurted the paper here: bsky.app/profile/pier...

Excited to take on a new role as the next Director of the Regenerative Medicine Program at the Ottawa Hospital Research Institute ! Can't wait to support/promote innovative ideas, and engage collaborative networks to positively impact the life of patients and their care givers. Exciting times ahead!

Did Santa really just send me proofs for Xmas? Yes. Yes he did.

Kid 1: COVID. Kid 2: tonsilitis (not COVID somehow). Car battery: dead. How's your Saturday going so far? 😂

New preprint from the lab. This one is (again) about about modelling neurodevelopmental disorders. Here, we focus on the link between chromatin remodellers (ADNP and CHD4) and cortical development. #NDDs and #cortical development. www.biorxiv.org/content/10.1...

Glad to see snowmen finally being emotionally honest with themselves.

Compound eye selfie

Today’s vibe

Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territory https://www.biorxiv.org/content/10.1101/2023.11.17.567616v1

Our latest manuscript on glia-to-neuron reprogramming is out. With @NguyetLe_ and @thanhhoang_, we figure out how to convert virtually all retinal Muller glia to neurons, induce them to proliferate, and even make a few photoreceptors./1 www.biorxiv.org/content/10.1...

Hello Bluesky! Pleased to share two papers from the lab - each focused on a pretty different topic! Hopefully it shows our range so-to-speak! bsky.app/profile/pier... bsky.app/profile/pier...

Paper #2 is about genome reorganization during retinal degeneration. www.nature.com/articles/s41...

Paper #1 is about modelling neurodevelopmental disorders t.co/VZLrXoLYOJ

Announcing the 2024 Gordon Research Conference on Visual System Development. We’re very excited about the program - whether you’re new to the meeting or returning, we hope you’ll apply! Trainees - also check out the GRS pre-meeting.