Gilles Gouspillou
@gillesgouspillou.bsky.social
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Scientist interested in skeletal muscle physiology, mitochondrial biology and aging.
pinned post!
Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social
, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
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Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791%2825%2900041-2
8 months ago
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Gilles Gouspillou
Aging Science News
about 2 months ago
Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
onlinelibrary.wiley.com/doi/full/10....
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Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
Circulating taurine concentration is not associated with age, muscle mass, strength, physical performance, or mitochondrial function in humans. Taurine deficiency is therefore unlikely to be a primar....
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.70191?campaign=wolearlyview
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Gilles Gouspillou
Julien Ochala
5 months ago
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders
@lundbeckfonden.bsky.social
@novo-nordisk.bsky.social
@ucph.bsky.social
@myoblue.bsky.social
#diabetes
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Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
https://link.springer.com/article/10.1007/s00125-025-06436-0
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Gilles Gouspillou
The Journal of Physiology
6 months ago
📣 CALL FOR PAPERS 📣 Organised by
@pgreenhaff.bsky.social
& focusing on: 🚑 Injury and rehabilitation ⛰️ Altitude physiology 🦵 Muscle adaptation 🚴 Exercise training 💉 Pharmacological interventions ⚙️ Body composition 🔗
buff.ly/2sVbnLk
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www.science.org/doi/10.1126/...
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Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
https://www.science.org/doi/10.1126/sciadv.adr6415
6 months ago
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Gilles Gouspillou
Geoff Power
6 months ago
The PowerLab (
uofgpowerlab.weebly.com
) is having some big turnover this summer and this opens the door to take on new PhD students to work on projects related to muscular adaptations to use/disuse across various structural levels. Happy to chat!!
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My Site
About Me I am currently an Associate Professor in the Department of Human Health and Nutritional Sciences (HHNS) in the College of Biological Sciences (CBS) at the University of Guelph and Director...
https://uofgpowerlab.weebly.com
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www.nature.com/articles/s41...
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Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis - Nature Communications
The transcription factor Myc stimulates growth in many cells. This study shows that Myc expression is essential in muscle stem cells to support muscle growth, but is neither sufficient nor necessary f...
https://www.nature.com/articles/s41467-025-58542-7
6 months ago
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Gilles Gouspillou
Christian Frezza
6 months ago
www.nature.com/articles/s41...
A human brain map of mitochondrial respiratory capacity and diversity
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A human brain map of mitochondrial respiratory capacity and diversity - Nature
The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...
https://www.nature.com/articles/s41586-025-08740-6
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Gilles Gouspillou
Russ at UF
6 months ago
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore.
www.science.org/doi/10.1126/...
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In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
https://www.science.org/doi/10.1126/science.ads8738
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www.nature.com/articles/s42...
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SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 - Nature Metabolism
SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.
https://www.nature.com/articles/s42255-025-01235-8
6 months ago
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reposted by
Gilles Gouspillou
Vincent Marcangeli
7 months ago
« Use of sedentary subjects as the control group has led to potentially misleading interpretations. If physically active individuals were designated as the control group, a different interpretation would have been drawn ». 21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
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Sedentary death syndrome - PubMed
Sedentary death syndrome (SeDS) is a major public health burden due to its causing multiple chronic diseases and millions of premature deaths each year. Despite the impact of physical inactivity, very...
https://pubmed.ncbi.nlm.nih.gov/15317985/
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Gilles Gouspillou
Craig A. Goodman
7 months ago
Macrophages excite muscle spindles with glutamate to bolster locomotion
www.nature.com/articles/s41...
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Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
https://www.nature.com/articles/s41586-024-08272-5
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Gilles Gouspillou
Russ at UF
7 months ago
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions:
pubmed.ncbi.nlm.nih.gov/40059508/
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Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...
https://pubmed.ncbi.nlm.nih.gov/40059508/
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reposted by
Gilles Gouspillou
Craig A. Goodman
7 months ago
Immunomodulatory role of the stem cell circadian clock in muscle repair
www.science.org/doi/10.1126/...
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Immunomodulatory role of the stem cell circadian clock in muscle repair
The stem cell circadian clock orchestrates metabolic and immune signaling to time muscle regeneration following injury.
https://www.science.org/doi/10.1126/sciadv.adq8538
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Clonal dynamics and somatic evolution of haematopoiesis in mouse
www.nature.com/articles/s41...
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Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature
Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...
https://www.nature.com/articles/s41586-025-08625-8
7 months ago
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Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
www.nature.com/articles/s41...
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Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications
Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...
https://www.nature.com/articles/s41467-025-57487-1
7 months ago
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Structure of mitochondrial pyruvate carrier and its inhibition mechanism
www.nature.com/articles/s41...
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Structure of mitochondrial pyruvate carrier and its inhibition mechanism - Nature
Structural findings define the architecture of the mitochondrial pyruvate carrier, delineate its substrate-binding site and translocation pathway, and reveal its major conformational states, providing...
https://www.nature.com/articles/s41586-025-08667-y
7 months ago
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Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
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Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications
Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...
https://www.nature.com/articles/s41467-025-57405-5
7 months ago
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physoc.onlinelibrary.wiley.com/doi/full/10....
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Dietary nitrate supplementation mitigates age‐related changes at the neuromuscular junction in mice
Abstract figure legend Ageing is associated with a decline in muscle mass and strength, namely sarcopenia, significantly impacting the quality of life in older individuals. Different strategies are b...
https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP287592
7 months ago
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www.nature.com/articles/s41...
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Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature
We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...
https://www.nature.com/articles/s41586-025-08590-2
7 months ago
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Gilles Gouspillou
Kevin Murach
7 months ago
@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth
#myoblue
www.sciencedirect.com/science/arti...
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A primer on global molecular responses to exercise in skeletal muscle: Omics in focus
Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran…
https://www.sciencedirect.com/science/article/pii/S2095254625000079
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Gilles Gouspillou
The Journal of Physiology
8 months ago
🚨APPLICATIONS CLOSE FRIDAY 21st FEBRUARY🚨 For our 2025 Editorial Board Fellowship scheme! Read about Josiane Broussard's experience as an Editorial Fellow🎓👇 🔗
https://buff.ly/2s5K83y
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Gilles Gouspillou
Experimental Physiology
8 months ago
💪CALL FOR PAPERS💪 For our "New perspectives on the physiological basis of muscle loss"
#SpecialIssue
! This issue will highlight the latest research underpinning the integrative mechanisms driving muscle loss! Click the link and submit your research! 🔗https://buff.ly/3D97oFr
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Gilles Gouspillou
Vincent Marcangeli
8 months ago
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️
www.cell.com/cell-reports...
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Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791%2825%2900041-2
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www.nature.com/articles/s41...
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Mitofusin 2 displays fusion-independent roles in proteostasis surveillance - Nature Communications
Mitochondria influence cellular proteostasis, though the proteins that mediate this role are not well described. Here they show that the mitochondrial protein MFN2 interacts with the proteasome and wi...
https://www.nature.com/articles/s41467-025-56673-5
8 months ago
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reposted by
Gilles Gouspillou
Dada Pisconti
8 months ago
#MyoBlue
add a skeleton here at some point
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Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social
, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
loading . . .
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791%2825%2900041-2
8 months ago
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www.nature.com/articles/s43...
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Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging - Nature Aging
Using single-cell imaging of a fluorescent chaperone-mediated autophagy (CMA) reporter and RNA sequencing data, the authors present a resource on basal CMA activity across organs, cell types and sexes...
https://www.nature.com/articles/s43587-024-00799-6
8 months ago
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www.cell.com/cell/fulltex...
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Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...
https://www.cell.com/cell/fulltext/S0092-8674(24)01420-X
8 months ago
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reposted by
Gilles Gouspillou
Craig A. Goodman
8 months ago
The roles of mitochondria in global and local intracellular calcium signalling
www.nature.com/articles/s41...
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The roles of mitochondria in global and local intracellular calcium signalling - Nature Reviews Molecular Cell Biology
Mitochondria rapidly take up calcium (Ca2+) from the cytoplasm and neighbouring organelles upon an increase in local and global calcium levels, thereby stimulating metabolism and regulating processes ...
https://www.nature.com/articles/s41580-024-00820-1
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www.nature.com/articles/s41...
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Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues - Nature Methods
Spatial-Mux-seq offers a multimodal spatial platform capable of profiling multiple molecular modalities, including the transcriptome, chromatin accessibility, histone modifications and targeted protei...
https://www.nature.com/articles/s41592-024-02576-0
8 months ago
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