Pain across the lifespan: global and regional reference curves from 6.1 million individuals in 118 countries. Great work @mfilling.bsky.social #PainResearch www.medrxiv.org/content/10.6...

Nature research paper: Shared and language-specific phonological processing in the human temporal lobe go.nature.com/4r9HExe

Our lab is hiring! We're lookgin for an MSc trainee and a PhD trainee to investigate the neural underpinnings of pain. If you are interested in pain and brain imaging, please reach out! Informal enquiries are encouraged.

Nature research paper: Specificity, length and luck drive gene rankings in association studies go.nature.com/47Fsqax

New human DRG atlas just dropped! 🌟

Opioid deprescribing is advised when risks of opioid use outweigh benefits. A tailored, patient-centered plan with gradual dose reduction, monitoring, and support can improve outcomes and reduce harm. Learn more: nej.md/4oL3fu2 #MedSky @sydney.edu.au

This new prospective study followed 108 individuals with acute low back pain. Their immune profiles predicted transition from acute to chronic low back pain in a sex- and age-specific manner with some pretty impressive AUCs. journals.lww.com/pain/abstrac... #neuroskyence #painresearch #physio

🧠Pioneered study: Hypnosis Enhances the Effects of Pain Education in Patients With Chronic Back Pain: A Randomized Controlled Trial. Open access paper: pubmed.ncbi.nlm.nih.gov/29654980/ #mind-body #pain #chronicpain #hypnosis #PainResearch

Galosi et al. find that cold and warm detection thresholds by QST, combined with small-fiber-related clinical abnormalities, achieve high sensitivity and specificity in diagnosing small fiber neuropathy. Learn more in #PAIN bit.ly/42blyjc

Beisswanger et al. use microneurography to reveal C-nociceptor dysfunction beyond conventional testing, offering insights into the role of C-nociceptors in ongoing neuropathic pain. Learn more in #PAIN bit.ly/4nqvWMG

A new review focuses on the ways in which clinicians recognize and manage in-the-moment experiences of uncertainty in practice and provides practical strategies that teachers can use to help trainees build confidence in managing uncertainty. Read the full review: nej.md/43xKSQX #MedSky #MedEd

Precision Functional Mapping of Imagined and Experienced Pain https://www.biorxiv.org/content/10.1101/2025.08.06.668906v1

Beautiful paper on #biomarkers, #neuromarkers, and psychosocial predictors of chronic pain and associated #chronicdiseases. A tour de force. @mfilling.bsky.social @evp82.bsky.social www.nature.com/articles/s41...

🔥 Most important paper I've read all year🔥 👉 Injury/disease doesn't reliably predict pain 👉 Biomarkers alone can't explain pain 👉 PSYCHOSOCIAL factors reliably determine chronic pain 👉 Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors www.nature.com/articles/s41...

#NAPster publication

A drug to treat migraine, ubrogepant, is also found to reduce common non-headache symptoms that occur in the hours preceding a migraine headache, according to the results of a large phase three clinical trial published in Nature Medicine. go.nature.com/4dkxBPE #medsky 🧪

Thrilled to share our new paper in Nature Human Behaviour! nature.com/articles/s41... We show that combining biological 🧬 and psychosocial 📋 data offers a much stronger, more reliable path to predicting pain and diagnosis. 🧵

If you're trying to predict pain, worth a look !

Our new @NatureHumBehav paper shows why we need a holistic pain biomarker framework. ML on blood tests, brain/bone imaging & genetics predicts clinical diagnoses but falls short on subjective pain. Adding psychosocial (mood, sleep, stress) boosts both. shorturl.at/vxxeO

Different risk factors predict the occurrence vs. the severity of tinnitus. Hearing health drives whether you get it, but mood, neuroticism & sleep influence how bothersome it becomes.

How will you use A2CPS data to answer questions about pain, health and disease? Baseline data available now. More at a2cps.org/researchers/

A trial has drawn links between fibromyalgia and alterations of the gut microbiome https://go.nature.com/3GpJRSs

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease https://www.biorxiv.org/content/10.1101/2025.04.17.648358v1

Our partnership with @glaucomflecken.bsky.social continues as he summarizes new research into fracture prevention with infrequent zoledronate in women 50 to 60 years of age. Access the article for free: nej.md/DrG15 #MedSky

Not shocking, but important: nociceptors fire → glutamate is released — with or without neuropeptides like SP or CGRP. This paper pushes the field past the idea that pain = peripheral neuropeptide release. Time to stop oversimplifying pain circuits and behaviors to single-molecule targets

Nature research paper: Translational genomics of osteoarthritis in 1,962,069 individuals https://go.nature.com/4juvSsT

🧠🐭📊🔬🧬BIG PREPRINT UPDATES: Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with our synthetic opioid gene therapy www.biorxiv.org/content/10.1... 1/15

Excited to share our latest publication, out now in @ScienceAdvances: “Thermosensory predictive coding underpins an illusion of pain.” www.science.org/doi/10.1126/.... Read the full thread for details!

Spinal processing of spatiotemporally diverse tactile stimuli: Implications for allodynia and spinal cord stimulation https://www.biorxiv.org/content/10.1101/2025.03.10.642392v1

Simultaneous brain-spinal fMRI

A Review in Nature Reviews Genetics examines computational and statistical challenges that must be addressed for the rigorous construction of interpretable epigenetic clocks at cell-type and single-cell resolution. https://go.nature.com/3EKFgt0 🔒

My brilliant student Matt Cormie became interested in the thermal grill, and designed a study to see if the TG can elicit primary/secondary hyperalgesia and/or brush allodynia. These could help us parse out the mechanisms involved. www.biorxiv.org/content/10.1...

#PainResearch www.nature.com/articles/s41...

Nature research paper: A crucial role for the cortical amygdala in shaping social encounters https://go.nature.com/4gDzRkW

🚨Job alert 🚨 @pennmedicine.bsky.social Neuroscience Department is looking for a new Chair 🪑 jobs.chronicle.com/job/37789107/c… Do you love brains, bureaucracy, and balancing faculty egos? Want to run a top dept in Philly? Apply today—are you Gritty enough#GoBirdsds 🦅

New study with combined 7 Tesla MRI imaging and PET scan finds altered structures of nerves and neuroinflammation in migraine patients. Vey robust design that includes a control group and same cases as right/left side dominant migraines as controls. #painresearch #neuroskyence #physio 🧪🛟

our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology open access, open data and code w/ @drsmschabrun.bsky.social jamanetwork.com/journals/jam...

Exciting news! The wait is over - the first release of public data from #A2CPS is here, available via the NDA data portal. Learn more at our For Researchers pages, and see our preprint all about it at @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...