Beautiful paper on #biomarkers, #neuromarkers, and psychosocial predictors of chronic pain and associated #chronicdiseases. A tour de force. @mfilling.bsky.social @evp82.bsky.social www.nature.com/articles/s41...

🔥 Most important paper I've read all year🔥 👉 Injury/disease doesn't reliably predict pain 👉 Biomarkers alone can't explain pain 👉 PSYCHOSOCIAL factors reliably determine chronic pain 👉 Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors www.nature.com/articles/s41...

Thrilled to share our new paper in Nature Human Behaviour! nature.com/articles/s41... We show that combining biological 🧬 and psychosocial 📋 data offers a much stronger, more reliable path to predicting pain and diagnosis. 🧵

Our new @NatureHumBehav paper shows why we need a holistic pain biomarker framework. ML on blood tests, brain/bone imaging & genetics predicts clinical diagnoses but falls short on subjective pain. Adding psychosocial (mood, sleep, stress) boosts both. shorturl.at/vxxeO