Pourya Naderi
@pouryany.bsky.social
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Comp bio | Networks | Noncoding RNAs | Neurodegeneration. Scientist @HarvardMed. UNCcharlotte Alum.
reposted by
Pourya Naderi
Kuchroo Lab
8 months ago
Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the
@harvard.edu
Gazette 👇 🧪
news.harvard.edu/gazette/stor...
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Immune-system strategy used to treat cancer may help with Alzheimer’s — Harvard Gazette
Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice.
https://news.harvard.edu/gazette/story/2025/04/immune-system-strategy-used-to-treat-cancer-may-help-with-alzheimers/
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reposted by
Pourya Naderi
Scripps Research
9 months ago
The Lipp Lab (
@lippilab.bsky.social
) has uncovered how microRNAs guide the development of Purkinje cells—rare neurons tied to movement and autism. Published in Neuron, a
@cellpress.bsky.social
journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.
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How microRNAs act as a “blueprint” for the developing brain
https://www.scripps.edu/news-and-events/press-room/2025/20250402-lippi-neuron.html
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If you’re attending
#adpd2025
drop by to hear about our latest research on
#Alzheimers
drug target discovery Title: Bringing precision modeling to Alzheimer's Disease. Fri, 04.04.2025 | 18:40 - 19:40 | Hall C
add a skeleton here at some point
9 months ago
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reposted by
Pourya Naderi
Winston Hide
9 months ago
#adpd2025
insights into the Alzheimer’s continuum. 4/4/25 @19:25
@pouryany.bsky.social
will present our new approach to discovering validated targets for AD therapy
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reposted by
Pourya Naderi
Arjun Raj
9 months ago
Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.
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reposted by
Pourya Naderi
Rodrigo Suárez, PhD
11 months ago
p38 MAPK-MK2 inhibitors (e.g. losmapimod) show new promises in treating Alzheimer's disease. Today
@cp-neuron.bsky.social
www.cell.com/neuron/fullt...
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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
Naderi and Kwak et al. developed IPAA, an integrated cellular/bioinformatics platform. IPAA derisks drug discovery by integrating Alzheimer’s brain gene expression with cellular model functional reado...
https://www.cell.com/neuron/fulltext/S0896-6273(24)00800-6
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reposted by
Pourya Naderi
Jonathan Pritchard
11 months ago
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A đź§µ
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reposted by
Pourya Naderi
Winston Hide
11 months ago
What are the molecular and cellular hallmarks of resilience and resistance to Alzheimer's Disease? Awesome discoveries with
@pouryany.bsky.social
@isabelscst.bsky.social
We’re growing our team—deliver translation with omics!
#cureAlzheimersFund
#Postdoc
shorturl.at/bGyUqhife
hidelab.net
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New preprint alert! Check out our manuscript on molecular and cellular hallmarks of resilience and resistance to Alzheimer's Disease (AD) led by
@isabelscst.bsky.social
and myself from
@winhide.bsky.social
's Lab. Paper link:
doi.org/10.1101/2025...
#Alzheimers
#Genomics
#Aging
Details 👇 1/n
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Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer’s disease
Background A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer’s disease (AD) pathology, known as cognitive resilience. Understanding the mol...
https://doi.org/10.1101/2025.01.13.632801
11 months ago
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reposted by
Pourya Naderi
BrunetLab
12 months ago
Thrilled to see this paper out!! đź§Ş Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with
@jameszou.bsky.social
!
rdcu.be/d33uQ
đź§µ
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Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
https://rdcu.be/d33uQ
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reposted by
Pourya Naderi
Eric Topol
about 1 year ago
Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy
www.nature.com/articles/s43...
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IL-23R is a senescence-linked circulating and tissue biomarker of aging - Nature Aging
Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...
https://www.nature.com/articles/s43587-024-00752-7
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Check out our recent work in Neuron! Our platform helps derisk preclinical to clinical translation by precisely pinning down models that recapitulate pathogenic functions in Alzheimer’s disease brains. Feel free to dm if you are interested in knowing more.
add a skeleton here at some point
about 1 year ago
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reposted by
Pourya Naderi
Babak Alipanahi
about 1 year ago
Today was a great day! Our paper on using an AI platform for cell-free RNA liquid biopsy is finally published in Nature Communications! Huge thanks to our amazing team at
@exai.bio
for making this happen! The code is open-source and readily available.
www.nature.com/articles/s41...
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Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer - Nature Communications
A generative AI model, Orion, learns a robust and generalizable pattern of non-small cell lung cancer from cancer-specific circulating non-coding RNAs. Orion enhances the performance of liquid biopsy ...
https://www.nature.com/articles/s41467-024-53851-9
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reposted by
Pourya Naderi
🇲🇽 Leonardo Collado-Torres
about 1 year ago
On the topic of non-negative matrix factorization (NMF, implemented in
#RcppML
among other
#RStats
📦 s) the
#NSF
paper by Townes & Engelhart citation #7 was great! đź’Ż (
@lahuuki.bsky.social
journal club 📹🔜!)
www.nature.com/articles/445...
published in 1999 shows how NMF gets face elements unlike PCA
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Just gonna put up some hashtag to find peeps.
#genomics
#bioinformatics
#singlecell
#Alzheimer’s
#systemsbiology
#compbio
#omics
about 1 year ago
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