Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the @harvard.edu Gazette 👇 🧪 news.harvard.edu/gazette/stor...

The Lipp Lab (@lippilab.bsky.social) has uncovered how microRNAs guide the development of Purkinje cells—rare neurons tied to movement and autism. Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.

If you’re attending #adpd2025 drop by to hear about our latest research on #Alzheimers drug target discovery Title: Bringing precision modeling to Alzheimer's Disease. Fri, 04.04.2025 | 18:40 - 19:40 | Hall C

#adpd2025 insights into the Alzheimer’s continuum. 4/4/25 @19:25 @pouryany.bsky.social will present our new approach to discovering validated targets for AD therapy

Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.

p38 MAPK-MK2 inhibitors (e.g. losmapimod) show new promises in treating Alzheimer's disease. Today @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

What are the molecular and cellular hallmarks of resilience and resistance to Alzheimer's Disease? Awesome discoveries with @pouryany.bsky.social @isabelscst.bsky.social We’re growing our team—deliver translation with omics! #cureAlzheimersFund #Postdoc shorturl.at/bGyUqhife hidelab.net

New preprint alert! Check out our manuscript on molecular and cellular hallmarks of resilience and resistance to Alzheimer's Disease (AD) led by @isabelscst.bsky.social and myself from @winhide.bsky.social's Lab. Paper link: doi.org/10.1101/2025... #Alzheimers #Genomics #Aging Details 👇 1/n

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy www.nature.com/articles/s43...

Check out our recent work in Neuron! Our platform helps derisk preclinical to clinical translation by precisely pinning down models that recapitulate pathogenic functions in Alzheimer’s disease brains. Feel free to dm if you are interested in knowing more.

Today was a great day! Our paper on using an AI platform for cell-free RNA liquid biopsy is finally published in Nature Communications! Huge thanks to our amazing team at @exai.bio for making this happen! The code is open-source and readily available. www.nature.com/articles/s41...

On the topic of non-negative matrix factorization (NMF, implemented in #RcppML among other #RStats 📦 s) the #NSF paper by Townes & Engelhart citation #7 was great! 💯 (@lahuuki.bsky.social journal club 📹🔜!) www.nature.com/articles/445... published in 1999 shows how NMF gets face elements unlike PCA

Just gonna put up some hashtag to find peeps. #genomics #bioinformatics #singlecell #Alzheimer’s #systemsbiology #compbio #omics