There is a lot of hype around #multiomic profiling going around, particularly in the promise of precision medicine. Here I talk about how adding #proteomic measurements can move the needle on understanding patient prognosis in #AML. www.sciencedirect.com/science/arti...

After a very frustrating weekend of editing a manuscript by a junior scientist who really. liked. words. I ordered and gifted a new copy of Strunk and White. Probably the single most satisfying thing I've done all month! #elementsofstyle #scientificwriting #allwritingreally #mentorship

I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA 10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)

An important message from my wife, a leading breast imaging researcher, and a 10+ year survivor of invasive breast cancer found because she knew enough to advocate for her own effective breast cancer screening.

So I missed the boat on making a #30under30 or #40under40 list, but today I just learned that there's a #50over50 list so I have all sorts of new career goals: www.forbes.com/50over50/

Any day I can say “one thing can’t be more significant than another” when referring to p-values is a good day. #knowyourstats

Carrying on our well established tradition of interdisciplinary team science at the #AI Jam Hackathon here at #PNNLSeattle . I’m excited to see what these teams come up with @energygov.bsky.social

I want to see the west coast version of this article: www.nytimes.com/2025/09/04/o... This type of conversational tactic, can often be confused as 'interrupting' and 'making the conversation about me' here...

Great opportunity from the @alzassociation.bsky.social and the Michael J Fox Foundation for early stage investigators whose NIH funding has been disrupted: www.alz.org/research/for... Bravo!

An oldie but goody: "Go to statement considered harmful" by Edward Dijkstra homepages.cwi.nl/~storm/teach...

Just landed in Cambridge, MA for the @asbmb.bsky.social meeting on #proteomics and found my coworkers at #PNNL. Come find us to talk about how we’re using proteomics in biological research!

So well said: every scientific finding is built upon the science of others - you start breaking the American scientific engine and everyone will suffer: scientists, industry, doctors, voters, etc. It is all linked together.

More than 90 scientists at the National Institutes of Health signed a letter in protest of Trump administration policies they say are harming people’s health, in a rare sign of open resistance by career government employees.

I think it's important to continuously reiterate that federal science funding grants in the US (and elsewhere) are made because the government, with the input of panels of independent experts, have concluded that the work being done is IN THE INTEREST OF THE NATION.

I realize that as a retired professor I have a responsibility to say more on this than I have. International students are essential to the fiscal bottom line of almost every university. This is an unambiguous attempt to destroy Harvard—permanently. And he won’t stop with Harvard. This is madness.

Live footage of me returning to my inbox after a challenging grant submission, NIH site visit, and weekend of parenting teenagers.

I was today years old when I learned that the Magic Schoolbus was an NSF-funded project.

Elevating this so that it gets more eyes. This type of grant termination, with no scientific cause or warning, will not only decimate our scientific infrastructure but will have horrific consequences downstream for drug development and subsequently human health.

Space!!

Yesterday all of this was happening. It's a hellhole for sure, definitely don't come here.

always

Came in to find this on my desk today. Pretty great way to return to work. @effinbirds.com #awesomecolleagues

NEW @npr.org: ~100 days in, what has DOGE actually done? It hasn't delivered on its promised savings, efficiency or transparency in meaningful ways. But Elon Musk's DOGE *has* amassed unprecedented power over data. A deep dive with @shannonbond.bsky.social:

Who is at #AACR25? I’m here representing my group’s work at the intersection of AI and drug resistance in cancer, and want to hear about what you’re doing!(1/4)

A programmer had a problem. He thought — "I know, I'll use async!" has problems Now . two he

Follow this one closely. If Mr. Mahdawi is not granted due process, none of us can count on it.

Stop telling American scientists to just move to another country challenge

Not to be super gatekeeper-y, but can we discuss the elevation of a white, male individual without relevant scientific training because resegregationists like his message? Such a clear example of whiteness and maleness being credentials in science, in and of themselves undark.org/2025/03/26/u...

qrt with your favorite and/or most creative scientific poster Here's one that I just made to connect comptuational tools I'm developing or helping to develop for a recent workshop. Hand drawn (except the obvious parts that aren't)

Noticeably silent amid the upheaval at HHS? Big pharma. Every new drug has NIH somewhere in its DNA--and NIH funding supports the training of their workforce. Now they're finding out FDA isn't safe, either. Wrote about how keeping quiet isn't working My latest @opinion.bloomberg.com (gift link):

Carnage. www.nature.com/articles/d41...

Every network should be covering this. www.youtube.com/watch?v=rCUK...

Read about some cool stuff @sargoshoe.bsky.social and I are doing! Biology’s “dark matter” is proteins & molecules whose roles are not understood. At PNNL, we use network biology to map hidden interactions, illuminating it for medicine, bioengineering, and bioeconomy www.pnnl.gov/news-media/u...

Come read about some of the work @biodataganache.bsky.social and I do at #PNNL using biological networks to improve our understanding of proteins, cells, and microbes. www.pnnl.gov/news-media/u...

Tumor biologists! do we know that tumors produce mRNA (or RNA generally) more quickly than healthy tissues? maybe there are old papers on this? (pls reski)

Me in the national security team group chat

PSA: if you see a p-value of "<2.2e-16" please don't report it - it's a feature of the precision of R www.quora.com/Why-do-most-...

This program has fueled life-changing treatments for patients with #NF1, which has now been discontinued. Clinical trials are at risk, and patients will suffer. More than 50% of CDMRP areas were terminated and money re-allocated.

We are very close to a near cure for two of the highest-mortality cancers we know: glioblastoma and pancreatic cancer. These are both mRNA based treatments which are losing their funding during stage I and II trials. Thousands will die needlessly because of this motherfucker and his lies.

We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!

This poem. Every single word.

This is heartbreaking. #CC01.

Of course the Trump campaign against Columbia is not about DEI or anti-semitism - it's about some pettiness over a business deal gone bad: www.nytimes.com/2025/03/21/n...

Live footage of my colleagues when I showed up at lunch today instead of eating at my desk. Aside from the snarky 'see you in three months' from one guy as I left, it was nice to be so appreciated :)

Every time I see another story like this, I think of final lines of the Hollow Men poem: "This is the way the world ends Not with a bang but a wimper." allpoetry.com/the-hollow-men

Talk about a gut punch. After hearing that the DoD CDMRP is cancelling the Neurofibromatosis Research Program, I go to the website for confirmation only to find an NF1 finding at the very top of the 'latest news'. This will be a hit to NF1 and rare cancer research for decades to come.

Kind of great to see coverage of the use of AI in drug repurposing. I think it's a really great use of existing scientific research and datasets, and holds so much promise! www.nytimes.com/2025/03/20/w...

Happy Barkley Marathons Day to all who celebrate! I love that Keith is on here now, too. Follow along with him for one of the quirkiest—and most brutal—sporting events on Earth. #BM100