My ISCB 2025 talk on DecoDen in the HITSeq COSI is now on YouTube! Check it out - youtu.be/-0EOIDzWniU 🧪🧬🖥️

Thank you to @narjournal.bsky.social for sharing our work! We used NMF and half-sibling regression to build DecoDen: a tool that de-biases chromatin measurements to reveal clearer signals in personal epigenomes. Really happy to see this out as an Editor's Choice! Code: github.com/ntanmayee/de...

This was never really the case. We have known since the 1960s that some of our non-coding DNA has a crucial role in gene regulation: turning the expression of coding genes on & off. It’s been clear for decades that the regulatory DNA is at least comparable in proportion to the protein-coding DNA. /5

Great thread!

Now out in NAR Genomics and Bioinformatics! academic.oup.com/nargab/artic...

I was at the Symposium on Causality in Biology & AI in Barcelona. I presented a flash talk on inferring time-varying gene regulatory networks from time series scRNA-Seq data. Some results here - arxiv.org/abs/2110.06257

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

🤝 It was a real joy to reconnect with my PhD supervisor and mentor @gjbarton.bsky.social, as well as former colleagues @stuartmac44.bsky.social, @foreveremain.bsky.social, @mitsenkov.bsky.social, Vanessza Fentor, Douglas Freeburn, @tanmayee.bsky.social and @rosiegallagher.bsky.social!

Update: Our paper on "Causal Discovery from Conditionally Stationary Time Series" was presented two weeks ago at ICML 2025! arxiv.org/abs/2110.06257

One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/

We released our preprint on the CREsted package. CREsted allows for complete modeling of cell type-specific enhancer codes from scATAC-seq data. We demonstrate CREsted’s robust functionality in various species and tissues, and in vivo validate our findings: www.biorxiv.org/content/10.1...

Lungfish xkcd.com/3064

🚨New pre-print on Biorxiv! 🚨 Histone modifications are measured with ChIP-Seq, but the chromatin landscape introduces biases. We introduce DecoDen to simultaneously learn shared chromatin landscapes while de-biasing individual measurement tracks. Check it out: github.com/ntanmayee/de... 🧬 🖥️

Towards Personalized Epigenomics: Learning Shared Chromatin Landscapes and Joint De-Noising of Histone Modification Assays [new] Learns shared chromatin structure, correcting histone modification biases across epigenomes.

Towards Personalized Epigenomics: Learning Shared Chromatin Landscapes and Joint De-Noising of Histone Modification Assays https://www.biorxiv.org/content/10.1101/2025.03.04.641154v1

Towards Personalized Epigenomics: Learning Shared Chromatin Landscapes and Joint De-Noising of Histone Modification Assays https://www.biorxiv.org/content/10.1101/2025.03.04.641154v1

It's time for individuals and organizations in Europe and other democratic countries to move mission- or life-critical IT services and infrastructure outside the reach of the US government; noting that US tech companies have already largely subordinated themselves. www.huber.embl.de/group/posts/...

Let's talk about this Nature piece in more detail. I've rarely read something so anti-scientific anywhere short of the National Review. www.nature.com/articles/d41...

Please spread the word🙏: [PhD Position in Computational Evolutionary Transcriptomics] If you are interested in doing a PhD in gorgeous Scotland on 'Why embryo development goes wrong sometimes?', please consider applying and join our wonderful team in Dundee! www.dundee.ac.uk/phds/opportu...

RNA xkcd.com/3056

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz

(1/4) Thrilled to announce another major release of the HOCOMOCO motif collection, well-known for its silly name and rigorous approach to constructing and benchmarking DNA sequence motifs recognized by human and mouse transcription factors. hocomoco.autosome.org

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

An LLM "creates textual claims, and then predicts the citations that might be associated with similar text. Obviously, this practice violates all norms of scholarly citation. At best, LLMs gesticulate toward the shoulders of giants." Bender, West, and I contributed to this pro/con piece in PNAS.

Anagha Pavithran interviewed me and Janani about mentorship programs for Indian women interested STEM research. The article is finally out - rukhmabai.com/stem-collect... Thank you for your kind words about WISR! Glad to see other organisations like WoAA also mentioned :)

Great work from our colleagues in the Division of Computational Biology! Gabriele Schweikert's group work on machine learning techniques in epigenomics. scholar.google.com/citations?hl...

My PhD supervisor Gabriele Schweikert will be presenting two of my projects here! Please check it out 🧬🖥️ #DevBio #GeneReg

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

We need Epigenetic Hulk here.

Something that's been bugging me for a while in bioinformatics data analysis is this overreliance on packages, workflows and what's been called "cargo cult science". Can we have more conceptual thinking, more theory? Asking for what we really want to achieve and what we need to do gets us there.

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6

Incredible resource for DNA binding protein specificity from the Codebook consortium. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... Am reading these in detail & will have a lot to say. Stay tuned for thoughts.

Independent GroupLeader / PI position in AI in Genome Biology, Multimodal Omics at European Molecular Biology Lab (EMBL), Heidelberg! www.embl.org/jobs/positio... Looking in particular for researchers with quantitative/ methodological background who want to dive into leading edge biology research.

This illustration is so cute! I am going to use it to explain my PhD topic to my parents hehe

Hello! So excited to (finally) be here! I am a PhD candidate in computational biology. I work on understanding gene regulation using computational methods, specifically the interplay of chromatin dynamics and transcription. 🧬 🖥️ #HiSciSky #PhDSky #devbio