Glenn Carrington (@drgcarrington.bsky.social)

🚨 New review out in @jmrcm-springer.bsky.social 🧬 From the @michellepeckham.bsky.social lab, we summarise how smooth muscle myosin is regulated—covering autoinhibition, filament assembly, and structural insights into motor control and disease. 👉 rdcu.be/feUiX

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Smooth muscle contractile cytoskeleton in health and disease - Journal of Muscle Research and Cell Motility Smooth muscle cells are widespread in the human body, found in a range of tissues from the vasculature to the gut, airways, bladder and so on. They can be found as isolated cells or organised into syncytia (groups of cells). The organisation of the contractile cytoskeleton (smooth muscle actin and myosin filaments) is less well understood than that of striated (cardiac and skeletal) muscle. This review aims to explore what is known, the potential effects of mutations in smooth muscle actin, myosin and tropomyosin and how they lead to disease, and to highlight what we have still to learn about the smooth muscle contractile cytoskeleton. https://doi.org/10.1007/s10974-026-09731-4