🚨 New paper alert 🧬 Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances. We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state. 👉 tinyurl.com/4de8teyh

Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...

There was so much to unpack with this data, we teamed up with the marvellous @margotriggi.bsky.social to help explain what we think is going on. (Please also check out our model of central apparatus assembly here: www.biorxiv.org/content/10.6...)

The peer reviewed and updated version of this work is now online (although not quite the fully formatted version). We had an existential crisis about kinesin-1 regulation while developing this work, but we are super proud of everything we put into this project. www.cell.com/iscience/ful...

Cryo-EM structure of shutdown human non-muscle myosin 2A www.biorxiv.org/content/10.1101/2025.10.15.682586v1 #cryoem

Structure of the autoinhibited state of non-muscle myosin IIA - shows a different mechanism than seen for beta-cardiac myosin. www.biorxiv.org/content/10.1...

🚨 New paper alert! 🧬 Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉 We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪 👉 tinyurl.com/4fkxfv4e #cryoEM #myosin

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below: www.nature.com/articles/s41... Here's a cool animated summary

Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️ ➡️ www.nature.com/articles/s41... Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.

We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...

PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...