🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

Multimodal imaging of human fetal brain development at the mesoscopic scale using 11.7 T ex vivo MRI https://www.biorxiv.org/content/10.1101/2025.09.08.669657v1

🔥ATTENTION!🔥 Registration for the 2026 Noosa Brain Workshop is now open! Join us for some amazing science, sun, and surf in one of Australia's most beautiful beach towns. Details: tinyurl.com/arbc5pp6 Check out or incredible list of confirmed speakers. More to come...

Expanding canonical cortical cell type markers in the era of single-cell transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.26.672469v1

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary

JOB ALERT! We're seeking a postdoctoral scientist to join Developmental Imaging at @mcri.bsky.social in Melbourne. Role will involve working with international partners on a new project charting brain growth in children with NF-1 Please reach out for more information www.seek.com.au/job/86090834

JOB ALERT! We're seeking a postdoctoral scientist to join Developmental Imaging at @mcri.bsky.social in Melbourne. Role will involve working with international partners on a new project charting brain growth in children with NF-1 Please reach out for more information www.seek.com.au/job/86090834

Big fan of acronyms

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Human thalamocortical connectivity matures along the cortex’s sensorimotor–association axis www.nature.com/articles/s41...

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution www.nature.com/articles/s41...

Thrilled to present MIND! A model for how the sensorimotor–association axis of the neocortex develops. Huge thanks to the incredible multidisciplinary team who made this happen. www.biorxiv.org/content/10.1...

Addressing artifactual bias in large, automated MRI analyses of brain development | Nature Neuroscience www.nature.com/articles/s41...

On Friday/Saturday I have a poster (1205) on our work using generative network models, where I explore how heterochronous spatial gradients constrain brain connectivty 🧠⌛🏳️‍🌈 Also Saturday (11:30am; Great Hall) I have a talk on this work, so make sure you have recovered from club night in time for it!

For those at OHBM, check out my posters and talk! Today and tomorrow I (and maybe @garedaba.bsky.social) will be presenting my poster (1012) on our work linking fetal gene expression to neonatal connectome organisation 🧬🧠👶🌐 1/2 #OHBM #OHBM2025 (preprint here www.biorxiv.org/content/10.1... )

Accurate spatial localization of Allen Human Brain Atlas gene expression data for human neuroimaging https://www.biorxiv.org/content/10.1101/2025.06.02.656812v1

Macroscale Connectivity in the Octopus brain https://www.biorxiv.org/content/10.1101/2025.05.28.656524v1

Do you like brain network hubs?🧠🌐✳️Do you like genes?🧬What about neurodevelopment?👶What if I told you the latest work by @garedaba.bsky.social and myself combined all of these?🤯🤯🤯 See Gareth's thread for a primer of our findings, then read the paper for the details! www.biorxiv.org/content/10.1...

New preprint with @stuartoldham.bsky.social

DL-SAMER: A new deep learning + retrospective motion correction method for fast, motion-robust 3D brain #MRI — effective even in challenging pediatric cases. Check it out 👉 marketing.webassets.siemens-healthineers.com/7a1c195a6a39... #NeuroSky #RadSky #MagnetomWorld @harvardmed.bsky.social

Differential patterns of cortical expansion in fetal and preterm brain development https://www.biorxiv.org/content/10.1101/2025.05.19.653958v1

New preprint alert 📣📣📣 New results showing how strong the link between brain dynamics and structure is 💫👀🧪 "Spontaneous spiking statistics form unique area-specific fingerprints and reflect the hierarchy of cerebral cortex" 🐾🧠 www.biorxiv.org/content/10.1...

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/cor... Paper link below 👇

22q11 deletion selectively alters progenitor states and projection neuron identities in the developing cerebral cortex https://www.biorxiv.org/content/10.1101/2025.05.12.653556v1

New paper in Imaging Neuroscience by Weide Liu, Davood Karimi, et al: Streamline tractography of the fetal brain in utero with machine learning doi.org/10.1162/imag...

We are hiring! @aurinaarn.bsky.social and I are jointly looking for a talented Postdoc in Systems and Comp Neuro at Monash (AUS). If you like neuroimaging 🧠, comp models 💻, genetics 🧬, brain disorders 🤕, and/or evolution 🐵🐭, this could be the job for you!! careers.pageuppeople.com/513/cw/en/jo...

Happy to share that our article “Human lifespan changes in the brain’s functional connectome” is now published online at Nature Neuroscience @natureneuro.bsky.social ! Many thanks to all collaborators & data contributors, and the editor team & reviewers! www.nature.com/articles/s41...

New paper in Imaging Neuroscience by Vyacheslav R. Karolis, Joseph V. Hajnal, et al: The developing Human Connectome Project fetal functional MRI release: Methods and data structures doi.org/10.1162/imag...

I'm very excited to share my PhD work "Motifs of brain cortical folding from birth to adulthood: structural asymmetry and folding-functional links". We identified and characterised the lobe-wise folding patterns using both 1110 young adults (HCP) and 781 term-age neonates (dHCP & BIBS studies). 1/9

Ex vivo human brain volumetry: validation of magnetic resonance imaging measurements https://www.biorxiv.org/content/10.1101/2025.02.27.640654v1

Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health https://www.biorxiv.org/content/10.1101/2025.02.24.639850v1

Scanning Faster: Application in #Pediatric Neuroimaging by Michael Kean, Chief #MRI Technologist at The Royal Children’s Hospital/@mcri.bsky.social, Melbourne, Australia. Read the full article: marketing.webassets.siemens-healthineers.com/5cfbee50efc2... #MagnetomWorld #NeuroSky #ChildhoodCancerDay

So much research focusses on using brain connectivity to predict an individual's cognition, IQ, disease status, etc. BUT what about the inverse problem? Can personal data be used to build an individual's whole connectome? YES - with AI: www.biorxiv.org/content/10.1...

Towards automated fetal brain biometry reporting for 3-dimensional T2-weighted 0.55-3T magnetic resonance imaging at 20-40 weeks gestational age range https://www.medrxiv.org/content/10.1101/2025.02.06.25321808v1

Cortical maturation unfolds hierarchically, endowing the PFC with extended plasticity. But do timeframes of plasticity vary across PFC layers? With 7T quantitative myelin imaging, EEG, and cognitive data, we uncover heterochronous laminar maturation in the PFC 1/n. www.biorxiv.org/content/10.1...

Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories https://www.biorxiv.org/content/10.1101/2025.02.07.637106v1

New paper in Imaging Neuroscience by Stuart Oldham, Sina Mansour L., and Gareth Ball: Perinatal development of structural thalamocortical connectivity direct.mit.edu/imag/article...

Delighted to see this work, led by Matt Danyluik, out in @imagingneurosci.bsky.social Excellent technical piece on the caveats of methods for performing inference using PLS. A great piece of work for those using the technique and those who are interested in its robustness and reliability

Very nice Gene Dosage study by @kkumar.bsky.social and colleagues, looking at mirror effects of genomic deletions and duplications on cognition across the human cerebral cortex 🧪🧠🧬 www.biorxiv.org/content/10.1...

Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/ www.encodeproject.org/single-cell/...

Nice work!

😲

Wow!

Need cortical surface extraction which is time efficient while being more anatomically correct than classic pipelines? Try Qiang Ma's pipeline - tuned for neonatal (dHCP) but we are already using it for fetal and works on ya HCP arxiv.org/abs/2405.08783 github.com/m-qiang/dhcp...

😐

Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS

NeoCLIP: A Self-Supervised Foundation Model for the Interpretation of Neonatal Radiographs https://www.medrxiv.org/content/10.1101/2024.12.03.24318410v1

New paper from us about the gut-brain-axis in preterm infants. ➡️Bacterial community composition associates with MRI features of encephalopathy of prematurity esp Escherichia coli and Klebsiella spp. www.cell.com/cell-reports... 1/2