cool tuning of protein language models to individual families with ProteinTTT #Alphafoldology

Tessera iacta est. #volby2025

What would you use to setup and run a small MD simulations? no HPC, just for teaching and few small systems for thinking on structures? maybe to test some small reactions… #CompChemSky

K dnešnímu vystoupení ve Studiu 6 na @ceskatelevize.cz jsem si přichystal #3Dprint pomůcku - model bakteriofága phiX174, jenž posloužil @arcinstitute.org k přípravě nových bakteriofágů proti rezistentním kmenům E. coli

today #3Dprint protein is ferritin (PDB: 6I36) available here: www.printables.com/model/141627...

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+1 This paper is based on our experience on how Czech research teams offered their bioinformatics expertise to public health needs and coordinate within COG-CZ inofficial consortia. We started without funding and in biweekly reports monitored the COVID pandemics. pubmed.ncbi.nlm.nih.gov/40467653/

On personal #Alphafoldology notice - I’ve got my Professorship in Biomolecular Chemistry and Structural Biology today.

Binding affinities with #Alphafoldology using Boltz-2 ligands and ensembles included

#ELIXIRAHM 2025 in Thessaloniki started with bold vision

GOLD-plated #Alphafoldology? not so quickly…

I got weird #3Dmissprint on @prusa3d.com MK3.9 when printing 3D periodic tables from PLA (no supports needed) I got one printer head stuck with filament all over and on the second I was able to stop the print when this weird behavior occured:

Scoring #Alphafoldology with AF3score

skoda, ze cesky ty zakladni cislovky tak pekne nezni…

Nice short primer to basic #Alphafoldology tools

Moldina is freely available at github.com/It4innovatio...

Largest #Alphafoldology study so far…

@olinium42.bsky.social o popularizaci chemie právě teď na www.youtube.com/live/bjqJ1_y...

V Kutné hoře dnes ráno nebyla ani noha…

KULL #Alphafoldology to generate conformations to see side-chain dynamics with #AF2

so… which of preprint about AF3 at CASP16 should I read? @arneelof.bsky.social this one on @biorxivpreprint.bsky.social or the other on @authorea.com ?

Massive #Alphafoldology with MassiveFold

weekend #Alphafoldology ;)

A new preprint from our lab at @fchupol.bsky.social

Povedená chemická opera… youtu.be/jVN1utwXw0U?...

last two student sections of 1st @elixircz.bsky.social PhD conference starts with Aleksandra Ivanova from Pavel Polishchuk group at IMTM UPOL with StreaMD

“Bluesky has won”. Please retweet… 😉

we continue 1st @elixircz.bsky.social PhD conference with keynote by Martin Čech from @iocbprague.bsky.social and Cesnet on usegalaxy.cz

1st @elixircz.bsky.social PhD conference at Telč on 27-28th March 2025 superthread.

third session of 1st @elixircz.bsky.social PhD conference will focus on structural bioinformatics

we continue 1st @elixircz.bsky.social PhD conference (I should made a hashtag - too late) with student presentations

1st @elixircz.bsky.social PhD conference just started with @majek.bsky.social invitation

4/5 prof

Everything comes to an end but memories remain!! We had a great 3DSIG/3DBioinfo event in "sunny" Barcelona this week!! I have enjoyed so much to help organising it & to have such great minds all together sharing science for 3 days!! Aufwiedersehen friends! For more science & friendships to come! ⭐

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New starter pack: go.bsky.app/8g64qRL

Mike spotted this before the rest of us. 🫡 Publications from 2025 are shared more on Bluesky than on X/Twitter.

oligomeric #Alphafoldology preprint

Randall never seen sunlight... Sad. :o( On the other side, he has seen empirically quite a lot planets in the night... Jealous.

Semen Yesylevskyy from Receptor.AI and @iocbprague.bsky.social speaks on @fchupol.bsky.social Scientific seminar about whether AI will replace molecular docking - you can see it here: www.youtube.com/live/gvc4Oen...

no, je fakt, ze cast ctvrti za ctyrproudovkou jako by k Hejcinu ani nepatrila…

Nejlepší způsob jak oslavit #10letELIXIRCZ infrastruktury @elixircz.bsky.social je začíst se do nového @vesmir.bsky.social se speciální obálkou

@elixircz.bsky.social has 10 years!

nice #Alphafoldology update of domains additions to AlphafoldDB

Provedeno. Tohle bylo šílené.

Viděl jsem pár videí z dnešního setkání z Oválné pracovny, jdu pro kreditku a nakupovat. Neuvěřitelný, co se tam dělo. Zelensky je borec a respekt Ukrajincům. www.dronynemesis.cz/en

Predictomes #Alphafoldology curated binary complexes using SPOC classifier

ROCKET #Alphafoldology fitting to lowres CryoEM to get conformation along the way

All-atom fixed backbone protein sequence design with FAMPNN @richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social www.biorxiv.org/content/10.1...