I don’t think challenging someone to the MOCA is the flex he thinks it is. A digit span competition on the other hand…

I made signs expressing points of disagreement with the government

Menthol cigarettes for AD? Surprisingly cholinergic effects of nicotine have a more established plausible mechanism. 🤓

When political theory catches up to neuroscience(re: PTSD, conditioning, empathy networks, psychopathy, just to start) political violence will have less support. Rage and trauma and desensitization multiply to disastrous end. Such cycles are hard to stop in individuals and societies alike.

He and Marshall Allen are still carrying the torch from a generation of musicians that still bring so much light to the world. To many more. ❤️ 🎂 🎈 🎷

US health insurers are raising insurance premiums by the most in 15 years. Recall that Trump recently threatened 250% tariffs on pharmaceuticals. GOP lawmakers also chose not to extend the expanded premium tax credits that expire at the end of this year

At Northwestern Medicine, Super Agers are defined as people aged 80+ with delayed word recall raw scores at least equal to people 20-30 years younger. With 25 year follow-up, what do their brains looks like at post-mortem? alz-journals.onlinelibrary.wiley.com/doi/full/10....

A nice write up on our longstanding Super Ager study, which helped to popularize the term, but more importantly, is yielding fascinating insights into resilience in aging. www.nytimes.com/2025/08/07/w...

After feeling like garbage for the past week with the fluctuations in air quality, I never knew how acutely and profoundly poor air quality could impact my wellbeing. It is a new dystopian yearly phenomenon in Chicago. Still we are lucky here, more resilient to climate change than others.

“I don’t think I’ve seen a more dangerous decision in public health in my 50 years in the business,” said Mike Osterholm, a University of Minnesota expert on infectious diseases and pandemic preparations.”

A very nice interview with my colleague, Dr. Ian Grant, on the topic of GLP-1 inhibitors and dementia. It’s so rare that journalists publish long form interviews instead of talking points. Take a listen! @nmneurology.bsky.social @wgntv.com wgnradio.com/john-landeck...

To describe those who fall pray to mass delusion, it’s no longer “drinking the kool aid” it is henceforth known as “drinking the orange juice”.

1/3 It's official, our grants from the NIH/NIEHS have all been suspended. We were aiming to understand how arsenic, a chemical that millions of Americans are exposed to at high levels, is disrupting the epigenetic machinery.

Henceforth my poor spelling, no longer a failing, shall be considered a tender mark of a genuine human creation. Evidence that no LLM was used in this writing. ✍️

First time in Canada and couldn’t imagine a better reason than for #AAIC2025! Find me during the conference walking around in my purple ISTAART Ambassador shirt or at my poster on Sunday. Drop by or reach out if you want to connect! 🍁🧠💜

Last year, our free 24/7 Helpline (800.272.3900) answered over 223,000 calls and online chats. This impact is possible because of YOU💜 See how you’re helping advance Alzheimer’s research, care, support and advocacy 👉 alz.org/about/our-impact #ENDALZ

He lived a public and courageous battle with Parkinson’s disease, other conditions. The fact that he performed so recently to a stadium of loving fans should be an inspiration to many with chronic illness. Rest in peace to the Prince of Darkness 🦇 ⚰️ 🎸 🤘

Finally: Ecologically valid MRI studies. Seen at Max Planck Campus of Cognition #noai

Fix This Sign xkcd.com/3113/

Make Subacute Sclerosing Panencephalitis Great Again! (MSSPEGA)

An important lesson for clinicians and caregivers, where you find the humanity you will find light. People with dementia have the same basic joys and fears as the rest of us. Humor, love, nostalgia, beauty are powerful tools.

I got permission to share this, and I'm extremely grateful for that. The Onion got this letter from one of our subscribers in Alaska. She works with dementia patients and decided to leave a copy in the car for each one. This email made my year. Read it and you'll see what I mean. People are good.

Our new paper is out in Science. We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change. Congrats to Bin for the great thesis, and the team! www.science.org/doi/10.1126/...

"But I am blown away by how much we have learned about Alzheimer’s over the last couple of years."—Bill Gates www.statnews.com/2025/06/17/b... "This is the moment to spend more money on research, not less." Agree 💯 erictopol.substack.com/p/predicting... erictopol.substack.com/p/the-breakt...

This is a good piece (gift link) on how the federal government ghosting Northwestern on congressionally-appropriated funding for three months is affecting the university...and will affect medical research more broadly.

🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏 *squinting* We had more people at the Lincoln Memorial for our Stand Up for Science rally on March 7th! #StandUpforScience #FailedBirthdayParade

yep! unpaywalled:

More complete analysis of NIH outlays (or lack thereof) from grant-watch.us grant-watch.us/posts/trends...

I am profoundly grateful and humbled to be among the other inspiring researchers chosen for this award. The SAMBA: Study of Anti-amyloid Monoclonal antibodies and Biospecimens in ARIA aims to elucidate the mechanisms of potentially harmful side-effects of new AD treatment. Excited to get started!

Our goal is to have 1000 SUFS Teach Ins across the US, by 9/30. *GASP* 😮 We know, it's a big goal. If you've received tax dollars for your science, you have a responsibility to inform *your* community what is at stake: public health, the economy, innovation, and America's global leadership.

🤷 Sorry guys.

MAHA wants raw milk raw milk can carry enterohemorrhagic E coli (EHEC) EHEC can cause microangiopathic hemolytic anemia (MAHA) MAHA yearns for the MAHA

We and other blacklisted Universities are reporting 0 dollars given from the NIH in April. Having lobbied for the AAN a few times, each time we were told what strong bipartisan support biomedical research funding had. Hope to see more courage from the GOP in coming weeks. Silence is cowardice.

People like the Anthropic CEO, even Bill Gates say AI can replace doctors within a decade. It took us many years just to install Epic. And the bloated tech industry with their infinite money hasn’t even solved spell-check. Give me a break. Totally delusional.

Scientists say the evidence linking climate change to individual companies' emissions is now strong enough to stand up in court.

It would be very healthy for human species, If there is less Discouragement.

It would be scientifically catastrophic to end this decades long study with 42k women continuing to be followed up, providing unique opportunities to learn new insights into women’s health and characterize risk of many health ailments including chronic disease www.science.org/content/arti...

🙏 We need your help 🙏 The government continues to cancel grants at both NIH and NSF to censor science it doesn't like. We're tracking terminations to organize and advocate. Please report your terminated grants: NIH: forms.gle/J2znQ7y7YpeP... NSF: airtable.com/appGKlSVeXni... w/ @noamross.net

University of Washington’s Alzheimer’s Disease brain bank hangs in the balance. It is preserving more than 4,000 brains for research. #Alzheimer #Brainbank #neuroskyence

A benchmarking crisis in biomedical machine learning www.nature.com/articles/s41... 🧬🖥️🧪

Been using AI to transcribe clinic notes, it helps efficiency a bit but there are nuances in cognitive visits that it does poorly with. Im finding it regularly transcribes incorrect information provided by people with no insight. Has no idea who is the reliable historian in the encounter.

ICYMI: New online! Microglia underlie amyloid-β clearance in immunized people with Alzheimer disease

When biomedical science and global health face existential threat, by @daltmann.bsky.social @angierasmussen.bsky.social @natrevimmunol.bsky.social www.nature.com/articles/s41... "The attack on some of us is an attack on all of us, and we must stand together."

Bill Gates has stated he thinks AI will replace doctors in 10 years, meanwhile Microsoft Word can’t even get formatting and spell check right decades after its release… and he’s one of the most grounded tech moguls.

Donanemab appropriate use criteria just came out. Praying insurers may note the recommendations for the new titration schedule, esp for high risk patients. Dumb and reckless to make patients pay out of pocket just to be safer. Waiting for FDA is a fool’s errand. www.sciencedirect.com/science/arti...

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵

Gift link. www.theatlantic.com/health/archi...

Congrats to the whole Abrams Research Center, especially Lynn, on this tour de force, uncovering the immune mechanisms of amyloid clearance and ARIA. Proud to be a part of it and excited to see where this takes us in the new era of disease-modifying therapy for AD. idp.nature.com/authorize?re...

Another unvaccinated child dies from measles, a fully preventable disease, and only the second child to die from measles in the US in the past 22 years