This project of early-career biologists curating and commenting on preprints looks cool. prelights.biologists.com/about-us/

Looks like groups outside the scientific community are commenting in higher numbers Day 18: 35,323 total comments, 17,458 mention science, 19,135 mention research

Really excited about this work with the awesome Will de Cothi & @shipleysj.bsky.social, out in Nature Reviews Neuroscience. We propose acetylcholine is an analogue of dopamine — tracking not reward prediction errors but state-transition prediction errors. https://doi.org/10.1038/s41583-026-01058-w

Instead of giving clicks to the #1 Newspaper that supported the invasion of Iraq, maybe look at this article about how dangerous American pickup trucks are by my lovely co-host, who never once laundered the American invasion of Iraq

Important preprint on the risks of ibogaine in clinics (19,071 patients, 11 clinics): all 6 deaths within 72h were in opioid-detox patients, 0 among 8,689 non-SUD patients, supporting the idea that risk clusters in opioid detox not the TBI/PTSD indications. www.researchsquare.com/article/rs-9...

If you developed a drug that successfully slowed human aging, how would you actually get it approved by the FDA? Here are my notes on what the FDA signaled at the recent Reagan-Udall Foundation meeting. www.linkedin.com/pulse/roadma...

Science mystery! Nearly everyone, everywhere, veers left when walking. Why??? www.nytimes.com/2026/06/10/s... @nytimes.com

Steve Cohen (TN-9) yesterday introduced the Controlled Substances Act (CSA) Clarification in Sciences Act to update the 1970 CSA, which is greatly needed. Text is not yet available but will be here www.congress.gov/bill/119th-c...

I wrote about the new rule proposing political oversight of every form of federal grant-making and what it means, legally, for OMB to do this. Wild it's gotten nearly 5k comments in < a week. Thanks to Carrie Wolinetz, @cdelawalla.bsky.social for their insights cen.acs.org/policy/resea...

OMB has proposed a sweeping overhaul of how federal research grants are awarded, terminated, and funded. I just posted my planned comments on LinkedIn in the hope it will make it easier for others to submit their own comments. www.linkedin.com/pulse/ombs-p...

Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)

Science Needs 3rd Spaces We envision scientific third spaces as “collaborative hubs where researchers, artists, engineers, and practitioners co-develop methods, share resources, and pursue projects driven by curiosity". authors.elsevier.com/sd/article/S...

Going through an issue of the TLS from last December, I find a philosophy pun courtesy of Nigel Warburton that surely deserves wider currantsy.

Do you think that the canonical cortical circuit is complicated? It's so much worse than that! Overlayed on top of the wired connectome, there are *18* different signal-carrying peptides in cortex! Their range is ~similar to the size of a cortical column elifesciences.org/articles/47889 1/

I don't necessarily disagree with the conclusions but I'm very surprised they aren't reporting rate pressure product, the conventional surrogate for myocardial oxygen demand. My guess is this will change a bit in review. www.medrxiv.org/content/10.6...

So entropy isn't a great index of psychedelic fx, DMN isn't selectively disrupted by psychedelics (see last post), & psychedelics don't selectively facilitate bottom-up processing (there are several references on this I'd be happy to share), so what's left for EBH/REBUS? 10/10

Selecting an effect size for power analysis is hard. Many researchers fall back on Cohen's thresholds, but they have no empirical basis and vary wildly by field. Our new paper offers a better option: field-specific effect size distributions built from meta-analytic data doi.org/10.3758/s134...

Excited to share an early look at psilo-seq, a web portal for exploring our lab’s single-nucleus RNA-seq data in mice following psychedelic treatment.

First time I've ever saved a post

What patterns can chemistry grow when left to organize itself? I got "chemical gardens" at home, with mineral “plants” blooming inside a flask as self-organizing worlds emerging from simple ingredients. Inspired by: www.damtp.cam.ac.uk/user/gold/pd... @leecronin.bsky.social @marktas.bsky.social

I'm looking for a post-bac research assistant to help run our studies on the impact of psychedelics on memory! Preferably with an interest in cognitive neuroscience (not just psychedelics or clinical research) and knowledge of coding/data analysis. utaustin.wd1.myworkdayjobs.com/UTstaff/job/...

Real-world data reveal that cooperation continually falls and rebounds. Motivation to cooperate must therefore be actively renewed rather than assumed to sustain itself go.nature.com/4tvFx7I

Been wondering how long the DEA would get to stall on this. Good stats are hard to come by but the estimate is 40% of drug arrests are for cannabis possession. Few of these are federal cases and states have their own drug laws, so these good steps do not automatically help vs local injustice.

My thoughts on why there were so many AI companies announcing biotech projects this month: www.linkedin.com/pulse/why-bi...

R/Medicine Hackathon is tomorrow! Focusing on the {teal} package, a framework for building interactive exploratory data analysis applications in clinical trials. Beginners welcome, registration for R/Medicine required. Sign up, prep, and all the deets here: rconsortium.github.io/RMedicine_we...

The "Version of Record" of my paper with Mike Woodford is finally there. I am very glad with this paper that points to new laws of psychophysics, which we derived from a carefully considered principle of endogenous efficient coding.

Had a great time today talking transportation with @jeffreytumlin.bsky.social, Darwin Moosavi, and @francessawyer.bsky.social. Big takeaways: - SAVE TRANSIT by voting yes on the two Bay Area transit measures - Policy is personnel: focus on office-holders, not just projects or policies

Now that it has been out for a week, I thought I’d address a few strange takes regarding our recent mega-analysis on the effects of psychedelics on brain function (specifically, resting-state functional connectivity). 1/15 www.nature.com/articles/s41...

Looking forward to this book on Sol Snyder: bookshop.org/p/books/the-...

Posted some thoughts on Otsuka's acquisition of Transcend over on the ol' Linke Din. www.linkedin.com/pulse/otsuka...

One of the many weirdnesses of today: AI writing's overuse of certain rhetorical tools is giving them a metallic skunk. For those of us who like writing and reading, it adds an unfortunate adversarial aspect, like Garner's idea of skunked words. thebettereditor.wordpress.com/2011/11/28/w...

For those interested in the history of psychedelic research… I wrote a narrative piece describing studies of psychedelic effects on serotonergic neurons in the dorsal raphe, from late 1960s to 1980s: journals.sagepub.com/doi/10.1177/...

This preprint is about this! THIS!! Mindblowing.

Hungary has chosen Europe. Europe has always chosen Hungary. A country reclaims its European path. The Union grows stronger.

I’m talking about how LSD testing in 1950s Saskatchewan, Canada revolutionized thinking about madness and mental illness at this free hybrid conference at the end of April.

🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵 www.medrxiv.org/content/10.6...

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

Congratulations to the team at Transcend on this well‑deserved outcome! psychedelicalpha.com/news/breakin...

AtaiBeckley just announced positive Phase 2a results for EMP-01 (R-MDMA) in Social Anxiety Disorder: 49% CGI responders vs 15% placebo, 11.85-point placebo-adjusted LSAS reduction after just two doses over six weeks. Small trial, but looks like a signal. ir.ataibeckley.com/news-release...

There's a lot to say about this study. Here are a few thoughts in fairly random order. To start with: The study provides evidence that the therapeutic value of MDMA is shared by the broader class of entactogens, including molecules where high exposures do not chronically lower serotonin.

Phase 2 results for TSND-201 (Methylone) for PTSD jamanetwork.com/journals/jam...

Among other interesting topics, the new Psychedelic alpha touches on the recent fatalities during ex-US ibogaine treatment. psychedelicalpha.com/news/p%ce%b1...

Vivaldi is my main browser on mobile. I recommend it.

Great work

Here, again, is a feed of all the Democratic members of Congress. bsky.app/profile/did:...

One third of SF without power rn pgealerts.alerts.pge.com/outage-tools...

Trump just officially signed off on moving cannabis to Schedule III

For those looking for a new browser, I'm happy with Vivaldi. vivaldi.com/for-a-better...

(all of us)