There's a lot to say about this study. Here are a few thoughts in fairly random order. To start with: The study provides evidence that the therapeutic value of MDMA is shared by the broader class of entactogens, including molecules where high exposures do not chronically lower serotonin.

A great new preprint on the importance of pilot studies for the validity of studies that are performed. Such an important tooic, that is discussed too little. I especially liked the section on the need for transparent reporting. osf.io/t968e_v1 By @yashvin.bsky.social and collaborators.

Phase 2 results for TSND-201 (Methylone) for PTSD jamanetwork.com/journals/jam...

One of the more thought provoking studies I've read recently. Suggests volume of preparatory sessions before psychedelic dosing are more relevant to reducing depression symptoms than volume of integration sessions after a dose.

Historian of medicine here. Yes. Yes, they did.

I would support AOC running for President, but I’d rather she spend the next 40 years as Speaker of the House.

🧵 First clinical trial ever conducted in a state-regulated psychedelic program just published. Oregon's psilocybin program has served 20,000+ people but the majority are wealthy out-of-state travelers. This study targeted low-income participants to test feasibility. #psychedelicscience

Very excited to post our paper led by @daburke.bsky.social www.nature.com/articles/s41... where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

The big consciousness conference in Tucson/Arizona is cancelled. Philosophy & Cognitive Science are fields long known to be largely inside-handshake dudebro clubs, something which I said out loud (it's not that they'd hired me), and now revealed to be disproportionally present in the Epstein files.

Very happy to share a new paper in @npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.

Among other interesting topics, the new Psychedelic alpha touches on the recent fatalities during ex-US ibogaine treatment. psychedelicalpha.com/news/p%ce%b1...

"Blunted Psychedelic Drug Effects in Older Adults", coauthored with @robincarhartharris.bsky.social and Kevin Boehnke, is out now in the American Journal of Geriatric Psychiatry.

It seems that cancer has a preventative effect on Alzheimer's - but turning that phenomenon into something useful is not going to be straightforward:

Hi folks! For a methods validation paper, we're looking for a large, cross-sectional, psychometric dataset that will show considerable heterogeneity in item responses, preferably, based on different classes/clusters/groups of people. Open access optimal, but if you have one you'd share w me ...

New review paper led by @lucyfoulkes.bsky.social: Mental health awareness campaigns reduce stigma but can also lead to problematic self-diagnosis and symptom misinterpretation. These trade-offs matter, especially for adolescents. www.nature.com/articles/s44...

In 2025, departures of govt scientists outnumbered new hires by a ratio of 11 to 1. This reduction in STEM PhDs translates to 106k yrs of federal work experience across 10,000 employees. These talents will take their expertise elsewhere. Experience is indispensable. 🧪 www.science.org/content/arti...

"It may take time to prove you're right, but you have to stick to it." - Fred Korematsu Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/

it's easy to create custom feeds for bluesky based on regular expressions, here's an attempt for rhythms in the brain: bsky.app/profile/did:... feeds with a curated user list amplify often the same high-profile posters, I feel this maybe has a better chance of catching more obscure content.

Vivaldi is my main browser on mobile. I recommend it.

Great work

Collaborative groups often outperform single individuals in complex problem solving. A new paper examined how to create the right incentives to promote this kind of collective intelligence. www.pnas.org/doi/epdf/10....

@zoedubus.bsky.social Well done! You can hear Zoe's presentation at the Touch with Substance conference with the replays at unwindlearning.com @scipsychedelics.bsky.social

Every time I talk to someone outside of Minnesota, we always spend time on *really* basic things they have don’t understand about what is happening here. So let’s do a Q&A. What are your most basic questions about what’s going on in Minnesota?

This Thursday at noon. Join us (over Zoom) for the MIT Consciousness Club. George Mashour (University of Michigan Medical School) - "Consciousness and the Dying Brain" sites.google.com/view/mit-con... #neuroscience

An interview by Nick Dirks from New York Academy of Science about medical anthropology and psychedelics. www.nyas.org/ideas-insigh...

Here, again, is a feed of all the Democratic members of Congress. bsky.app/profile/did:...

I’m facilitating the rehoming of two sweet cats who belonged to a friend who recently passed unexpectedly. They deserve a stable place to land. 2-3 year old bonded pair, one male one female. Please send me a DM if you have the interest and ability to care for these sweet voids. Located in Oakland.

IT FINALLY HAPPENED I AM ON A PLANE WITH A BABY WHO SAYS “HI” TO EVERYONE AS HE GOES DOWN THE AISLE

One third of SF without power rn pgealerts.alerts.pge.com/outage-tools...

Trump just officially signed off on moving cannabis to Schedule III

For those looking for a new browser, I'm happy with Vivaldi. vivaldi.com/for-a-better...

For those looking for a new browser, I'm happy with Vivaldi. vivaldi.com/for-a-better...

Have any of my academic friends applied for the ARPA-H EVIDENT program? If so, I’d love to chat with you for a story I’m working on about how it could impact the industry. Feel free to DM or reply to this post!

🐁 Very concerning finding: Psilocybin promotes brain tumour growth Authors caution against use of 5-HT2A agonists like psilocybin in patients with glioma, "given the profound and sustained tumor growth-promoting effects observed." Extends to other serotonergic drugs like LSD.

Bluntly, Section 230 is almost literally the law that the entire internet rests upon, it makes it possible for user generated content to exist on the internet, it’s incredibly important, and genuinely we must defend it at all costs. This place literally would not exist without it.

New study challenges the idea of a unified decision network: Neuropixel recordings in primate OFC showed robust encoding during value-based choices but near-silence during perceptual decisions, even when rewards are at stake. #RewardSignals #neuroskyence www.biorxiv.org/content/10.1...

Asking for some help. I'm working with someone who is designing a pilot to study the uptake of PFAS chemicals by mushrooms for purposes of remediation. Does ANYONE have a contact for a mycologist or someone who knows about mushrooms? If so, can you point them my way? Many thanks.

The Psychedelic Practitioner Issue 2: Preparation We explore the science and practice of psychedelic preparation through interviews, research reviews, and practitioner insights. Read now: psychedelicalpha.com/news/the-psy...

Check out this awesome new preprint which assessed mental health outcomes over four years (!) in groups of adult and adolescent cannabis users (and non-using controls): osf.io/preprints/ps...

A lot of interest in PET imaging of synaptic markers in humans after psychedelics. This preprint from Knudsen lab may be the first. People treated in therapeutic-like setting had more intense experiences and greater increases in synaptic density than those dosed in MRI scanner. tinyurl.com/36vv6a9v

(all of us)

New on the Archive: Simons, Massimiliano (2026) What is the history of philosophy of experimentation a history of? The cases of Hugo Dingler and Gaston Bachelard. HOPOS: The Journal of the International Society for the History of Philosophy of Science. https://philsci-archive.pitt.edu/27380/

Check out a new article out now from DDRU Director, M. Baumann & colleagues regarding transporter activities of prolintanes. "Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences" www.sciencedirect.com/science/arti...

The great Erik Davis on the War on Empathy substack.com/app-link/pos...

Q&A with Tricycle Day in which we cover the impact of psychedelics on memory and creativity, as well as a concussion I had that led to my interest in memory. Henry is such a great interviewer and resource for distilling science! www.tricycleday.com/p/manoj-doss

"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se

Let's compare our world models. I find that different people seem to have rather distinct internal world models. E.g. I personally have neither visual imagination nor an inner voice, found it weird others do. Here is a quick google forms to check idea: docs.google.com/forms/d/e/1F...

Congratulations to Harriet De Wit, Ph.D., for being awarded the Barbara Fish Memorial Award! ☺️ #ACNP2026 Please click here ➡️tinyurl.com/2ndexz5k#ACNP2026to watch the nominator video by Abraham Palmer, Ph.D.