Real-world data reveal that cooperation continually falls and rebounds. Motivation to cooperate must therefore be actively renewed rather than assumed to sustain itself go.nature.com/4tvFx7I

Been wondering how long the DEA would get to stall on this. Good stats are hard to come by but the estimate is 40% of drug arrests are for cannabis possession. Few of these are federal cases and states have their own drug laws, so these good steps do not automatically help vs local injustice.

My thoughts on why there were so many AI companies announcing biotech projects this month: www.linkedin.com/pulse/why-bi...

R/Medicine Hackathon is tomorrow! Focusing on the {teal} package, a framework for building interactive exploratory data analysis applications in clinical trials. Beginners welcome, registration for R/Medicine required. Sign up, prep, and all the deets here: rconsortium.github.io/RMedicine_we...

The "Version of Record" of my paper with Mike Woodford is finally there. I am very glad with this paper that points to new laws of psychophysics, which we derived from a carefully considered principle of endogenous efficient coding.

Had a great time today talking transportation with @jeffreytumlin.bsky.social, Darwin Moosavi, and @francessawyer.bsky.social. Big takeaways: - SAVE TRANSIT by voting yes on the two Bay Area transit measures - Policy is personnel: focus on office-holders, not just projects or policies

"In the first major case in which the Court granted emergency relief as a means of shaping nationwide policy, it turns out that the justice who led the charge was the one who was doing quite a bit more than calling balls and strikes." Me on Saturday's @nytimes.com scoop in today's "One First":

Now that it has been out for a week, I thought I’d address a few strange takes regarding our recent mega-analysis on the effects of psychedelics on brain function (specifically, resting-state functional connectivity). 1/15 www.nature.com/articles/s41...

Looking forward to this book on Sol Snyder: bookshop.org/p/books/the-...

Posted some thoughts on Otsuka's acquisition of Transcend over on the ol' Linke Din. www.linkedin.com/pulse/otsuka...

One of the many weirdnesses of today: AI writing's overuse of certain rhetorical tools is giving them a metallic skunk. For those of us who like writing and reading, it adds an unfortunate adversarial aspect, like Garner's idea of skunked words. thebettereditor.wordpress.com/2011/11/28/w...

For those interested in the history of psychedelic research… I wrote a narrative piece describing studies of psychedelic effects on serotonergic neurons in the dorsal raphe, from late 1960s to 1980s: journals.sagepub.com/doi/10.1177/...

This preprint is about this! THIS!! Mindblowing.

Hungary has chosen Europe. Europe has always chosen Hungary. A country reclaims its European path. The Union grows stronger.

I’m talking about how LSD testing in 1950s Saskatchewan, Canada revolutionized thinking about madness and mental illness at this free hybrid conference at the end of April.

🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵 www.medrxiv.org/content/10.6...

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

Congratulations to the team at Transcend on this well‑deserved outcome! psychedelicalpha.com/news/breakin...

AtaiBeckley just announced positive Phase 2a results for EMP-01 (R-MDMA) in Social Anxiety Disorder: 49% CGI responders vs 15% placebo, 11.85-point placebo-adjusted LSAS reduction after just two doses over six weeks. Small trial, but looks like a signal. ir.ataibeckley.com/news-release...

There's a lot to say about this study. Here are a few thoughts in fairly random order. To start with: The study provides evidence that the therapeutic value of MDMA is shared by the broader class of entactogens, including molecules where high exposures do not chronically lower serotonin.

Phase 2 results for TSND-201 (Methylone) for PTSD jamanetwork.com/journals/jam...

Among other interesting topics, the new Psychedelic alpha touches on the recent fatalities during ex-US ibogaine treatment. psychedelicalpha.com/news/p%ce%b1...

Vivaldi is my main browser on mobile. I recommend it.

Great work

Here, again, is a feed of all the Democratic members of Congress. bsky.app/profile/did:...

One third of SF without power rn pgealerts.alerts.pge.com/outage-tools...

Trump just officially signed off on moving cannabis to Schedule III

For those looking for a new browser, I'm happy with Vivaldi. vivaldi.com/for-a-better...

(all of us)

The great Erik Davis on the War on Empathy substack.com/app-link/pos...

Artists' Television Access, the great San Francisco all-volunteer, artist-run, underground and experimental media arts gallery needs help making rent and securing its future. www.every.org/ataconnect/f...

Interesting preprint of a study of psilocybin and 2C-B that uses reinforcement learning models to estimate Self-Other distinction changes during a probabilistic false-belief task www.medrxiv.org/content/10.1...

The Billionaire, the Psychedelics and the Best-Selling Memoir Amy Griffin wrote a book based on recovered memories of childhood sexual abuse. Oprah Winfrey and a slew of celebrities promoted it. Then questions arose. www.nytimes.com/2025/09/24/n...

"Neural responses correlated with impending motor action almost everywhere in the brain. Responses to reward delivery and consumption were also widespread."

Innovative fabrics, relaxed drama, infinite drip. RIP Giorgio Armani.

FDA just released an interesting dataset of Complete Response Letters issued in response to _approved_ NDAs and BLAs between 2020 and 2024. open.fda.gov/apis/other/a...

Farewell to Jonathan Ott, opinionated ethnobotanist and scholar of entheogens, a word he helped create. His book Pharmacotheon remains a must-have for any serious psychedelic library. lucys-magazin.com/r-i-p-jonath...

Gofundme for Betty Cantor-Jackson, who made all those amazing soundboard recordings of 70s-era Grateful Dead shows, including Cornell '77. These are cultural-heritage-level relics. Please consider sending her a few bucks if you can spare them. gofund.me/dc8133fb

May be obvious to half of you, but the small hands stereotype that the NYT just published is part of an (insidious) process of framing specific manufacturing jobs as feminine and unskilled, just something young Asian women are 'naturally suited for' and thus not requiring as much pay or break time.