Digital chemistry won’t just happen by bolting a chatbot to a liquid handling robot. It needs a fundamental new approach to allow the programming of matter, or chemputation. The theory & practical implementation is outlined here: arxiv.org/abs/2408.09171

www.technologynetworks.com/informatics/... #chemputation #digitalchemistry

Chemputation will lead to an exponential growth of the number of molecules synthetically accessible. It transcends the limits of manual labor by using a Turing-like ontology for error correction to ensure we can go deeper into chemical space. arxiv.org/abs/2408.09171

AI is showing us that creativity sits in an entirely different category to data retrieval.

Chemputation is universal.

So we opened the worlds first Chemifarm today! www.chemify.io

Now in 2025, Chemify is opening the worlds first Chemifarm, which is the first commercial facility for chemputation able to do chemical design, discovery, & manufacture on demand. www.chemifyx.com

Making digital chemistry truly universal for chemputation (digital control of chemsitry) required a new approach to hardware, wetware, & software with the development of XDL. www.science.org/doi/10.1126/... Now the theory showing universality is done. arxiv.org/abs/2408.09171

In 2012 I had a dream of universal digital chemistry for chemputation inspired by 3D printing technology. By 2016 we made a key advance. We went from a vision to a universal code for organic synthesis - in this case making Ibuprofen in a hacked 3D printer. www.beilstein-journals.org/bjoc/article...

This helps redefine what a molecule is & that blows my mind. arxiv.org/abs/2408.09171

Want to know why Chemputation redefines the very concept of what a molecule is? Updated preprint arxiv.org/abs/2408.09171

Well we know what molecules are according to the text books, but do we know what Molecules are according the theory of Chemputation…this is coming soon (Molecules from molecules is a play on Humans from humans by @aptshadow.bsky.social).

Just finished redefining the idea of a molecule using assembly theory. Will preprint soon.

SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web. chemsymposia.com

The ghost of computation makes us believe that computation is fundamental. There is no physical basis for this. Computation is a human construct

Chemputers can be programmed using our chemical programming language (XDL) to make molecular machines. Great work by the team dlvr.it/TJsSjt Video done in collaboration with SciCommStudios.

To solve intelligence you need to solve life, to solve life you need to solve the origin of life. Assembly theory aims to make progress across the board but progress is not guaranteed.

Academia is under attack by the tech bros, which is hilarious because all their ‘tech’ was invented in academia.

Critical thinking, freedom of speech, & freedom to disagree are hard won & should be hard won every single day. Don’t take them for granted with nonsensical isms.

Saturday night radioactivity.

Chemputers are Turing complete & this is going to accelerate chemistry dramatically. Chem/acc

Ridge surfing in Sedona.

It still blows my mind that it’s possible to measure molecular complexity spectroscopically. In a few weeks we will be releasing a new set of tools for chemists to explore molecular assembly spaces.

Assembly Theory is the only way to objectively measure the complexity of objects, systems, & phenomena. All other methods require assumptions which inject additional complexity into the data without normalisation which prevents a meaningful comparison.

Who says 3D printing drugs is impossible? Here is Morphine.

Proper sleep screen on my remarkable from the onion.

A proof that the assembly index problem is NP-complete is here: arxiv.org/abs/2406.12176 This also explains why the assembly index is not equivalent to other commonly used complexity measures including Shannon entropy, Huffman encoding & LZW. #AssemblyTheory

A proof that the assembly index problem is NP-complete is here: arxiv.org/abs/2406.12176 This also explains why the assembly index is not equivalent to other commonly used complexity measures including Shannon entropy, Huffman encoding & LZW. #AssemblyTheory

Academics are too scared to do ‘career ending’ or controversial research. Let’s encourage people not to be boring & support them. The future of humanity will depend on this to accelerate innovation. We must to be less boring even if it means being wrong! Just be less wrong…

the ghost in the machine is historical contingency

Can we use XDL like a real programming language to run a chemputer? Yes! Here we build & use reaction blueprints for chiral synthesis in a chemputer. www.nature.com/articles/s41... #chemputation

You can’t get meaning by just compressing data.

Why agree? Disagreeing in good faith is the only way to make progress.

There seems to be a mediocrity crisis.

I’m on both X and Bluesky. I find X raw & Bluesky rather elitist. As an academic anarchist I like to poke elitism. But I’m flawed so I apologise to everyone for the offence, on both platforms. 😂

Seen in a bookshop in silicon valley…

The idea that AI is suddenly going to wake up & be sentient is obviously wrong & those that peddle this idea are scammers.

This is important: x.com/glukianoff/s...

I conjecture that a universe with fixed initial conditions cannot support life.

As an experimentalist my theories are often incremental, limited but experiments I can imagine, & hopefully do in the lab. I have no deluisions, I just want to know how things work.

We explain why experimentally measured assembly indices are required to determine the threshold for life royalsocietypublishing.org/doi/10.1098/rs… addressing the misunderstanding that the calculation of the assembly indices of 'complex' objects is the same as measuring them experimentally.

Preprint on Assembly Theory and its Relationship with Computational Complexity, arxiv.org/abs/2406.12176 showing why AT is NOT equivalent to other measures e.g. Shannon, Huffman, LZW compression & prove why assembly index is not in the same complexity class as these algorithms.

I’ve just nailed the connection between Chemputation & von Neumann’s universal constructor. #chemputation

I admire those build theories with experiments in mind…

Critical thinking is fun. Don’t suppress it. Embrace the challenge.

If it were possible to exactly predict the future it would not be possible to change it, it is good we live in a universe that has some inherent non-determinism and our future is not determined until it happens

So what is computation? This is a non trivial question.

Congratulations to Robert Rauschen for passing his PhD viva. He is the 87 PhD student from the Cronin lab

Assembly theory analysis of Taxol with its assembly space.

Chemputation in the lab.