Paper out now in @natbiotech.nature.com by @yizhoudonglab.bsky.social describing new LNP mRNAs for combatting bacterial infections… helping the immune system clear the pathogens while limiting tissue damage…

Congratulations to Yonger Xue & Xucheng Hou for leading the wonderful work on peptibody mRNA! Thanks @miriammerad.bsky.social for the huge support! Thanks Rong Li @natbiotech.nature.com and reviewers for the amazing review process! Thanks @NIH @IcahnMountSinai!

Chemical strategies for brain delivery of genomic therapy, a very nice Perspective with @ericjnestler.bsky.social! Congratulations to Haoyuan, Changyue, and Tami! Thanks Nature Reviews Chemistry! Thanks NIH& @mountsinainyc.bsky.social! www.nature.com/articles/s41... rdcu.be/eRKLA

NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...

Comment of the day on the petition calling for a funding institute to elevate biomedical research across New York State! Sign & share!

The 2025 issue of @mountsinainyc.bsky.social's Science & Medicine magazine is now live! At this pivotal moment for health care, Mount Sinai fearlessly embraces its leadership role in medical education, scientific research & patient-centered clinical care. READ👉 scienceandmedicine.mountsinai.org/2025

📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...

We ❤️❤️❤️ New York State — but life here could be fairer and healthier for all. If you agree, sign up at www.nycures.org! 💔 Over 154,000 NYC public school students experienced houselessness last year. @sunyofficial.bsky.social estimates 8% of undergrads and 5% of grad students face housing insecurity.

Our latest work @mitkochinstitute.bsky.social is now published in @natnano.nature.com ! By optimizing lipid nanoparticle design, we significantly improved #mRNA expression and immune responses — paving the way for a new class of delivery systems for #vaccine. Free access - rdcu.be/eOLjb #biotech

🧬 mRNA has emerged as a powerful new class of therapeutic molecules—extending far beyond vaccines to cancer immunotherapy, protein replacement, and gene editing. 🧩 But designing mRNAs with strong, lasting protein expression remains a major challenge.

In @natchembio.nature.com, @yizhoudonglab.bsky.social highlights GEMORNA, an AI framework that directly generates mRNA & circRNA sequences by jointly modeling CDSs & UTRs, for coordinated optimization of expression and stability. An elegant tool to help design mRNAs! www.nature.com/articles/s41...

For readers interested in lipid nanoparticles for nucleic acid delivery, here's a perspective by Cullis and Feldner on the evolution of the field rdcu.be/eMpeO nature.com/articles/s41...

"The way forward has become very clear"- Dr. Brendan G. Carr A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!

With co-authors Bram Teunissen & @yizhoudonglab.bsky.social, we dive into emerging ways to make LNPs more precise—from tuning their chemistry to reprogramming RNA expression and even controlling protein stability & localization >>> a road🗺️ for more intelligent delivery & broader applications ahead.

The BIGGEST impact you can have with 1 minute today ⏱️ Add your name to show NY is ready for a statewide biomedical institute. CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York. ✍️ www.nycures.org/

🚨 AIMBE calls on the scientific community to urge Congress to ensure timely passage of the FY2026 budget 👇 Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath. takeaction.io/aimbe/protec...

PRESS RELEASE! @mountsinainyc.bsky.social receives $8 million grant from DataPhilanthropy to fuel research into #CADASIL This transformational grant will launch new Center led by Dr @fanny-elahi.bsky.social to pursue trtmnts for understudied neurovascular diseases👉 www.mountsinai.org/about/newsro...

📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...

💫Through the #SURP4US program, under the mentorship of @yizhoudonglab.bsky.social, Alister (Jia) Ng gained research experience & developed an interest in drug design & delivery. Inspired by her family's history w/ #Antidepressants; she aspires to pursue a career in pharmaceutical research.

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

🚨 Out now in @nature.com: it's time to de-Americanize global science. We need:🌍 Equitable funding 🔄 Shared governance 🔐 Resilient data infra🆘 Emergency support for scientists at risk. The next crisis can’t break global research again. Nova Medical School 🔗 rdcu.be/ewp6K

RNA chemistry and therapeutics www.nature.com/articles/s41... rdcu.be/ewkq0 This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties @yizhoudonglab.bsky.social

Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere. It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇 📖 www.nature.com/articles/s41... #SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social

ONLINE NOW! Neurosurgery & Neurology Special Report 2025. In this issue, Check Out "Mount Sinai Is Among First to Use Blood Tests as Early Detection Tool for #AlzheimersDisease and Related #Dementias in Patients". @fanny-elahi.bsky.social Learn More 👉 reports.mountsinai.org/article/neur...

We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international) We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc. Download this massive database here for free: research.jhu.edu/rdt/funding-...

Evolution-guided protein design of IscB for persistent epigenome editing in vivo - @zhangf.bsky.social @broadinstitute.org @hhmi.org go.nature.com/44XVBph

FRIDAY👉May 9, 2pm, DON'T MISS this #FriedmanBrainInstitute Special Seminar as hosts @ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette. LEARN about cutting edge research on #vascular disease & #VCID #CSVD done at Paris Brain Institute.

PRESS RELEASE | Mount Sinai researchers Arthur Godino, Marine Salery, @ericjnestler.bsky.social, et al. have discovered distinct roles for 2 dopamine receptors located on nerve cells w/in the portion of the brain that controls approach vs avoidance behavior. www.mountsinai.org/about/newsro...

@lizwaynephd.bsky.social @neuroamyo.bsky.social @brianaguado.bsky.social @cosgriffhernandez.bsky.social @kumarlabucb.bsky.social @willitslab.bsky.social @yizhoudonglab.bsky.social @troy-biomechlab.bsky.social @christmanlab.bsky.social @shuvoroy.bsky.social

🚨 AIMBE is calling on the biomedical research community to take a minute to send our 3 new advocacy letters urging Congress to: 1. Protect the STEM Training Pipeline (e.g., NIH MOSAIC, T32s, MARC, etc.) 2. Oppose Indirect Cost Caps 3. Support Research Funding in FY2026 aimbe.org/advocate/wri...

An exciting work on brain delivery via the meningeal lymphatic vessels (MLVs)! Thanks @NIH @NIGMS @sinaiimmuno.bsky.social @sinaibrain.bsky.social @ohiostatepress.bsky.social! pubs.acs.org/doi/10.1021/...

JOIN US & Icahn Mount Sinai in congratulating @ericjnestler.bsky.social for his election to The National Academy of Sciences. This great honor recognizes Dr. Nestler’s cutting-edge work on molecular basis of #DrugAddiction & #Depression & on advancing the field of psychiatry into the molecular era!

www.sciencedirect.com/science/arti... Great collaboration with Steve Schwendeman’s lab, showing effective local delivery of immune checkpoint blockers for brain cancer therapeutics @umich.edu @theabta.bsky.social

Research Saves Lives Without research - at Johns Hopkins and at thousands of other universities, medical schools and research institutions across the nation - scientific breakthroughs suffer and the lifesaving treatments of tomorrow are at risk www.jhu.edu

🧐 NEW mRNA LNP from @yizhoudonglab.bsky.social that supercharges the cancer-immunity cycle by inducing tumor cell death while increasing the number & activity of dendritic cells. Want to know how it works? Read the full paper in the Journal of Controlled Release www.sciencedirect.com/science/arti...

A major paper @nature.com this week found a significant decline in dementia after an outdated Shingles vaccine. I've reviewed the study and many other relevant ones here erictopol.substack.com/p/the-shingl...

After ‘coding error’ triggers firings, top NIH scientists called back to work | Science | AAAS www.science.org/content/arti...

If you or someone you know has been negatively affected by NIH-funded clinical trials being paused, disrupted, cancelled etc., I have a contact with the Senate HELP Committee eager to collect stories of everyday Americans affected by the NIH closures. Please DM me.

New paper from the lab: Accelerated discovery of cell-migration regulators using label-free deep learning-based automated tracking. 840 experiments done in 70h instead of 5.5 years! Read here: www.biorxiv.org/content/10.1...

New publication out in Digestive Diseases and Sciences in collaboration with @julienguyenlab.bsky.social “Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice” 🔗 link.springer.com/article/10.1...

Who would've thought you could play Bingo with posters? Introducing #PosterBingo for the Controlled Release Society Annual Meeting! Inspired by an idea #AssafZinger and his students had! See you in Philly! youtu.be/xMpxLsW-2QA?...

Congratulations @miriammerad.bsky.social on receiving the prestigious Sjöberg Prize medal yesterday for groundbreaking work on how innate immune cells influence the body’s ability to fight cancer. Her discoveries have opened new paths for cancer prevention and therapies. www.kva.se/en/news/sjob...

Carnage! www.thetransmitter.org/science-and-...

NOT TO MISS! On Tuesday, 4/29, join host @scottrussophd.bsky.social when he welcomes Dr. Hongzhen Hu, Scientific Director of The Mark Lebwohl Center for Neuroinflammation & Sensation, to the #BrainBody Seminar Series. @mountsinainyc.bsky.social Register Now 👉 mountsinai.zoom.us/webinar/regi...

Diana successfully defended her dissertation! We are so proud of you! Congratulations Dr. Kang!!!

A HUGE CONGRATULATIONS to @ericjnestler.bsky.social on being named Interim Dean of the Icahn School of Medicine! As we express great enthusiasm for Dr. Nestler becoming Dean & the exciting time ahead, please join us in thanking Dean Charney for his extraordinary service & commitment to Mount Sinai.