Saw this and grimaced

I got to say hello to @kencougr.bsky.social and @micoleermine.bsky.social, huzzah. It's been a really long time since I've seen them in person, so I was very glad I got the chance. 😊

Today's low-key furry shirt.

that checkpoint inhibitor drugs such as anti-PD-1 therapy -already used in hospitals- work best when they expand these stem-like and metabolically fit T-cells. In contrast, people whose immune reactions were regulated by exhausted cells fared badly. When checkpoint therapy was administered with

“stem-like" T-cells. These cells, characterized by genes TCF1 and LEF1, could self-renew and differentiate into new waves of fighters. If these cells were removed from mouse models, immune attacks collapsed; if they were grown, tumors disappeared and survival increased. Researchers also discovered

chemical messenger that recruits other immune defenses. The studies showed that metabolic flexibility, not target recognition, foretells how long the immune cells will keep fighting. Among the populations of tumor-infiltrating T-cells that were so diverse, one stood out as extraordinary: a subset of

glycolysis, they switched to oxidative phosphorylation and fatty acid metabolism- an energy strategy that enables them to endure the long term. When researchers boosted these channels of energy in mice, the T-cells killed tumor cells better and produced higher levels of interferon-γ, an immune

single-cell resolution, the researchers identified a minor subset of tumor-cytotoxic cells. These cells continue to function even in oxygen-starved, nutrient-poor environments in which other immune cells do not. These hardy T-cells employed a second fuel source. Instead of combusting glucose through

patients, the treatments fail because immune cells become exhausted. Tumors naturally adapt to disable or tire out the same cells meant to kill them. Researchers mapped how CD8⁺ T cells-the body's own killers-are capable of surviving and fighting within solid tumors. By examining the cells at

place. Taken together, the breakthroughs promise a day when the body's own immune system can prevent and fight cancer with greater accuracy and endurance. Cancer immunotherapy transformed the treatment of most cancers by unleashing the potential of the immune system to kill tumors. Yet, in most

In a breakthrough that could potentially rewrite the prevention and treatment of cancer, researchers have discovered how certain immune cells can break through tumors’ defenses. They have also developed a new nanoscale vaccine that shows promise in preventing cancers from occurring in the first

Melanoma, pancreatic cancer, and triple-negative breast cancer (TNBC) are each serious clinical challenges due to how common or aggressive they are and how poorly they often respond to treatment. Which is why researchers are determined to develop an effective treatment for all of them.

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types. NOTE: This is PRECLINICAL. • www.umass.edu/news/article... The study has been published in Cell. YES, it is PEER-REVIEWED. • www.cell.com/cell-reports... 🧪🧵⬇️

GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.

Hit the trail! 🪧 [ #art #designs ]

Snow day! I think this was my most widely-shared piece on the dead bird site. ❄ #art #animals

Butlerian Jihad incoming.

It's a tradition in Scotland for the road gritters too

They named the snowplows 🥹

Time for another #OldArtMonday Here is "Topher, the world's cutest otter" -- but giant. The pencils are from 1988 by @kencougr.bsky.social The inked image is from 1989 by Topher's creator Deal Whitley. Ken would have fun drawing people's characters giant with the byline "slightly altered."

It looks like Terrie Smith will need heart surgery for a leaky valve. She could use your support more than ever. www.furaffinity.net/journal/1125... She's currently posting colorized Havoc Inc. pages on her Patreon, consider subscribing or sending a donation. www.patreon.com/TerrieSmith

This dimwitted coward is taking on *Mark Kelly*? Space station commander combat tested Navy aviator Mark Kelly? 🍿🍿🍿🍿🍿🍿🍿

"How he does it!?" Hurray for cartoon Physics. Comment and Enjoy ^ ^

🏴󠁧󠁢󠁷󠁬󠁳󠁿🫡

Happy Caturday 🐈‍⬛🤍

A few beautiful things from The World Cheese Awards. Bern. Switzerland. 🇨🇭 🧀

a long time ago I made things 2x harder for myself but it was worth it

Is it me..or is it getting spicy in here? Toned commission that I absolutely upgraded to colored for the ever wonderful @spicysienna.bsky.social

Here is small otter. He is so small he’s probably still learning how to otter properly. Good luck, little otter!

My mother is very impressed with her friend’s elaborate cat Halloween costume, and in particular how detailed the feet and tail are. …it’s a fursuit but I’m not going to explain that.

I'm sorry, but Ford's "Don't criticize our cruise-control with lane-holding technology, a deaf driver might need it to sign to their passengers" ad is just the absolute worst kind of cripwashing I've seen yet.

"The rich behave the way they do not because they're sociopathic, but because they're strategic." Nope, sorry. If they "throw empathy overboard" as "a product the rich can't afford to have", they're sociopaths. I don't care what life journey brought them there. The rest of us can't afford them.

So when do the lawsuits start?

Sinclaire Sunday.

Damed useful information

Cats are liquid Especially on Halloween 🎃🐈‍⬛🎃

Free will rules

These ‘ghost flowers’ thrive without photosynthesis. One scientist is learning how | Science | AAAS www.science.org/content/arti... 🧪

So Pete Hegseth is getting gender affirming care while kicking highly qualified, highly trained trans service members out of our military? Got it.

Wow, those Epstein files must be really, really bad.

I will gladly draw all of the frogs as a symbol for the movement, explicitly to take them back from the fuckers who co opted Pepe for their nazi shit.

I should be adding the Grumpy Gryphon back onto my business cards

get this thing off my porch