Stephanie Kath-Schorr
@kathlab.bsky.social
📤 1343
📥 351
📝 13
Professor at University of Cologne, Germany. Organic Chemistry, Chemical Biology, Nucleic Acids
reposted by
Stephanie Kath-Schorr
Universität zu Köln
about 2 months ago
🧬🔬 A research team led by
@kathlab.bsky.social
has developed an artificial DNA base pair that works according to a new chemical principle. In contrast to natural bases, the novel artificial base pairs use halogen bonds that are enzymatically incorporated into DNA. Read more: ➡️
uni.koeln/AP4XF
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Artificial DNA base pair developed based on halogen bonds
A research team at the University of Cologne has developed an artificial DNA base pair that works according to a new chemical principle. In contrast to natural bases, the novel artificial base pairs u...
https://uni.koeln/AP4XF
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New paper in
@jacs.acspublications.org
🎉: A de novo designed unnatural base pair that exploits halogen bonding as pairing force in DNA for genetic alphabet expansion. 🧬 ⚗️
@unicologne.bsky.social
@chemunicologne.bsky.social
@breugstlab.bsky.social
pubs.acs.org/doi/abs/10.1...
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Investigating Halogen Bonds as Pairing Force in an Artificial DNA Base Pair
The past decades have seen significant expansion of the nucleic acid space with the development of modified artificial base pairs based on natural nucleic acid analogues and even entirely new designed base pairs. This expansion has led to tremendous potential for applications such as site-specific labeling and structural investigations. However, natural nucleic acids rely strongly on hydrogen bonding as the attraction force, which has driven the development of artificial base pairs that adapt this mechanism. To achieve orthogonality with natural bases, unnatural base pairs with alternative attraction forces, such as hydrophobic interactions, have been developed which however can perturb duplex structures. Our work introduces a completely newly designed artificial base pair that leverages halogen bonding (R–Hal···) as a directional hydrogen bonding-like interaction. We report computational studies that led to the development of this novel unnatural base pair and its synthesis. Our results demonstrate the successful acceptance of a bulky iodinated nucleoside triphosphate by KlenTaq DNA polymerase, enabling the selective enzymatic synthesis of a DNA strand containing the dIIPO–doIPP base pair. Our work presents the first demonstration of a novel base pair with halogen bonding potential that is enzymatically incorporated into DNA.
https://pubs.acs.org/doi/abs/10.1021/jacs.5c23044?trk=feed-detail_main-feed-card_feed-article-content
2 months ago
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Season’s greetings from
@kathlab.bsky.social
! 🎄✨ Grateful for a year of great science 🧪📄, strong teamwork 🤝, and shared moments 🚢🎉 - and excited for what lies ahead 🚀
@chemunicologne.bsky.social
@unicologne.bsky.social
4 months ago
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Excited to host all members of
@mechanism-network.bsky.social
for a full week of science 🧬 and networking 🤝 in Cologne! Great kickoff with Fredrik Westerlund introducing the MeChaNiSM MSCA DN🎓 Looking forward to a week full of
#nucleicacids
ideas 💡
@unicologne.bsky.social
@wilhelmssonlab.bsky.social
6 months ago
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Honored to share some big news: I’m now tenured as a W3 Professor of Organic Chemistry @UniCologne! Immensely grateful to all the group members who contributed to this journey🙏 — this milestone is ours to share. @ChemUniCologne
#OrganicChemistry
#Tenure
🍾🎉🧪🧬
7 months ago
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reposted by
Stephanie Kath-Schorr
ChemComm
9 months ago
New from our Pioneering Investigators collection 🎉 'Towards a hydrolysis stable artificial base pair with C-glycosides' by Stephanie Kath-Schorr (
@kathlab.bsky.social
) and colleagues.
#OpenAccess
🔓
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Towards a hydrolysis stable artificial base pair with C-glycosides
Artificial base-pairs expand the genetic alphabet and allow for site-specific labeling, for example with fluorophores or spin labels, thereby enhancing the capabilities of biomolecular sensing. We…
https://buff.ly/rcM38Wn
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reposted by
Stephanie Kath-Schorr
Michael Booth
10 months ago
The
#SCNAC2025
nucleic acid chemistry conference starting off in Czech-style by
@hoceklab.bsky.social
🧬🗡
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reposted by
Stephanie Kath-Schorr
Kerstin Göpfrich
10 months ago
#SCNAC2025
we are looking forward to hear about your thoughts on our RNA design tool
#PyFuRNAce
pyfurnace.streamlit.app
developed by
@monari-luca.bsky.social
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pyFuRNAce
Alt Text
https://pyfurnace.streamlit.app/
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Celebrating 75 years of
#FCI
@chemieverband.bsky.social
! 🎉 Grateful for the funding that supports the research of
@kathlab.bsky.social
including Julian Strippel and Matea Rabar.
@chemunicologne.bsky.social
🧬⚗️
11 months ago
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reposted by
Stephanie Kath-Schorr
RSC Chemical Biology
12 months ago
We’re pleased to announce our latest Emerging Investigators article collection, highlighting work from outstanding early career researchers selected from the chemical biology community. Discover this exciting work, all
#openaccess
and free to read, at
rsc.li/CBEMI24
.
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reposted by
Stephanie Kath-Schorr
TheGatherLab
about 1 year ago
Many thanks to all for this great collaboration pushing further the limits of microlasers - this time for DNA sensing. In particular to former
#HCNB
postdoc
@sorayacaixeiro.bsky.social
now at UBath and our friends from
@kathlab.bsky.social
in organic chemistry
@chemunicologne.bsky.social
.
add a skeleton here at some point
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🧬🔬New paper online: Nucleic acid sensing using DNA-functionalized whispering gallery mode microlasers! Great collaboration with
@thegatherlab.bsky.social
@sorayacaixeiro
@schubertlab.bsky.social
@chemunicologne.bsky.social
🧪
#DNASensing
#microlasers
pubs.acs.org/doi/full/10....
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DNA Sensing with Whispering Gallery Mode Microlasers
Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring, and molecular biology research by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on DNA-functionalized whispering gallery mode (WGM) microlasers. By correlating spectral shifts in laser emission to changes in the refractive index, we demonstrate real-time detection of DNA hybridization and structural changes. The addition of gold nanoparticles to the DNA strands significantly enhances sensitivity, and exclusively labeling the sensing strand or a hairpin strand eliminates the need for secondary labeling of the target strand. We further show that ionic strength influences DNA compactness, and we introduce a hairpin-based system as a dual-purpose sensor and controlled release mechanism for drug delivery. This versatile WGM-based platform offers promise for sequence-specific nucleic acid sensing, multiplexed detection, and in vivo applications in diagnostics and cellular research.
https://pubs.acs.org/doi/full/10.1021/acs.nanolett.5c00078
about 1 year ago
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reposted by
Stephanie Kath-Schorr
Stephan Hacker
about 1 year ago
The last day of
#EFMCISCB25
by
@euromedchem.bsky.social
is off to a great start with an insightful keynote lecture by Cynthia Burrows. She talked about the use of nanopore sequencing to characterize chemically modified nucleotides in RNA.
#chemsky
#ChemBio
pubs.acs.org/doi/10.1021/...
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reposted by
Stephanie Kath-Schorr
Stephan Hacker
about 1 year ago
Insightful talk by Ronald Micura at
#EFMCISCB25
by
@euromedchem.bsky.social
. He talked about his group's exciting research into covalent binders to structured RNAs. They use alkyl halides and mesylates as tempered electrophiles for this application.
www.nature.com/articles/s41...
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reposted by
Stephanie Kath-Schorr
gsbardella.bsky.social
about 1 year ago
Chaired by Claudia Höbartner, the last day at
#EFMCISCB25
starts with the PL by Cynthia Burrows (
@uofupress.bsky.social
) thrilling the audience with her nanopore studies on chemically modified RNA.
@euromedchem.bsky.social
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reposted by
Stephanie Kath-Schorr
gsbardella.bsky.social
about 1 year ago
And finally the
#EFMCISCB25
is starting, opened by Uwe Grether, co-chair of the event together with Claudia Hobartner.
@euromedchem.bsky.social
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reposted by
Stephanie Kath-Schorr
TIDE (RTG 2591)
about 1 year ago
Hello Bluesky! We are the TIDE group, a research training group working on template-designed
#organicelectronics
at
#UniCologne
and
#UniBonn
, funded by
@dfgpublic.bsky.social
. Follow us for news about our
#research
, our graduation program and events! ⠀
#phd
#phdsky
#sciencesky
#chemistry
#physics
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Welcome to our Department
@chemunicologne.bsky.social
@unicologne.bsky.social
on Bluesky 🎉🎂🍾 Please follow not to miss any updates on our research, job offers and events!
over 1 year ago
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Grateful for this wonderful group of lab members! Happy holidays and Merry Christmas!🧬🎉❄️☃️🎄
over 1 year ago
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JOB ALERT! 2 open PHD positions
@kathlab.bsky.social
in the framework of the MSCA doctoral network MeChaNiSM! Searching for organic chemists dedicated to nucleic acid chemistry.🧬⚗️🎉 More info: www.kathlab.uni-koeln.de
#organicchemistry
#nucleicacids
over 1 year ago
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Back from an exciting visit to Chalmers University Gothenburg discussing projects with Marcus Wilhelmsson and Fredrik Westerlund. Stay tuned for our PhD position offers in the MSCA doctoral network MeChaNiSM! 🎉🧬
chalmers.se/en/projects/me…
#nucleicacids
d
#chemicalbiology
gy
over 1 year ago
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reposted by
Stephanie Kath-Schorr
Thorn-Seshold Lab
over 1 year ago
📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem
#FluorescenceFriday
#chemsky
#chemtwitter
#AgentOrange
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