I reviewed On the Future of Species by Adrian Woolfson for @thelancet.com. Adrian has now responded to my review here. www.thelancet.com/journals/lan...

Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com

Guideline communication raises concerns on Lancet obesity report

New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...

no quarter can or should be given to hold this evil to account

I feel like reading the news should now come with a trigger warning. The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization. And these are only the cases we know about…

Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...

The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...

This is the essence of being an American. That is why we can not give up the fight to preserve and protect American values.

The $100 whole human genome sequence finally reached! www.sandiegouniontribune.com/2026/02/19/s...

My quote of the day A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us. John Steinbeck

Neal Katyal: "In America, the chief justice said only Congress can impose taxes on the American people, and that's what tariffs are. Tariffs are taxes."

well said - indeed a peer review system in crisis hard to find someone to review burden of review duplication and waste misuse/corruption of peer review www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News #NephSky

this isn't my faith tradition, but the idea that you are duty-bound to help others resonates with me it's a sin to walk past, never mind to exploit the victim further

Rather focus on expanding subcutaneous tissue as well.

Almost done with my next lecture, so going back now to work on some new memes

❤️‍🩹 CHI Superhero Mohammedzayn on Hyperinsulinism: “My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”

My quote of the day My dream is of a place and a time where America will once again be seen as the last best hope of earth. Abraham Lincoln

Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...

Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro ⁦‪‬⁩ ⁦‪‬⁩ www.wsj.com/health/pharm...

My quote of the day If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith. Ehsan Sehgal

One of my fav tik tok accounts was chandler and his grandma.

📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to: ✅ Better support and understanding for individuals with HI ✅ Early Diagnosis and Prompt Intervention ✅New families are reached ✅New connections are made https://linktr.ee/chcharityuk

Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs. 🧵

There is LOT more where that came from. If you like THEY KNEW, please spread the word about the $2.99 sale! I don't make hardly any money off this. I only want people to read the book and know the truth about our country, our past, and our future. Thank you!

This is must-listen for all of us who are scientists - and all who question science

I once asked a scientist whom I respect enormously her advice for a successful career and life in science. Her advice: Leave every place better than you found it. It surprises me that many people would try hard to do the compete opposite … and we would elect them to run the country.

Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.

Ah yes, the government asking Jews to register as Jewish, in the name of protecting the Jews. No way that could go wrong www.nytimes.com/2025/04/23/n...

Here’s the interview

www.nytimes.com/2025/04/21/n... “Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.” No sense of decency.

Yet here we are…

How might polygenic risk scores enhance the management of type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...

I think there is going to be a Red Rural Recession and soon if all the cuts continue as is All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states. Their finances will be turned upside

No books. No teachers. Just a centralized AI that serves as intercessor between each child and the world's knowledge. It's literally a pre-reformation view, with Grok in the place of Yahweh.

Can we all just tell big tech no already? www.pcworld.com/article/2644... #privacy #security

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

The U.S. knew COVID was airborne by Jan 2020. Taiwan flagged it Dec 31, 2019. The President admitted it “goes through the air” in Feb, and likely briefed in early Jan. Cloth masks and 6-ft rules were never going to work—and they knew it. But this elite Prof thinks she convinced Dr. Fauci?👇 😦

I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan erictopol.substack.com/p/the-busine... Open-access, in the new edition of Ground Truths

Great plain English essay open-access @science.org by @melaniemitchell.bsky.social on large reasoning models www.science.org/doi/10.1126/...

Strong column from @nytimes.com editorial board. “The people who are attacking higher education are talking nonstop,” said Holden Thorp. “And the people leading higher education are not saying very much.” www.nytimes.com/2025/03/15/o...

Hot off the press: my review of Csaba Szabo's book Unreliable; deevybee.blogspot.com/2025/03/book...

it’s the cruelest form of irony

During rounds at the NIH Clinical Center: Why can't we use GLP-1 receptor agonists (GLP-1RAs) in patients with lipodystrophy? Here’s the answer to that question.

Fathers

Counterproductive

Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion academic.oup.com/jes/article/...

In the GRADE study, liraglutide led to the greatest increases in ISR, glucose sensitivity and potentiation, remaining above baseline at study end. However, with all therapies, β-cell function progressively declined after initial improvement #diabetes diabetesjournals.org/care/article...

Functional #insulin secretory defects occur in the remaining mass of beta cells during human #T1D pathogenesis not strictly correlated with the extent of insulitis #islets www.biorxiv.org/content/10.1...