Well done @cpkotanidis.bsky.social ! Also check out our manuscript in @annalsofim.bsky.social url.us.m.mimecastprotect.com/s/kNYpCDkAO2...

2.2.1 In an RCT comparing 'uselessly elongated' vs shorter #PeerReview of @neuripsconf.bsky.social 2022 submissions, the longer reviews received higher quality scores, suggesting a length bias among reviewers, w implications for #LLM-generated reviews journals.plos.org/pl...#PeerReview#LLM-generatedscsatcmu.bsky.social

In the med literature, statements like “to our knowledge [TOK], this is the FIRST...” often replace a proper systematic search. Among 4488 PMC articles in 6 leading medical journals published 2020-2024, TOK prevalence was 21.7%, w @PLOSMedicine highest (48.4%) and @NEJM lowest (1.3%) #CornellVet

The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.org

Irish whale watching business closes after 25 years. 🐳 “There are only a few whales left - the water is overfished.” The owner was previously a commercial fisher but gave up when fish stocks crashed. “It wasn’t something I wanted to be a part of.” 🎣❌ www.irishtimes.com/ireland/2025...

🐈🐕📈📉👩‍💻🛋️

In the BATURA trial, as-needed albuterol–budesonide resulted in a lower risk of severe asthma exacerbation than as-needed albuterol among participants with disease that was uncontrolled despite treatment for mild asthma. Full trial results: nej.md/43uVpwK #ATS2025 @atscommunity.bsky.social

BRIDGE-TNK trial: Among 550 patients with stroke due to large-vessel occlusion who had presented within 4.5 hours after onset, 90-day functional outcomes were better with intravenous tenecteplase before thrombectomy than with thrombectomy alone. nej.md/3GTVKAk #ESOC2025 @esostroke.bsky.social

Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏

For a woman with device-detected atrial fibrillation, would you initiate anticoagulant therapy or recommend continuation of antiplatelet therapy? Read the case vignette and essays on both treatment options and cast your vote: nej.md/4lQzxTA #MedSky #CardioSky #Afib

Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu #MedSky #Hematology

Our partnership with @glaucomflecken.bsky.social continues as he summarizes new research into fracture prevention with infrequent zoledronate in women 50 to 60 years of age. Access the article for free: nej.md/DrG15 #MedSky

A 56-year-old man was transferred to a burn center for management of pavement burns on his feet that had occurred during a heat wave. Read the full case details: nej.md/3Rh2XfR @uwsph.bsky.social #MedSky #ClimateChange

New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT #AI #CardioOncology #CardioEd #EHJ @escardio.bsky.social

1/ 🚨 NEW #BeyondJournalClub w/ @NEJMGroup: PURPOSE Trials Both PURPOSE 1 & 2 used a new long acting medication: Lenacapavir! Let’s learn what we can takeaway from these trials ⤵️ 🖥️: coreimpodcast.com/2025/04/16/a-r…

An outstanding episode - learned a ton 🥂

Editorial: Cancer-Associated Venous Thromboembolism — Beyond 6 Months nej.md/4iB6wcA

Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrials

What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy #MedSky

The SCALE Kids trial, summarized here by NEJM Editorial Fellow Harleen Marwah, MD, assessed the efficacy and safety of liraglutide, as compared with placebo, as an adjunct treatment to lifestyle interventions, for the treatment of obesity in children 6 to 12 years of age. Full trial: nej.md/3MBP1uc

A great listen from the coreIM team on potential health effects of microplastics and a nuanced discussion on causality and limitations of observational studies ❤️👏🐥

A truly beautiful piece by Dr Lisa McNamee (@lisadangermcnamee.bsky.social)! Everyone should read this!

"By staying true to its mission and embracing necessary reforms, PEPFAR can...continue to be a beacon of hope in the fight against HIV/AIDS." Comment—PEPFAR under review: what's at stake for PEPFAR's future tinyurl.com/28ahdmv8 #MedSky

How much training do you need to do to run a 5K? 🏃 The NEJM Evidence team aims to find out in this Stats, STAT! animated video on linear regression. Watch the full video: youtu.be/qUfVrYKetfA  #MedSky #ScienceSky #Statistics

"Without research to point toward a healthier country, there will be poorer national health and less capacity to do what people do...on either end of the political spectrum." Read the Editorial by JAMA Health Forum EIC Sandro Galea and JAMA EIC @kbibbinsdomingo.bsky.social. ja.ma/4b6Z2LJ #MedSky

Perspective by Eleanor R. Menzin, MD: With U.S. politics threatening to erase the gains of science, reduce access to vaccines, and undermine their vast public health benefit, what is a conscientious pediatrician to do? Read the full Perspective: nej.md/4iZNHQW

A 29yo man with well-controlled HIV infection presented with a 1-week history of a painful, whitish discoloration on his tongue. Smooth, pink, guttate macules were present on the tongue within a white coating. Full case from @aidshealthcare.bsky.social : nej.md/4jNuAdw #MedSky #IDSky

“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av

Editorial: Medium- and Distal-Vessel Occlusion — The Limit of Thrombectomy? nej.md/40Hu9bP

In the DISTAL trial involving 543 patients with stroke due to occlusion of medium or distal vessels, endovascular treatment within 24 hours after the onset of symptoms was not effective in improving functional outcome at 90 days. nej.md/4jYWV0z #ISC25 | @ahascience.bsky.social

In the ESCAPE-MeVO trial involving patients with ischemic stroke due to medium-vessel occlusion, thrombectomy within 12 hours did not lead to a better functional outcome and lower mortality at 90 days than usual care. Full trial results: nej.md/40LTUaL #ISC25 | @ahascience.bsky.social

Epilepsy: ‘It’s like having the sword of Damocles above your head’

An 84-year-old man with benign prostatic hyperplasia who had been admitted to the hospital with acute kidney injury due to obstructive uropathy was noted to have gray skin. The skin changes had been present for 5 years. 1/3 #MedSky

From March through October 2024, a total of 46 human cases of highly pathogenic avian influenza A(H5N1) virus infections were identified in the United States, with 20 linked to poultry exposure and 25 to dairy cow exposure. Read the full article: nej.md/3VU4R8I  #MedSky #IDSky

1/ 🚨 NEW #BeyondJournalClub with @NEJMGroup: REVISE Trial Do PPIs reduce the risk of clinically important upper GI bleeding? ⤵️ 🖥️: coreimpodcast.com/2024/12/11/str… Sponsor: Freed AI

@nejm.org is seeking submissions for images highlighting the health impact of climate change to be featured during Earth Month 2025. Info at nejm.org/event-info #MedSky #ClimateChange #EnvironmentalHealth

This is a reminder that spurious correlations can be observed in observational studies. We should be skeptical of this type of data. Hypothesis generating. Proper RCTs should be performed if possible to conclude causation. www.tylervigen.com/spurious-cor... #MedSky

Irish people will die in significant numbers due to rising temperatures. Irish people will die in significant numbers due to rising temperatures, HSE specialist claims, yet #ClimateChange remains a peripheral issue of the #GE24.

The New England Journal of Medicine is inviting submissions for Images in Clinical Medicine on the theme of health impacts of climate. Deadline is 1 Jan! See nejm.org for details #climate #healthimpactofclimatechange #climateandhealth #climatecrisis